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  3. NR2C2

NR2C2 (Nuclear receptor subfamily 2 group C member 2)

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The Function of NR2C2

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

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Protein names

Recommended name:

Nuclear receptor subfamily 2 group C member 2

Alternative name(s):

Orphan nuclear receptor TAK1
Orphan nuclear receptor TR4
Testicular receptor 4

Top Gene-Substance Interactions

NR2C2 Interacts with These Diseases

Disease Score

Substances That Increase NR2C2

Substances Interaction Organism Category

Substances That Decrease NR2C2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • Sp1
  • p300

Gene Pathways:

  • Gene Expression

Induction:

Induced by oxidative stress via FOXO3 activation.

Developmental stage:

Transiently repressed during the meiotic phase of spermatogenesis.

Molecular Function:

  • Protein Heterodimerization Activity
  • Receptor Activity
  • Sequence-Specific Dna Binding
  • Steroid Hormone Receptor Activity
  • Transcription Coactivator Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Zinc Ion Binding

Biological Processes:

  • Cell Differentiation
  • Cerebellum Development
  • Meiotic Cell Cycle
  • Nervous System Development
  • P38mapk Cascade
  • Positive Regulation Of Behavior
  • Positive Regulation Of Embryonic Development
  • Positive Regulation Of Myoblast Differentiation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Transcription, Dna-Templated
  • Spermatogenesis
  • Transcription Initiation From Rna Polymerase Ii Promoter
  • Mitophagy In Response To Mitochondrial Depolarization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| TAK1| A306_08531| AS27_07353| AS28_07489| CB1_000465027| D623_10028273| EGK_03993| EH28_00484| gb:dq017625| H920_11144| M959_07752| MDA_GLEAN10023775| N300_04417| N301_10575| N302_16161| N303_14496| N305_14758| N306_01053| N307_02273| N308_16068| N309_07107| N310_06764| N320_07356| N321_05097| N322_01621| N324_09859| N326_04848| N327_10289| N328_08937| N330_04141| N331_02352| N332_07588| N333_05995| N334_14067| N335_12735| N336_04468| N339_10577| N340_05425| N341_05977| Nuclear hormone receptor TR4| nuclear receptor subfamily 2, group C, member 2| nuclear receptor subfamily 2, group H, member 2| orphan nuclear receptor TAK1| orphan nuclear receptor TR4| orphan receptor TR4| orphan receptor, TR4| orphan steroid hormone receptor 2| PAL_GLEAN10015892| PANDA_010183| testicular nuclear receptor 4| testicular receptor 4| tr2r1| Tr4| TR4-NS orphan receptor| TR4 orphan receptor| TREES_T100019827| UY3_07207| xDOR2| Y956_15223| Z169_08071| nr2c2

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