Summary of NR1I3
The gene codes for a protein, nuclear receptor subfamily 1 group I member 3. It regulates xenobiotic and endobiotic metabolism [R].
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The Function of NR1I3
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Protein names
Recommended name:
Nuclear receptor subfamily 1 group I member 3Short name:
CARAlternative name(s):
Constitutive activator of retinoid responseConstitutive active response
Constitutive androstane receptor
Orphan nuclear receptor MB67
- RS2307424 (NR1I3) ??
- RS2502815 (NR1I3) ??
- RS4073054 (NR1I3) ??
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Top Gene-Substance Interactions
NR1I3 Interacts with These Diseases
| Disease | Score |
Substances That Increase NR1I3
| Substances | Interaction | Organism | Category |
Substances That Decrease NR1I3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Predominantly expressed in liver.
Gene Pathways:
Induction:
By dexamethasone.
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Coactivator Activity
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- Androgen Receptor Activity
- Thyroid Hormone Receptor Activity
- Zinc Ion Binding
Biological Processes:
- Osteoblast Differentiation
- Transcription Initiation From Rna Polymerase Ii Promoter
- Signal Transduction
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter