The Function of NT5C1A
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
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Protein names
Recommended name:
Cytosolic 5'-nucleotidase 1AAlternative name(s):
cN1ACytosolic 5'-nucleotidase IA
cN-I
cN-IA
- RS873917 (NT5C1A) ??
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Top Gene-Substance Interactions
Substances That Increase NT5C1A
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Substances That Decrease NT5C1A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
Enzyme Regulation:
Activated by ADP.
Molecular Function:
Biological Processes:
- Adenosine Metabolic Process
- Nucleoside Metabolic Process
- Purine Nucleoside Monophosphate Catabolic Process
- Purine Nucleotide Catabolic Process
- Pyrimidine Nucleoside Catabolic Process