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  3. NR1I3

NR1I3 (Nuclear receptor subfamily 1 group I member 3)

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Summary of NR1I3

The gene codes for a protein, nuclear receptor subfamily 1 group I member 3. It regulates xenobiotic and endobiotic metabolism [R].

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The Function of NR1I3

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.

Protein names

Recommended name:

Nuclear receptor subfamily 1 group I member 3

Short name:

CAR

Alternative name(s):

Constitutive activator of retinoid response
Constitutive active response
Constitutive androstane receptor
Orphan nuclear receptor MB67

NR1I3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2307424 (NR1I3) ??
  2. RS2502815 (NR1I3) ??
  3. RS4073054 (NR1I3) ??

Top Gene-Substance Interactions

NR1I3 Interacts with These Diseases

Disease Score

Substances That Increase NR1I3

Substances Interaction Organism Category

Substances That Decrease NR1I3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Predominantly expressed in liver.

Gene Pathways:

  • Gene Expression

Induction:

By dexamethasone.

Molecular Function:

  • Androgen Receptor Activity
  • Dna Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
  • Thyroid Hormone Receptor Activity
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Coactivator Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Zinc Ion Binding

Biological Processes:

  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Signal Transduction
  • Transcription Initiation From Rna Polymerase Ii Promoter
  • Osteoblast Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CAR| CAR1| CAR-beta| Care2| CB1_000141028| constitutive activator of retinoid response| constitutive active receptor| constitutive active response| constitutive androstane nuclear receptor variant 2| constitutive androstane nuclear receptor variant 3| constitutive androstane nuclear receptor variant 4| constitutive androstane nuclear receptor variant 5| constitutive androstane receptor| constitutive androstane receptor NR1I3| constitutive androstane receptor protein variant 1| constitutive androstane receptor protein variant 2| constitutive androstane receptor protein variant 3| constitutive androstane receptor protein variant 4| constitutive androstane receptor protein variant 5| constitutively transactivates RAREs| CXR| ESTM32| H920_20453| I79_014391| M91_20768| mb67| MPZ| myelin protein zero| N308_07935| nuclear receptor constitutive active receptor| Nuclear receptor subfamily 1 group I member 2| nuclear receptor subfamily 1, group I, member 3| nuclear receptor subfamily 1, group I, member 3-like protein| orphan nuclear hormone receptor| orphan nuclear receptor MB67| PAL_GLEAN10017939| PANDA_018829| strain Fischer nuclear receptor (CAR)| TREES_T100011135| UY3_16723| xenobiotic receptor| Y1Q_007015| Y956_03200| nr1i3

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