Summary of NRAS
The gene codes for a protein, neuroblastoma RAS viral oncogene homolog. Mutations are linked to somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia [R].
The Function of NRAS
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Protein names
Recommended name:
GTPase NRasAlternative name(s):
Transforming protein N-Ras- RS10489525 (NRAS) ??
- RS11554290 (NRAS) ??
- RS8453 (NRAS) ??
- RS926938 (NRAS) ??
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Top Gene-Substance Interactions
NRAS Interacts with These Diseases
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Substances That Increase NRAS
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Substances That Decrease NRAS
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Advanced Summary
autoimmune lymphoproliferative syndrome Genetics Home Reference provides information about autoimmune lymphoproliferative syndrome. core binding factor acute myeloid leukemia Genetics Home Reference provides information about core binding factor acute myeloid leukemia. cytogenetically normal acute myeloid leukemia Genetics Home Reference provides information about cytogenetically normal acute myeloid leukemia. epidermal nevus Genetics Home Reference provides information about epidermal nevus. giant congenital melanocytic nevus At least two mutations in the NRAS gene have been found to cause giant congenital melanocytic nevus. This condition is characterized by a large, noncancerous patch of abnormally dark skin that is present from birth and an increased risk of a type of skin cell cancer called melanoma. The NRAS gene mutations that cause this condition are somatic, meaning that they occur during a person's lifetime and are present only in certain cells. The mutations occur during embryonic development in cells that will develop into pigment-producing skin cells (melanocytes). The mutations that cause this condition affect a single protein building block (amino acid) in the N-Ras protein. Specifically, the mutations replace the amino acid glutamine at position 61 with either lysine or arginine (written as Gln61Lys or Q61K and Gln61Arg or Q61R). These mutations lead to production of an N-Ras protein that is constantly turned on (constitutively active). Instead of triggering cell growth in response to particular signals from outside the cell, the overactive protein directs cells to grow and divide constantly. The uncontrolled cell growth of early melanocytes leads to a large patch of darkly pigmented skin characteristic of giant congenital melanocytic nevus. Uncontrolled cell growth of melanocytes after birth contributes to the risk of developing melanoma in people with giant congenital melanocytic nevus. lung cancer Genetics Home Reference provides information about lung cancer. Noonan syndrome Genetics Home Reference provides information about Noonan syndrome. cancers Somatic mutations in the NRAS gene are involved in the development of several types of cancer. These mutations lead to an N-Ras protein that is constitutively active and can direct cells to grow and divide without control. Studies suggest that NRAS gene mutations are common in the aggressive skin cancer melanoma, including individuals without giant congenital melanocytic nevus (described above). Mutations in the NRAS gene have also been found in other types of cancer. For reasons that are unclear, inherited mutations in the NRAS gene do not appear to increase the risk of cancer in people with Noonan syndrome.
The NRAS gene provides instructions for making a protein called N-Ras that is involved primarily in regulating cell division. Through a process known as signal transduction, the protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate). The N-Ras protein is a GTPase, which means it converts a molecule called GTP into another molecule called GDP. The N-Ras protein acts like a switch, and it is turned on and off by the GTP and GDP molecules. To transmit signals, the N-Ras protein must be turned on by attaching (binding) to a molecule of GTP. The N-Ras protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not relay signals to the cell's nucleus. The NRAS gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous. The NRAS gene is in the Ras family of oncogenes, which also includes two other genes: HRAS and KRAS. The proteins produced from these three genes are GTPases. These proteins play important roles in cell division, cell differentiation, and the self-destruction of cells (apoptosis).
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Immune System
- Non-small cell lung cancer
- Hemostasis
- Melanogenesis
- Insulin signaling pathway
- Pathways in cancer
- T cell receptor signaling pathway
- Disease
- Neurotrophin signaling pathway
- Chemokine signaling pathway
- Axon guidance
- Bladder cancer
- Long-term potentiation
- VEGF signaling pathway
- Melanoma
- Fc epsilon RI signaling pathway
- Prostate cancer
- Endometrial cancer
- Thyroid cancer
- Glioma
- Long-term depression
- MAPK signaling pathway
- Signal Transduction
- Tight junction
- B cell receptor signaling pathway
- Acute myeloid leukemia
- Chronic myeloid leukemia
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Natural killer cell mediated cytotoxicity
- Hepatitis C
- GnRH signaling pathway
Enzyme Regulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
Molecular Function:
Biological Processes:
- Axon Guidance
- Epidermal Growth Factor Receptor Signaling Pathway
- Erbb2 Signaling Pathway
- Establishment Of Protein Localization To Golgi
- Fc-Epsilon Receptor Signaling Pathway
- Leukocyte Migration
- Mapk Cascade
- Ras Protein Signal Transduction
- Stimulatory C-Type Lectin Receptor Signaling Pathway