Summary of NRP1
The gene codes for a protein, neuropilin 1. It helps control cell migration [R].
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The Function of NRP1
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Protein names
Recommended name:
Neuropilin-1Alternative name(s):
Vascular endothelial cell growth factor 165 receptorCD antigen CD304
- RS2228638 (NRP1) ??
- RS2506155 (NRP1) ??
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Top Gene-Substance Interactions
NRP1 Interacts with These Diseases
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Substances That Increase NRP1
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Substances That Decrease NRP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Gene Pathways:
Molecular Function:
- Coreceptor Activity
- Cytokine Binding
- Growth Factor Binding
- Heparin Binding
- Metal Ion Binding
- Semaphorin Receptor Activity
- Vascular Endothelial Growth Factor-Activated Receptor Activity
- Vascular Endothelial Growth Factor Binding
Biological Processes:
- Angiogenesis
- Angiogenesis Involved In Coronary Vascular Morphogenesis
- Animal Organ Morphogenesis
- Artery Morphogenesis
- Axonal Fasciculation
- Axon Extension Involved In Axon Guidance
- Axon Guidance
- Axonogenesis Involved In Innervation
- Branchiomotor Neuron Axon Guidance
- Cell-Cell Signaling
- Cell Migration Involved In Sprouting Angiogenesis
- Cellular Response To Hepatocyte Growth Factor Stimulus
- Cellular Response To Vascular Endothelial Growth Factor Stimulus
- Commissural Neuron Axon Guidance
- Coronary Artery Morphogenesis
- Dendrite Development
- Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
- Dorsal Root Ganglion Morphogenesis
- Endothelial Cell Chemotaxis
- Endothelial Tip Cell Fate Specification
- Facial Nerve Structural Organization
- Facioacoustic Ganglion Development
- Gonadotrophin-Releasing Hormone Neuronal Migration To The Hypothalamus
- Hepatocyte Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Axon Extension Involved In Axon Guidance
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Neuron Apoptotic Process
- Nerve Development
- Neural Crest Cell Migration Involved In Autonomic Nervous System Development
- Neuron Migration
- Otic Placode Development
- Branching Involved In Blood Vessel Morphogenesis
- Platelet-Derived Growth Factor Receptor Signaling Pathway
- Positive Chemotaxis
- Positive Regulation Of Axon Extension Involved In Axon Guidance
- Positive Regulation Of Cytokine Activity
- Positive Regulation Of Endothelial Cell Migration
- Positive Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Retinal Ganglion Cell Axon Guidance
- Positive Regulation Of Smooth Muscle Cell Migration
- Protein Localization To Early Endosome
- Regulation Of Retinal Ganglion Cell Axon Guidance
- Regulation Of Vesicle-Mediated Transport
- Renal Artery Morphogenesis
- Response To Wounding
- Retinal Ganglion Cell Axon Guidance
- Retina Vasculature Morphogenesis In Camera-Type Eye
- Semaphorin-Plexin Signaling Pathway
- Semaphorin-Plexin Signaling Pathway Involved In Axon Guidance
- Semaphorin-Plexin Signaling Pathway Involved In Neuron Projection Guidance
- Sensory Neuron Axon Guidance
- Signal Transduction
- Sprouting Angiogenesis
- Sympathetic Ganglion Development
- Sympathetic Neuron Projection Extension
- Sympathetic Neuron Projection Guidance
- Toxin Transport
- Trigeminal Ganglion Development
- Trigeminal Nerve Structural Organization
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Vegf-Activated Neuropilin Signaling Pathway
- Vegf-Activated Neuropilin Signaling Pathway Involved In Axon Guidance
- Ventral Trunk Neural Crest Cell Migration
- Vestibulocochlear Nerve Structural Organization
- Otic Placode Formation
Drug Bank:
- Palifermin
- Pegaptanib