Summary of NRIP1
The Function of NRIP1
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.
Protein names
Recommended name:
Nuclear receptor-interacting protein 1Alternative name(s):
Nuclear factor RIP140Receptor-interacting protein 140
- RS2229741 (NRIP1) ??
- RS2823048 (NRIP1) ??
- RS2823053 (NRIP1) ??
- RS2823093 (NRIP1) ??
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Top Gene-Substance Interactions
NRIP1 Interacts with These Diseases
| Disease | Score |
Substances That Increase NRIP1
| Substances | Interaction | Organism | Category |
Substances That Decrease NRIP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Induction:
Expressed in a circadian manner in the liver (at protein level).
Molecular Function:
- Core Promoter Sequence-Specific Dna Binding
- Transcription Coactivator Activity
- Transcription Corepressor Activity
- Estrogen Receptor Binding
- Nuclear Hormone Receptor Binding
- Glucocorticoid Receptor Binding
- Androgen Receptor Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Ovarian Follicle Rupture
- Transcription, Dna-Templated
- Circadian Rhythm
- Lipid Storage
- Androgen Receptor Signaling Pathway
- Circadian Regulation Of Gene Expression
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cellular Response To Estradiol Stimulus