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  3. NR1H4

NR1H4 (Nuclear receptor subfamily 1 group H member 4)

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The Function of NR1H4

Isoform 4: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA.

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Protein names

Recommended name:

Bile acid receptor

Alternative name(s):

Farnesoid X-activated receptor
Farnesol receptor HRR-1
Nuclear receptor subfamily 1 group H member 4
Retinoid X receptor-interacting protein 14
RXR-interacting protein 14

NR1H4 SNPs

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  1. RS12296850 (NR1H4) ??

Top Gene-Substance Interactions

NR1H4 Interacts with These Diseases

Disease Score

Substances That Increase NR1H4

Substances Interaction Organism Category

Substances That Decrease NR1H4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • HNF-4alpha1
  • HNF-4alpha2
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • USF1

Tissue specificity:

Liver and hepatocyte-related cells express mainly FXRalpha1-type isoforms with isoform 3 and isoform 4 in approximative equal proportions. In intestine and kidney mainly FXRalpha2-type isoforms are expressed with isoform 1 and isoform 2 in approximative equal proportions. Expressed in pancreatic beta cells and macrophages.

Gene Pathways:

  • Gene Expression
  • Bile secretion

Molecular Function:

  • Bile Acid Binding
  • Bile Acid Receptor Activity
  • Chenodeoxycholic Acid Binding
  • Ligand-Dependent Nuclear Receptor Binding
  • Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
  • Sequence-Specific Dna Binding
  • Steroid Hormone Receptor Activity
  • Thyroid Hormone Receptor Activity
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Factor Binding
  • Transcription Coactivator Activity
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Zinc Ion Binding
  • Peptide Binding

Biological Processes:

  • Bile Acid And Bile Salt Transport
  • Bile Acid Metabolic Process
  • Bile Acid Signaling Pathway
  • Cell-Cell Junction Assembly
  • Cellular Response To Fatty Acid
  • Cellular Response To Lipopolysaccharide
  • Cellular Response To Organonitrogen Compound
  • Cellular Triglyceride Homeostasis
  • Defense Response To Bacterium
  • Fatty Acid Homeostasis
  • Glucose Homeostasis
  • Histone H3-R17 Methylation
  • Inflammatory Response
  • Innate Immune Response
  • Interleukin-17 Secretion
  • Intracellular Bile Acid Receptor Signaling Pathway
  • Intracellular Receptor Signaling Pathway
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Bile Acid Biosynthetic Process
  • Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Negative Regulation Of Inflammatory Response
  • Negative Regulation Of Interferon-Gamma Secretion
  • Negative Regulation Of Interleukin-1 Production
  • Negative Regulation Of Interleukin-2 Production
  • Negative Regulation Of Interleukin-6 Production
  • Negative Regulation Of Monocyte Chemotactic Protein-1 Production
  • Negative Regulation Of Nf-Kappab Transcription Factor Activity
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
  • Negative Regulation Of Tumor Necrosis Factor Secretion
  • Nitrogen Catabolite Activation Of Transcription From Rna Polymerase Ii Promoter
  • Notch Signaling Pathway
  • Positive Regulation Of Adipose Tissue Development
  • Positive Regulation Of Ammonia Assimilation Cycle
  • Positive Regulation Of Glucose Import In Response To Insulin Stimulus
  • Positive Regulation Of Glutamate Metabolic Process
  • Positive Regulation Of Insulin Receptor Signaling Pathway
  • Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Bile Acid Biosynthetic Process
  • Regulation Of Cholesterol Homeostasis
  • Regulation Of Cholesterol Metabolic Process
  • Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
  • Regulation Of Low-Density Lipoprotein Particle Clearance
  • Regulation Of Urea Metabolic Process
  • Signal Transduction
  • Toll-Like Receptor 4 Signaling Pathway
  • Toll-Like Receptor 9 Signaling Pathway
  • Transcription Initiation From Rna Polymerase Ii Promoter
  • Digestive Tract Development
  • Regulation Of Carbohydrate Metabolic Process
  • Response To Glucose
  • Response To Lipopolysaccharide

Drug Bank:

  • Chenodeoxycholic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| bar| FXR| A306_09808| AS27_12873| AS28_05564| bile acid receptor| EH28_11181| farnesoid X activated receptor| Farnesoid X-activated receptor| farnesoid X nuclear receptor| farnesoid-X-receptor alpha| farnesoid-X-receptor beta| farnesoid X receptor protein variant 1| farnesoid X receptor protein variant 2| farnesoid X receptor protein variant 3| farnesoid X receptor protein variant 4| farnesoid X receptor protein variant 5| farnesol receptor HRR-1| for2| FXRalpha| GW7_15032| H920_08335| hrr-1| HRR1| M959_13586| MDA_GLEAN10021952| N300_06630| N301_14688| N302_12844| N303_14868| N305_08142| N306_04259| N307_06697| N309_09324| N310_04952| N311_10953| N312_05360| N320_10986| N321_08809| N324_10916| N325_07547| N327_00766| N328_10874| N329_12268| N330_03306| N332_06475| N333_07218| N334_03886| N335_11884| N336_01524| N339_12008| N340_03937| N341_12489| nuclear receptor subfamily 1, group H, member 4| PAL_GLEAN10015499| PANDA_018497| PFIC5| retinoid X receptor-interacting protein 14| rip14| RXR-interacting protein 14| Rxrip14| xfor| Y1Q_021059| Y956_04082| Z169_09254| nr1h4

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