Summary of NRP1
The gene codes for a protein, neuropilin 1. It helps control cell migration [R].
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The Function of NRP1
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Protein names
Recommended name:
Neuropilin-1Alternative name(s):
Vascular endothelial cell growth factor 165 receptorCD antigen CD304
- RS2228638 (NRP1) ??
- RS2506155 (NRP1) ??
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Top Gene-Substance Interactions
NRP1 Interacts with These Diseases
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Substances That Increase NRP1
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Substances That Decrease NRP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Gene Pathways:
Molecular Function:
- Vascular Endothelial Growth Factor-Activated Receptor Activity
- Heparin Binding
- Coreceptor Activity
- Semaphorin Receptor Activity
- Growth Factor Binding
- Cytokine Binding
- Vascular Endothelial Growth Factor Binding
- Metal Ion Binding
Biological Processes:
- Angiogenesis
- Branching Involved In Blood Vessel Morphogenesis
- Neuron Migration
- Positive Regulation Of Endothelial Cell Proliferation
- Sprouting Angiogenesis
- Cell Migration Involved In Sprouting Angiogenesis
- Signal Transduction
- Cell-Cell Signaling
- Axon Guidance
- Axonal Fasciculation
- Response To Wounding
- Animal Organ Morphogenesis
- Positive Regulation Of Endothelial Cell Migration
- Positive Regulation Of Smooth Muscle Cell Migration
- Dendrite Development
- Facial Nerve Structural Organization
- Trigeminal Nerve Structural Organization
- Vestibulocochlear Nerve Structural Organization
- Nerve Development
- Branchiomotor Neuron Axon Guidance
- Gonadotrophin-Releasing Hormone Neuronal Migration To The Hypothalamus
- Retinal Ganglion Cell Axon Guidance
- Cellular Response To Hepatocyte Growth Factor Stimulus
- Endothelial Cell Chemotaxis
- Cellular Response To Vascular Endothelial Growth Factor Stimulus
- Ventral Trunk Neural Crest Cell Migration
- Vegf-Activated Neuropilin Signaling Pathway
- Otic Placode Formation
- Negative Regulation Of Neuron Apoptotic Process
- Platelet-Derived Growth Factor Receptor Signaling Pathway
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Hepatocyte Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Axon Extension Involved In Axon Guidance
- Negative Regulation Of Axon Extension Involved In Axon Guidance
- Artery Morphogenesis
- Axon Extension Involved In Axon Guidance
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Chemotaxis
- Positive Regulation Of Cytokine Activity
- Axonogenesis Involved In Innervation
- Regulation Of Vesicle-Mediated Transport
- Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
- Angiogenesis Involved In Coronary Vascular Morphogenesis
- Coronary Artery Morphogenesis
- Retina Vasculature Morphogenesis In Camera-Type Eye
- Renal Artery Morphogenesis
- Sympathetic Ganglion Development
- Trigeminal Ganglion Development
- Positive Regulation Of Erk1 And Erk2 Cascade
- Semaphorin-Plexin Signaling Pathway
- Commissural Neuron Axon Guidance
- Regulation Of Retinal Ganglion Cell Axon Guidance
- Endothelial Tip Cell Fate Specification
- Sensory Neuron Axon Guidance
- Sympathetic Neuron Projection Extension
- Sympathetic Neuron Projection Guidance
- Neural Crest Cell Migration Involved In Autonomic Nervous System Development
- Toxin Transport
- Semaphorin-Plexin Signaling Pathway Involved In Neuron Projection Guidance
- Semaphorin-Plexin Signaling Pathway Involved In Axon Guidance
- Positive Regulation Of Retinal Ganglion Cell Axon Guidance
- Vegf-Activated Neuropilin Signaling Pathway Involved In Axon Guidance
- Protein Localization To Early Endosome
- Facioacoustic Ganglion Development
- Dorsal Root Ganglion Morphogenesis
- Otic Placode Development
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Drug Bank:
- Palifermin
- Pegaptanib