The Function of NOX4
Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.
Protein names
Recommended name:
NADPH oxidase 4Short name:
KOX-1Alternative name(s):
Kidney oxidase-1Kidney superoxide-producing NADPH oxidase
Renal NAD(P
- RS10830265 (NOX4) ??
- RS1488902 (NOX4) ??
- RS7130284 (NOX4) ??
- RS957140 (NOX4) ??
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Top Gene-Substance Interactions
NOX4 Interacts with These Diseases
| Disease | Score |
Substances That Increase NOX4
| Substances | Interaction | Organism | Category |
Substances That Decrease NOX4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells.
Induction:
By 7-ketocholesterol (at protein level).
Developmental stage:
Expressed in fetal kidney and fetal liver.
Enzyme Regulation:
Inhibited by plumbagin (By similarity). Activated by phorbol 12-myristate 13-acetate (PMA). Activated by insulin. Inhibited by diphenylene iodonium.
Molecular Function:
- Nucleotide Binding
- Electron Carrier Activity
- Nad(P)H Oxidase Activity
- Superoxide-Generating Nadph Oxidase Activity
- Oxygen Sensor Activity
- Heme Binding
- Flavin Adenine Dinucleotide Binding
- Modified Amino Acid Binding
Biological Processes:
- Response To Reactive Oxygen Species
- Cell Morphogenesis
- Response To Hypoxia
- Superoxide Metabolic Process
- Inflammatory Response
- Cell Aging
- Negative Regulation Of Cell Proliferation
- Gene Expression
- Positive Regulation Of Smooth Muscle Cell Migration
- Superoxide Anion Generation
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Map Kinase Activity
- Bone Resorption
- Homocysteine Metabolic Process
- Positive Regulation Of Stress Fiber Assembly
- Positive Regulation Of Protein Kinase B Signaling
- Cardiac Muscle Cell Differentiation
- Oxidation-Reduction Process
- Positive Regulation Of Erk1 And Erk2 Cascade
- Cellular Response To Camp
- Cellular Response To Glucose Stimulus
- Cellular Response To Gamma Radiation
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Reactive Oxygen Species Metabolic Process
- Positive Regulation Of Reactive Oxygen Species Metabolic Process
- Positive Regulation Of Dna Biosynthetic Process