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  3. NR1I2

NR1I2 (Nuclear receptor subfamily 1 group I member 2)

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Summary of NR1I2

This gene encodes a protein that is a receptor and has both a ligand-binding domain and a DNA-binding domain (R). 

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The Function of NR1I2

Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

Protein names

Recommended name:

Nuclear receptor subfamily 1 group I member 2

Short name:

SXR

Alternative name(s):

Orphan nuclear receptor PAR1
Orphan nuclear receptor PXR
Pregnane X receptor
Steroid and xenobiotic receptor

NR1I2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1054191 (NR1I2) ??
  2. RS12721613 (NR1I2) ??
  3. RS1523130 (NR1I2) ??
  4. RS2276707 (NR1I2) ??
  5. RS2461823 (NR1I2) ??
  6. RS2472671 (NR1I2) ??
  7. RS35761343 (NR1I2) ??
  8. RS3814055 (NR1I2) ??
  9. RS3814057 (NR1I2) ??
  10. RS7643645 (NR1I2) ??

Top Gene-Substance Interactions

NR1I2 Interacts with These Diseases

Disease Score

Substances That Increase NR1I2

Substances Interaction Organism Category

Substances That Decrease NR1I2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB1
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Expressed in liver, colon and small intestine.

Gene Pathways:

  • Gene Expression

Molecular Function:

  • Drug Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
  • Steroid Hormone Receptor Activity
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Coactivator Activity
  • Zinc Ion Binding

Biological Processes:

  • Drug Export
  • Exogenous Drug Catabolic Process
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Signal Transduction
  • Steroid Metabolic Process
  • Transcription Initiation From Rna Polymerase Ii Promoter
  • Xenobiotic Metabolic Process
  • Xenobiotic Transport

Drug Bank:

  • Erlotinib
  • Rifampicin
  • Docetaxel
  • Estradiol
  • Paclitaxel
  • Rifaximin
  • Rilpivirine
  • Vitamin E
  • Ethinyl Estradiol
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| par1| bxr| CB1_001373019| D623_10031787| H920_07827| mPXR| nuclear receptor subfamily 1, group 1, member 2| nuclear receptor subfamily 1, group I, member 2| nuclear receptor subfamily 1 group I member 2-like protein| nuclear recptor subfamily 1 group I member 2| ONR1| orphan nuclear receptor PAR1| orphan nuclear receptor PXR| PAL_GLEAN10006517| PANDA_003272| PAR| par2| parq| pregnane X nuclear receptor variant 2| pregnane X receptor| pregnane X receptor (nuclear receptor sub family 1, group I, member 2)| PRR| PXR| PXR1| PXR.1| PXR.2| SAR| steroid and xenobiotic receptor| SXR| TREES_T100015344| xonr1| nr1i2

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