The Function of NRP2
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
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Protein names
Recommended name:
Neuropilin-2Alternative name(s):
Vascular endothelial cell growth factor 165 receptor 2Top Gene-Substance Interactions
NRP2 Interacts with These Diseases
| Disease | Score |
Substances That Increase NRP2
| Substances | Interaction | Organism | Category |
Substances That Decrease NRP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Receptor Activity
- Vascular Endothelial Growth Factor-Activated Receptor Activity
- Calcium Ion Binding
- Heparin Binding
- Semaphorin Receptor Activity
- Growth Factor Binding
- Cytokine Binding
- Metal Ion Binding
Biological Processes:
- Angiogenesis
- Positive Regulation Of Endothelial Cell Proliferation
- Cell Adhesion
- Axon Guidance
- Positive Regulation Of Endothelial Cell Migration
- Nerve Development
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Axon Extension Involved In Axon Guidance
- Sympathetic Ganglion Development
- Neuron Cellular Homeostasis
- Sympathetic Neuron Projection Extension
- Sympathetic Neuron Projection Guidance
- Semaphorin-Plexin Signaling Pathway Involved In Neuron Projection Guidance