The Function of NR2C2
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Protein names
Recommended name:
Nuclear receptor subfamily 2 group C member 2Alternative name(s):
Orphan nuclear receptor TAK1Orphan nuclear receptor TR4
Testicular receptor 4
Top Gene-Substance Interactions
NR2C2 Interacts with These Diseases
| Disease | Score |
Substances That Increase NR2C2
| Substances | Interaction | Organism | Category |
Substances That Decrease NR2C2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Induced by oxidative stress via FOXO3 activation.
Developmental stage:
Transiently repressed during the meiotic phase of spermatogenesis.
Molecular Function:
- Protein Heterodimerization Activity
- Receptor Activity
- Sequence-Specific Dna Binding
- Steroid Hormone Receptor Activity
- Transcription Coactivator Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Zinc Ion Binding
Biological Processes:
- Cell Differentiation
- Cerebellum Development
- Meiotic Cell Cycle
- Nervous System Development
- P38mapk Cascade
- Positive Regulation Of Behavior
- Positive Regulation Of Embryonic Development
- Positive Regulation Of Myoblast Differentiation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Transcription, Dna-Templated
- Spermatogenesis
- Transcription Initiation From Rna Polymerase Ii Promoter
- Mitophagy In Response To Mitochondrial Depolarization