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  3. NR4A1

NR4A1 (Nuclear receptor subfamily 4 group A member 1)

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The Function of NR4A1

Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.

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Protein names

Recommended name:

Nuclear receptor subfamily 4 group A member 1

Alternative name(s):

Early response protein NAK1
Nuclear hormone receptor NUR/77
Nur77
Orphan nuclear receptor HMR
Orphan nuclear receptor TR3
ST-59
Testicular receptor 3

NR4A1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2603751 (NR4A1) ??
  2. RS2701124 (NR4A1) ??

Top Gene-Substance Interactions

NR4A1 Interacts with These Diseases

Disease Score

Substances That Increase NR4A1

Substances Interaction Organism Category

Substances That Decrease NR4A1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • c-Fos

Tissue specificity:

Fetal muscle and adult liver, brain and thyroid.

Gene Pathways:

  • Disease
  • Immune System
  • MAPK signaling pathway
  • Signal Transduction
  • Gene Expression

Induction:

By growth-stimulating agents.

Molecular Function:

  • Dna Binding
  • Protein Heterodimerization Activity
  • Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
  • Sequence-Specific Dna Binding
  • Steroid Hormone Receptor Activity
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Zinc Ion Binding

Biological Processes:

  • Cell Migration Involved In Sprouting Angiogenesis
  • Cellular Response To Corticotropin-Releasing Hormone Stimulus
  • Cellular Response To Fibroblast Growth Factor Stimulus
  • Cellular Response To Vascular Endothelial Growth Factor Stimulus
  • Endothelial Cell Chemotaxis
  • Fat Cell Differentiation
  • Negative Regulation Of Cell Cycle
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Type B Pancreatic Cell Proliferation
  • Signal Transduction
  • Transcription Initiation From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_13208| D623_10023068| early response protein NAK1| Gfrp| gfrp1| growth factor-inducible nuclear protein N10| Hbr1| Hbr-1| hmr| hormone receptor| immediate early gene transcription factor NGFI-B| M91_10622| MDA_GLEAN10015503| n10| nak-1| nerve growth factor IB nuclear receptor variant 1| nerve growth factor induced protein I-B| neural orphan nuclear receptor NUR77| ngf1b| ngfib| Ngfi-b| NP10| nr4a2| nuclear hormone receptor NUR/77| nuclear protein N10| nuclear receptor subfamily 4, group A, member 1| nuclear receptor subfamily 4, group A, member 2| Nur77| orphan nuclear receptor HMR| orphan nuclear receptor NGFI-B| orphan nuclear receptor NR4A1| orphan nuclear receptor TR3| PAL_GLEAN10005111| ST-59| steroid receptor TR3| testicular receptor 3| TIS1| tr3| TR3 orphan receptor| TREES_T100001251| UY3_11646| Y1Q_002467| Y956_16245| nr4a1

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