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  3. NRIP1

NRIP1 (Nuclear receptor interacting protein 1)

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Summary of NRIP1

The gene codes for a protein, nuclear receptor interacting protein 1. It modulates transcriptional activity of the estrogen receptor [R].

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The Function of NRIP1

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.

Protein names

Recommended name:

Nuclear receptor-interacting protein 1

Alternative name(s):

Nuclear factor RIP140
Receptor-interacting protein 140

NRIP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2229741 (NRIP1) ??
  2. RS2823048 (NRIP1) ??
  3. RS2823053 (NRIP1) ??
  4. RS2823093 (NRIP1) ??

Top Gene-Substance Interactions

NRIP1 Interacts with These Diseases

Disease Score

Substances That Increase NRIP1

Substances Interaction Organism Category

Substances That Decrease NRIP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • Sp1
  • c-Fos

Induction:

Expressed in a circadian manner in the liver (at protein level).

Molecular Function:

  • Androgen Receptor Binding
  • Core Promoter Sequence-Specific Dna Binding
  • Estrogen Receptor Binding
  • Glucocorticoid Receptor Binding
  • Nuclear Hormone Receptor Binding
  • Transcription Coactivator Activity
  • Transcription Corepressor Activity

Biological Processes:

  • Androgen Receptor Signaling Pathway
  • Cellular Response To Estradiol Stimulus
  • Circadian Regulation Of Gene Expression
  • Circadian Rhythm
  • Lipid Storage
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Ovarian Follicle Rupture
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 9630050P12| Anapl_16065| AS27_05171| AS28_02463| CB1_000706029| GW7_20202| H920_14435| M959_14212| N300_14753| N301_10240| N306_07701| N307_10957| N308_06276| N309_05524| N310_00156| N311_01588| N312_06445| N320_11441| N321_08288| N322_01783| N324_04121| N326_10336| N327_13490| N328_01703| N329_08832| N330_14434| N331_04500| N332_07600| N333_12185| N334_06313| N336_01229| N339_11311| N341_09860| nuclear factor RIP140| Nuclear receptor-interacting protein 1| PAL_GLEAN10016364| PANDA_002382| receptor-interacting protein 140| RIP140| TREES_T100010866| UY3_09839| Y1Q_013137| Y956_06832| Z169_10875| nrip1

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