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NT5E (5'-nucleotidase ecto)

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The Function of NT5E

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.

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Protein names

Recommended name:

5'-nucleotidase

Short name:

5'-NT

Alternative name(s):

Ecto-5'-nucleotidase
CD antigen CD73

NT5E SNPs

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  1. RS494562 (NT5E) ??

Top Gene-Substance Interactions

NT5E Interacts with These Diseases

Disease Score

Substances That Increase NT5E

Substances Interaction Organism Category

Substances That Decrease NT5E

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • AhR
  • c-Jun
  • AP-1
  • RORalpha2
  • GR

Gene Pathways:

  • Nicotinate and nicotinamide metabolism
  • Purine metabolism
  • Pyrimidine metabolism
  • Metabolism
  • Metabolic pathways

Molecular Function:

  • Nucleotide Binding
  • Ferrous Iron Binding
  • 5'-Nucleotidase Activity
  • Metal Ion Binding

Biological Processes:

  • Purine Nucleotide Biosynthetic Process
  • Purine Nucleotide Catabolic Process
  • Amp Catabolic Process
  • Dna Metabolic Process
  • Leukocyte Cell-Cell Adhesion
  • Brain Development
  • Response To Aluminum Ion
  • Adenosine Biosynthetic Process
  • Pyrimidine Nucleoside Catabolic Process
  • Positive Regulation Of Lipid Biosynthetic Process
  • Negative Regulation Of Inflammatory Response

Drug Bank:

  • Cytarabine
  • Pentoxifylline
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5'-NT| 5-nucleotidase| 5'-nucleotidase| 5 nucleotidase, ecto| 5' nucleotidase, ecto| 5'-nucleotidase, ecto (CD73)| 5'-nucleotidase isoform 1 preproprotein| A306_10270| AS27_06435| AS28_12073| CALJA| CB1_000371029| CD73| D623_10004633| E5NT| Ecto-5'-nucleotidase| EGK_15133| eN| eNT| GW7_13474| H920_12624| I79_000898| M91_20600| M959_03868| N300_01133| N301_04203| N302_15563| N303_02345| N305_14252| N306_02186| N307_14474| N308_11580| N309_10056| N310_13300| N311_02562| N312_13701| N320_11058| N321_05340| N322_04482| N326_01865| N327_11655| N331_04801| N332_13759| N333_03044| N335_00897| N336_07216| N339_09491| N340_02820| N341_09820| NT| Nt5| NTE| PAL_GLEAN10025199| PANDA_012315| Purine 5-Prime-Nucleotidase| TREES_T100001478| Y1Q_010844| Y956_07863| Z169_10493| nt5e

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