Summary of NOTCH4
The NOTCH4 gene encodes notch receptor 4 It is one of several types of notch proteins [R].
NOTCH4 is involved in intercellular signalling pathways. In other words, it helps cells communicate with other nearby cells. This gene may also play a role in the development of the kidney, liver, and blood vessels. It has also been implicated in severe COVID-19 infection [R, R].
Variants in NOTCH4 have been linked to [R, R, R, R, R, R]:
- Schizophrenia
- Bipolar disorder
- Asthma
- Age-related macular degeneration
- Systemic sclerosis
- COVID-19 severity
Protein names
Recommended name:
Neurogenic locus notch homolog protein 4Alternative name(s):
Notch 4hNotch4
- RS13215567 (NOTCH4) ??
- RS2071277 (NOTCH4) ??
- RS2071278 (NOTCH4) ??
- RS2071286 (NOTCH4) ??
- RS3096702 (NOTCH4) ??
- RS3115573 (NOTCH4) ??
- RS3130320 (NOTCH4) ??
- RS3131296 (NOTCH4) ??
- RS3132935 (NOTCH4) ??
- RS3132946 (NOTCH4) ??
- RS3134931 (NOTCH4) ??
- RS396960 (NOTCH4) ??
- RS404860 (NOTCH4) ??
- RS419132 (NOTCH4) ??
- RS422951 (NOTCH4) ??
- RS424232 (NOTCH4) ??
- RS438475 (NOTCH4) ??
- RS443198 (NOTCH4) ??
- RS549182 (NOTCH4) ??
- RS6936204 (NOTCH4) ??
- RS9267911 (NOTCH4) ??
- RS9267972 (NOTCH4) ??
- RS9296015 (NOTCH4) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
NOTCH4 Interacts with These Diseases
| Disease | Score |
Substances That Increase NOTCH4
| Substances | Interaction | Organism | Category |
Substances That Decrease NOTCH4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
Gene Pathways:
Molecular Function:
Biological Processes:
- Branching Involved In Blood Vessel Morphogenesis
- Cell Fate Determination
- Morphogenesis Of A Branching Structure
- Endothelial Cell Morphogenesis
- Transcription Initiation From Rna Polymerase Ii Promoter
- Notch Signaling Pathway
- Notch Receptor Processing
- Positive Regulation Of Transcription Of Notch Receptor Target
- Embryo Development
- Hemopoiesis
- Cell Differentiation
- Mammary Gland Development
- Negative Regulation Of Cell Differentiation
- Negative Regulation Of Endothelial Cell Differentiation
- Positive Regulation Of Transcription, Dna-Templated