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  3. NPPB

NPPB (Natriuretic peptide B)

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Summary of NPPB

Natriuretic peptide precursor B (NPPB) is associated with blood pressure and body fluid homeostasis. [R] NPPB lowers blood pressure. High concentration of this protein is indicative of heart failure.

NPPB is a heart hormone which may protect against tissue scarring in the heart. It inhibits renin and aldosterone secretion and facilitates the excretion of salt and water.  It induces vasorelaxation. [R]

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The Function of NPPB

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Protein names

Recommended name:

Natriuretic peptides B

Short name:

1-30

Alternative name(s):

Gamma-brain natriuretic peptide
BNP(1-32
BNP-32
1-29
1-28
2-31
3-32
3-30
3-29
4-32
4-31
4-30
4-29
4-27
5-32
5-31
5-29

NPPB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS198388 (NPPB) ??
  2. RS198389 (NPPB) ??

Top Gene-Substance Interactions

NPPB Interacts with These Diseases

Disease Score

Fixes

If low NPPB: Take vasodilators, or substances that dilate the blood vessels to decrease blood pressure, such as exercise, diet, diuretics [R] and potassium [R].

Substances That Increase NPPB

Substances Interaction Organism Category

Substances That Decrease NPPB

Substances Interaction Organism Category

Advanced Summary

Natriuretic peptide precursor B (NPPB). NPPB gene is associated with blood pressure and body fluid homeostasis. [R] NPPB lowers blood pressure. High concentration of this protein is indicative of heart failure. Mutations of this gene are associated with postmenopausal osteoporosis. [R] Increased levels of NPPB is found in the blood when heart conditions are worse. Lower levels when heart condition is stable. NPPB is secreted by ventricles of the heart in response to changes in blood pressure associated with heart failure.  Concentration of NPPB is tested and used for diagnosis of heart failure. NBBP is secreted by the ventricles of the heart [R] Diseases associated with NPPB are sleep apnea and Chronic Thromboembolic Pulmonary Hypertension. [R] NPPB is a heart hormone which may protect against tissue scarring in the heart. It inhibits renin and aldosterone secretion and facilitates the excretion of salt and water.  It induces vasorelaxation. [R] NPPB is used as a diagnostic tool for hypertrophy and heart failure. PPB biological function includes decreasing rate of formation of blood vessels and cell growth.[R]

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • NF-kappaB1

Tissue specificity:

Brain and also in atria, but at much lower levels than ANP.

Gene Pathways:

  • Vascular smooth muscle contraction

Molecular Function:

  • Diuretic Hormone Activity
  • Hormone Activity
  • Receptor Binding

Biological Processes:

  • Body Fluid Secretion
  • Cell Surface Receptor Signaling Pathway
  • Cgmp Biosynthetic Process
  • Negative Regulation Of Angiogenesis
  • Negative Regulation Of Cell Growth
  • Positive Regulation Of Renal Sodium Excretion
  • Positive Regulation Of Urine Volume
  • Receptor Guanylyl Cyclase Signaling Pathway
  • Regulation Of Blood Pressure
  • Regulation Of Vascular Permeability
  • Regulation Of Vasodilation

Drug Bank:

  • Carvedilol
  • Oxymetholone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ANP| atrial natriuretic factor| B-type natriuretic peptide| natriuretic peptide precursor A| nppb| ANF| atrial natriuretic peptide| bnf| BNP| BNP1| Brain natriuretic factor| brain natriuretic peptide| brain type natriuretic peptide| CB1_001783021| cnp-2| C-type natriuretic peptide 2| D623_10022026| Gamma-brain natriuretic peptide| iso-ANP| M91_08658| natriuretic peptide B preproprotein| natriuretic peptide precursor B| natriuretic peptide precursor type B| natriuretic peptides A| Natriuretic peptides B| natriuretic peptide type B| natriuretic protein| NPPA| PAL_GLEAN10012986| prepronatriodilatin| type-B natriuretic factor| zmp:0000000639

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