Disease	Score

Substances	Interaction	Organism	Category

Substances	Interaction	Organism	Category

     From NCBI Gene: ObesityFrom UniProt: Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. [MIM:601665]

     From NCBI Gene: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008] From UniProt: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

Condition	Change (log2fold)	Comparison	Species	Experimental variables	Experiment name

The following transcription factors affect gene expression:

• ER-alpha
• GR-alpha
• GR-beta
• AP-1
• c-Jun
• HNF-4alpha1
• HNF-4alpha2
• SREBP-1a
• SREBP-1c
• SREBP-1b

Tissue specificity:

Liver. Low levels of expression were detected in heart and pancreas.

Molecular Function:

• Dna Binding
• Steroid Hormone Receptor Activity
• Transcription Corepressor Activity
• Transcription Factor Binding
• Protein Domain Specific Binding
• Protein Homodimerization Activity

Biological Processes:

• Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
• Transcription Initiation From Rna Polymerase Ii Promoter
• Notch Signaling Pathway
• Cholesterol Metabolic Process
• Response To Glucose
• Positive Regulation Of Gene Expression
• Negative Regulation Of Gene Expression
• Animal Organ Regeneration
• Positive Regulation Of Insulin Secretion
• Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity

*synonyms