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  3. NOX4

NOX4 (NADPH oxidase 4)

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The Function of NOX4

Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.

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Protein names

Recommended name:

NADPH oxidase 4

Short name:

KOX-1

Alternative name(s):

Kidney oxidase-1
Kidney superoxide-producing NADPH oxidase
Renal NAD(P

NOX4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10830265 (NOX4) ??
  2. RS1488902 (NOX4) ??
  3. RS7130284 (NOX4) ??
  4. RS957140 (NOX4) ??

Top Gene-Substance Interactions

NOX4 Interacts with These Diseases

Disease Score

Substances That Increase NOX4

Substances Interaction Organism Category

Substances That Decrease NOX4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1

Tissue specificity:

Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells.

Induction:

By 7-ketocholesterol (at protein level).

Developmental stage:

Expressed in fetal kidney and fetal liver.

Enzyme Regulation:

Inhibited by plumbagin (By similarity). Activated by phorbol 12-myristate 13-acetate (PMA). Activated by insulin. Inhibited by diphenylene iodonium.

Molecular Function:

  • Electron Carrier Activity
  • Flavin Adenine Dinucleotide Binding
  • Heme Binding
  • Modified Amino Acid Binding
  • Nad(P)H Oxidase Activity
  • Nucleotide Binding
  • Oxygen Sensor Activity
  • Superoxide-Generating Nadph Oxidase Activity

Biological Processes:

  • Bone Resorption
  • Cardiac Muscle Cell Differentiation
  • Cell Aging
  • Cell Morphogenesis
  • Cellular Response To Camp
  • Cellular Response To Gamma Radiation
  • Cellular Response To Glucose Stimulus
  • Cellular Response To Transforming Growth Factor Beta Stimulus
  • Gene Expression
  • Homocysteine Metabolic Process
  • Inflammatory Response
  • Negative Regulation Of Cell Proliferation
  • Oxidation-Reduction Process
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Dna Biosynthetic Process
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Map Kinase Activity
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Positive Regulation Of Smooth Muscle Cell Migration
  • Positive Regulation Of Stress Fiber Assembly
  • Reactive Oxygen Species Metabolic Process
  • Response To Hypoxia
  • Response To Reactive Oxygen Species
  • Superoxide Anion Generation
  • Superoxide Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_12009| AS27_09789| AS28_02558| CB1_001776002| GW7_08082| H920_09381| I79_020362| kidney oxidase-1| kidney superoxide-producing NADPH oxidase| kox| kox-1| M959_07846| MDA_GLEAN10008068| N300_01726| N301_00133| N302_10823| N303_02011| N305_02831| N306_00094| N307_09395| N308_04767| N311_12351| N312_03821| N320_11558| N322_11420| N324_11486| N325_12772| N326_12021| N327_12829| N328_02045| N330_08795| N331_01587| N339_01236| N340_03877| N341_01912| PAL_GLEAN10025580| PANDA_017732| predicted NADPH oxidase-4| renal NAD(P)H-oxidase| RENOX| superoxide-generating NADPH oxidase 4| TREES_T100018798| UY3_10190| Y1Q_012943| Y956_13407| Z169_01829| nox4

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