The Function of NR4A1
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.
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Protein names
Recommended name:
Nuclear receptor subfamily 4 group A member 1Alternative name(s):
Early response protein NAK1Nuclear hormone receptor NUR/77
Nur77
Orphan nuclear receptor HMR
Orphan nuclear receptor TR3
ST-59
Testicular receptor 3
- RS2603751 (NR4A1) ??
- RS2701124 (NR4A1) ??
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Top Gene-Substance Interactions
NR4A1 Interacts with These Diseases
| Disease | Score |
Substances That Increase NR4A1
| Substances | Interaction | Organism | Category |
Substances That Decrease NR4A1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Fetal muscle and adult liver, brain and thyroid.
Gene Pathways:
Induction:
By growth-stimulating agents.
Molecular Function:
- Dna Binding
- Protein Heterodimerization Activity
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Steroid Hormone Receptor Activity
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Zinc Ion Binding
Biological Processes:
- Cell Migration Involved In Sprouting Angiogenesis
- Cellular Response To Corticotropin-Releasing Hormone Stimulus
- Cellular Response To Fibroblast Growth Factor Stimulus
- Cellular Response To Vascular Endothelial Growth Factor Stimulus
- Endothelial Cell Chemotaxis
- Fat Cell Differentiation
- Negative Regulation Of Cell Cycle
- Positive Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Type B Pancreatic Cell Proliferation
- Signal Transduction
- Transcription Initiation From Rna Polymerase Ii Promoter