The Function of NRG4
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
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Protein names
Recommended name:
Pro-neuregulin-4, membrane-bound isoformShort name:
NRG-4Alternative name(s):
Pro-NRG4- RS11072566 (NRG4) ??
- RS4886755 (NRG4) ??
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Top Gene-Substance Interactions
Substances That Increase NRG4
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Substances That Decrease NRG4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Receptor Binding
Biological Processes:
- Animal Organ Development
- Erbb2 Signaling Pathway
- Intracellular Signal Transduction
- Mapk Cascade
- Phosphatidylinositol-Mediated Signaling
- Regulation Of Cell Motility
- Regulation Of Phosphatidylinositol 3-Kinase Signaling