The Function of NR1H4
Isoform 4: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA.
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Protein names
Recommended name:
Bile acid receptorAlternative name(s):
Farnesoid X-activated receptorFarnesol receptor HRR-1
Nuclear receptor subfamily 1 group H member 4
Retinoid X receptor-interacting protein 14
RXR-interacting protein 14
- RS12296850 (NR1H4) ??
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Top Gene-Substance Interactions
NR1H4 Interacts with These Diseases
| Disease | Score |
Substances That Increase NR1H4
| Substances | Interaction | Organism | Category |
Substances That Decrease NR1H4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver and hepatocyte-related cells express mainly FXRalpha1-type isoforms with isoform 3 and isoform 4 in approximative equal proportions. In intestine and kidney mainly FXRalpha2-type isoforms are expressed with isoform 1 and isoform 2 in approximative equal proportions. Expressed in pancreatic beta cells and macrophages.
Gene Pathways:
Molecular Function:
- Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Factor Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Steroid Hormone Receptor Activity
- Transcription Coactivator Activity
- Transcription Corepressor Activity
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- Thyroid Hormone Receptor Activity
- Zinc Ion Binding
- Ligand-Dependent Nuclear Receptor Binding
- Bile Acid Binding
- Bile Acid Receptor Activity
- Peptide Binding
- Sequence-Specific Dna Binding
- Chenodeoxycholic Acid Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Nitrogen Catabolite Activation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Carbohydrate Metabolic Process
- Transcription Initiation From Rna Polymerase Ii Promoter
- Inflammatory Response
- Cell-Cell Junction Assembly
- Signal Transduction
- Notch Signaling Pathway
- Bile Acid Metabolic Process
- Response To Glucose
- Negative Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
- Regulation Of Low-Density Lipoprotein Particle Clearance
- Bile Acid And Bile Salt Transport
- Intracellular Receptor Signaling Pathway
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Response To Lipopolysaccharide
- Negative Regulation Of Interleukin-1 Production
- Negative Regulation Of Interleukin-2 Production
- Negative Regulation Of Interleukin-6 Production
- Toll-Like Receptor 4 Signaling Pathway
- Toll-Like Receptor 9 Signaling Pathway
- Regulation Of Urea Metabolic Process
- Histone H3-R17 Methylation
- Cellular Triglyceride Homeostasis
- Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Bile Acid Signaling Pathway
- Intracellular Bile Acid Receptor Signaling Pathway
- Glucose Homeostasis
- Defense Response To Bacterium
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Innate Immune Response
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Insulin Receptor Signaling Pathway
- Digestive Tract Development
- Negative Regulation Of Inflammatory Response
- Fatty Acid Homeostasis
- Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Regulation Of Bile Acid Biosynthetic Process
- Negative Regulation Of Bile Acid Biosynthetic Process
- Cellular Response To Lipopolysaccharide
- Cellular Response To Fatty Acid
- Cellular Response To Organonitrogen Compound
- Negative Regulation Of Monocyte Chemotactic Protein-1 Production
- Interleukin-17 Secretion
- Regulation Of Cholesterol Metabolic Process
- Negative Regulation Of Interferon-Gamma Secretion
- Positive Regulation Of Adipose Tissue Development
- Negative Regulation Of Tumor Necrosis Factor Secretion
- Regulation Of Cholesterol Homeostasis
- Positive Regulation Of Glutamate Metabolic Process
- Positive Regulation Of Ammonia Assimilation Cycle
- Positive Regulation Of Glucose Import In Response To Insulin Stimulus