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  3. NR0B2

NR0B2 (Nuclear receptor subfamily 0 group B member 2)

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The Function of NR0B2

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.

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Protein names

Recommended name:

Nuclear receptor subfamily 0 group B member 2

Alternative name(s):

Orphan nuclear receptor SHP
Small heterodimer partner

NR0B2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6659176 (NR0B2) ??

Top Gene-Substance Interactions

NR0B2 Interacts with These Diseases

Disease Score

Substances That Increase NR0B2

Substances Interaction Organism Category

Substances That Decrease NR0B2

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: ObesityFrom UniProt: Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. [MIM:601665]

     From NCBI Gene: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008] From UniProt: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • GR-alpha
  • GR-beta
  • AP-1
  • c-Jun
  • HNF-4alpha1
  • HNF-4alpha2
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Liver. Low levels of expression were detected in heart and pancreas.

Gene Pathways:

  • Gene Expression
  • Bile secretion

Molecular Function:

  • Dna Binding
  • Protein Domain Specific Binding
  • Protein Homodimerization Activity
  • Steroid Hormone Receptor Activity
  • Transcription Corepressor Activity
  • Transcription Factor Binding

Biological Processes:

  • Animal Organ Regeneration
  • Cholesterol Metabolic Process
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Notch Signaling Pathway
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Insulin Secretion
  • Response To Glucose
  • Transcription Initiation From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_13605| AS28_10440| CB1_000129005| EGK_00429| H920_00860| M91_13418| N300_05826| N301_13584| N302_13896| N303_00259| N305_08355| N307_14741| N308_12887| N309_08897| N322_05585| N325_07455| N326_07471| N329_06421| N330_10385| N332_08615| N333_00243| N334_08521| N335_09128| N336_06050| N340_10159| NROB2| nuclear receptor SHP| nuclear receptor subfamily 0, group B, member 2| nuclear receptor subfamily 0 group B member 2-like protein| orphan nuclear receptor SHP| PAL_GLEAN10015094| PANDA_001162| short heterodimer partner| SHP| SHP1| SHP-1| small heterodimer partner| small heterodimer partner homologue| TREES_T100021849| Y1Q_005609| Y956_14885| Z169_00180| nr0b2

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