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  3. NRP2

NRP2 (Neuropilin 2)

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The Function of NRP2

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

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Protein names

Recommended name:

Neuropilin-2

Alternative name(s):

Vascular endothelial cell growth factor 165 receptor 2

Top Gene-Substance Interactions

NRP2 Interacts with These Diseases

Disease Score

Substances That Increase NRP2

Substances Interaction Organism Category

Substances That Decrease NRP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • MEF-2A
  • c-Myc
  • Meis-1
  • Brachyury
  • Meis-1b

Gene Pathways:

  • Signal Transduction

Molecular Function:

  • Calcium Ion Binding
  • Cytokine Binding
  • Growth Factor Binding
  • Heparin Binding
  • Metal Ion Binding
  • Receptor Activity
  • Semaphorin Receptor Activity
  • Vascular Endothelial Growth Factor-Activated Receptor Activity

Biological Processes:

  • Neuron Cellular Homeostasis
  • Angiogenesis
  • Axon Extension Involved In Axon Guidance
  • Axon Guidance
  • Cell Adhesion
  • Nerve Development
  • Positive Regulation Of Endothelial Cell Migration
  • Positive Regulation Of Endothelial Cell Proliferation
  • Semaphorin-Plexin Signaling Pathway Involved In Neuron Projection Guidance
  • Sympathetic Ganglion Development
  • Sympathetic Neuron Projection Extension
  • Sympathetic Neuron Projection Guidance
  • Vascular Endothelial Growth Factor Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_01990| AS27_04033| AS28_03278| CB1_002756009| D623_10028393| GW7_16216| H920_20283| M959_04814| MDA_GLEAN10017313| N301_02496| N302_06681| N305_06699| N311_08198| N312_04651| N320_06159| N324_02622| N328_12782| N330_02828| N332_09679| N334_04800| N340_06045| Neuropilin-2| neuropilin-2a(17)| neuropilin-2a(22)| neuropilin-2b(0)| neuropilin-2-like protein| Np2| Np-2| Npn-2| NPN2| PAL_GLEAN10026144| PANDA_009285| pro2714| receptor for VEGF165 and semaphorins class3| TREES_T100000259| UY3_18554| vascular endothelial cell growth factor 165 receptor 2| VEGF165R2| Y1Q_029983| Y956_07557| nrp2

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