Summary of NR1I2
This gene encodes a protein that is a receptor and has both a ligand-binding domain and a DNA-binding domain (R).
The Function of NR1I2
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Protein names
Recommended name:
Nuclear receptor subfamily 1 group I member 2Short name:
SXRAlternative name(s):
Orphan nuclear receptor PAR1Orphan nuclear receptor PXR
Pregnane X receptor
Steroid and xenobiotic receptor
- RS1054191 (NR1I2) ??
- RS12721613 (NR1I2) ??
- RS1523130 (NR1I2) ??
- RS2276707 (NR1I2) ??
- RS2461823 (NR1I2) ??
- RS2472671 (NR1I2) ??
- RS35761343 (NR1I2) ??
- RS3814055 (NR1I2) ??
- RS3814057 (NR1I2) ??
- RS7643645 (NR1I2) ??
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Top Gene-Substance Interactions
NR1I2 Interacts with These Diseases
| Disease | Score |
Substances That Increase NR1I2
| Substances | Interaction | Organism | Category |
Substances That Decrease NR1I2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in liver, colon and small intestine.
Gene Pathways:
Molecular Function:
- Drug Binding
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- Steroid Hormone Receptor Activity
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Coactivator Activity
- Zinc Ion Binding
Biological Processes:
- Drug Export
- Exogenous Drug Catabolic Process
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Signal Transduction
- Steroid Metabolic Process
- Transcription Initiation From Rna Polymerase Ii Promoter
- Xenobiotic Metabolic Process
- Xenobiotic Transport
Drug Bank:
- Erlotinib
- Rifampicin
- Docetaxel
- Estradiol
- Paclitaxel
- Rifaximin
- Rilpivirine
- Vitamin E
- Ethinyl Estradiol