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  3. NTHL1

NTHL1 (Nth like DNA glycosylase 1)

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The Function of NTHL1

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

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Protein names

Recommended name:

Endonuclease III-like protein 1

Alternative name(s):

hNTH1
Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site
DNA glycosylase/AP lyase

NTHL1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2516739 (NTHL1) ??

Top Gene-Substance Interactions

Substances That Increase NTHL1

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Substances That Decrease NTHL1

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Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • Brachyury

Tissue specificity:

Widely expressed with highest levels in heart and lowest levels in lung and liver.

Gene Pathways:

  • Base excision repair
  • DNA Repair

Developmental stage:

Expression levels are regulated during the cell cycle with increased levels during early and mid S-phase.

Enzyme Regulation:

APE1 displaces NTHL1 from the N-glycosylase-generated AP site in DNA, thereby increasing the turnover of the DNA N-glycosylase activity. AP lyase activity is stimulated by YBX1.

Cofactor:

Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.

Molecular Function:

  • 4 Iron, 4 Sulfur Cluster Binding
  • Dna-(Apurinic Or Apyrimidinic Site) Lyase Activity
  • Dna N-Glycosylase Activity
  • Double-Stranded Dna Binding
  • Endonuclease Activity
  • Metal Ion Binding
  • Oxidized Purine Nucleobase Lesion Dna N-Glycosylase Activity
  • Oxidized Pyrimidine Nucleobase Lesion Dna N-Glycosylase Activity

Biological Processes:

  • Base-Excision Repair, Ap Site Formation
  • Depyrimidination
  • Nucleotide-Excision Repair, Dna Incision, 5'-To Lesion
  • Mitophagy In Response To Mitochondrial Depolarization
  • Positive Regulation Of Defense Response To Virus By Host
  • Xenophagy
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_08750| Anapl_17170| AS27_12355| AS28_11206| bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase| CB1_000144039| CHNTHL1| DNA glycoslyase/AP lyase| Endonuclease III-like 1| Endonuclease III-like protein 1| Escherichia coli endonuclease III-like 1| FAP3| H920_03744| hNTH1| M91_18822| M959_10070| MDA_GLEAN10007749| N300_14197| N301_13379| N302_11751| N303_05092| N305_14941| N306_14296| N307_07639| N308_15683| N309_05538| N310_04728| N311_07729| N312_02581| N320_05474| N321_07889| N322_06181| N326_01847| N327_10044| N328_05670| N329_05791| N330_06734| N332_09963| N333_02475| N334_09974| N335_08480| N339_05069| N340_09020| Nth1| nth endonuclease III-like 1| nth (endonuclease III)-like 1 (E.coli)| nth endonuclease III-like 1 (E. coli)| nth-like DNA glycosylase 1| Octs3| PANDA_016228| putative Endonuclease III-like protein 1| RUN domain containing 3A| thymine glycol DNA glycosylase/AP lyase| TREES_T100011739| UY3_05890| Y1Q_012731| Y956_00682| Z169_10389| nthl1

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