Summary of NPPB
Natriuretic peptide precursor B (NPPB) is associated with blood pressure and body fluid homeostasis. [R] NPPB lowers blood pressure. High concentration of this protein is indicative of heart failure.
NPPB is a heart hormone which may protect against tissue scarring in the heart. It inhibits renin and aldosterone secretion and facilitates the excretion of salt and water. It induces vasorelaxation. [R]
The Function of NPPB
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Protein names
Recommended name:
Natriuretic peptides BShort name:
1-30Alternative name(s):
Gamma-brain natriuretic peptideBNP(1-32
BNP-32
1-29
1-28
2-31
3-32
3-30
3-29
4-32
4-31
4-30
4-29
4-27
5-32
5-31
5-29
- RS198388 (NPPB) ??
- RS198389 (NPPB) ??
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Top Gene-Substance Interactions
NPPB Interacts with These Diseases
| Disease | Score |
Fixes
Substances That Increase NPPB
| Substances | Interaction | Organism | Category |
Substances That Decrease NPPB
| Substances | Interaction | Organism | Category |
Advanced Summary
Natriuretic peptide precursor B (NPPB). NPPB gene is associated with blood pressure and body fluid homeostasis. [R] NPPB lowers blood pressure. High concentration of this protein is indicative of heart failure. Mutations of this gene are associated with postmenopausal osteoporosis. [R] Increased levels of NPPB is found in the blood when heart conditions are worse. Lower levels when heart condition is stable. NPPB is secreted by ventricles of the heart in response to changes in blood pressure associated with heart failure. Concentration of NPPB is tested and used for diagnosis of heart failure. NBBP is secreted by the ventricles of the heart [R] Diseases associated with NPPB are sleep apnea and Chronic Thromboembolic Pulmonary Hypertension. [R] NPPB is a heart hormone which may protect against tissue scarring in the heart. It inhibits renin and aldosterone secretion and facilitates the excretion of salt and water. It induces vasorelaxation. [R] NPPB is used as a diagnostic tool for hypertrophy and heart failure. PPB biological function includes decreasing rate of formation of blood vessels and cell growth.[R]
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Brain and also in atria, but at much lower levels than ANP.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cgmp Biosynthetic Process
- Cell Surface Receptor Signaling Pathway
- Receptor Guanylyl Cyclase Signaling Pathway
- Body Fluid Secretion
- Regulation Of Blood Pressure
- Negative Regulation Of Angiogenesis
- Negative Regulation Of Cell Growth
- Positive Regulation Of Urine Volume
- Positive Regulation Of Renal Sodium Excretion
- Regulation Of Vasodilation
- Regulation Of Vascular Permeability