Summary of NOTCH4
NOTCH4 encodes a NOTCH protein, which is involved in intercellular signaling pathways that regulate interactions between physically adjacent cells. Mutations of this gene are associated with higher risk for schizophrenia (R).
The Function of NOTCH4
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
Protein names
Recommended name:
Neurogenic locus notch homolog protein 4Alternative name(s):
Notch 4hNotch4
- RS13215567 (NOTCH4) ??
- RS2071277 (NOTCH4) ??
- RS2071278 (NOTCH4) ??
- RS2071286 (NOTCH4) ??
- RS3096702 (NOTCH4) ??
- RS3115573 (NOTCH4) ??
- RS3130320 (NOTCH4) ??
- RS3131296 (NOTCH4) ??
- RS3132935 (NOTCH4) ??
- RS3132946 (NOTCH4) ??
- RS3134931 (NOTCH4) ??
- RS404860 (NOTCH4) ??
- RS419132 (NOTCH4) ??
- RS422951 (NOTCH4) ??
- RS424232 (NOTCH4) ??
- RS438475 (NOTCH4) ??
- RS443198 (NOTCH4) ??
- RS549182 (NOTCH4) ??
- RS6936204 (NOTCH4) ??
- RS9267911 (NOTCH4) ??
- RS9267972 (NOTCH4) ??
- RS9296015 (NOTCH4) ??
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Top Gene-Substance Interactions
NOTCH4 Interacts with These Diseases
| Disease | Score |
Substances That Increase NOTCH4
| Substances | Interaction | Organism | Category |
Substances That Decrease NOTCH4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
Gene Pathways:
Molecular Function:
Biological Processes:
- Branching Involved In Blood Vessel Morphogenesis
- Cell Fate Determination
- Morphogenesis Of A Branching Structure
- Endothelial Cell Morphogenesis
- Transcription Initiation From Rna Polymerase Ii Promoter
- Notch Signaling Pathway
- Notch Receptor Processing
- Positive Regulation Of Transcription Of Notch Receptor Target
- Embryo Development
- Hemopoiesis
- Cell Differentiation
- Mammary Gland Development
- Negative Regulation Of Cell Differentiation
- Negative Regulation Of Endothelial Cell Differentiation
- Positive Regulation Of Transcription, Dna-Templated