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  3. NOTCH4

NOTCH4 (Notch 4)

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Summary of NOTCH4

NOTCH4 encodes a NOTCH protein, which is involved in intercellular signaling pathways that regulate interactions between physically adjacent cells. Mutations of this gene are associated with higher risk for schizophrenia (R). 

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The Function of NOTCH4

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.

Protein names

Recommended name:

Neurogenic locus notch homolog protein 4

Alternative name(s):

Notch 4
hNotch4

NOTCH4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13215567 (NOTCH4) ??
  2. RS2071277 (NOTCH4) ??
  3. RS2071278 (NOTCH4) ??
  4. RS2071286 (NOTCH4) ??
  5. RS3096702 (NOTCH4) ??
  6. RS3115573 (NOTCH4) ??
  7. RS3130320 (NOTCH4) ??
  8. RS3131296 (NOTCH4) ??
  9. RS3132935 (NOTCH4) ??
  10. RS3132946 (NOTCH4) ??
  11. RS3134931 (NOTCH4) ??
  12. RS404860 (NOTCH4) ??
  13. RS419132 (NOTCH4) ??
  14. RS422951 (NOTCH4) ??
  15. RS424232 (NOTCH4) ??
  16. RS438475 (NOTCH4) ??
  17. RS443198 (NOTCH4) ??
  18. RS549182 (NOTCH4) ??
  19. RS6936204 (NOTCH4) ??
  20. RS9267911 (NOTCH4) ??
  21. RS9267972 (NOTCH4) ??
  22. RS9296015 (NOTCH4) ??

Top Gene-Substance Interactions

NOTCH4 Interacts with These Diseases

Disease Score

Substances That Increase NOTCH4

Substances Interaction Organism Category

Substances That Decrease NOTCH4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.

Gene Pathways:

  • Signal Transduction
  • Gene Expression
  • Dorso-ventral axis formation
  • NICD traffics to nucleus
  • Notch signaling pathway
  • A third proteolytic cleavage releases NICD
  • Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

Molecular Function:

  • Calcium Ion Binding
  • Protein Heterodimerization Activity
  • Receptor Activity

Biological Processes:

  • Cell Differentiation
  • Cell Fate Determination
  • Embryo Development
  • Endothelial Cell Morphogenesis
  • Hemopoiesis
  • Mammary Gland Development
  • Morphogenesis Of A Branching Structure
  • Negative Regulation Of Cell Differentiation
  • Negative Regulation Of Endothelial Cell Differentiation
  • Notch Receptor Processing
  • Notch Signaling Pathway
  • Branching Involved In Blood Vessel Morphogenesis
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription Of Notch Receptor Target
  • Transcription Initiation From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| G-protein-signaling modulator 3| D623_10007210| H920_17575| Int-3| INT3| MDA_GLEAN10005662| N4| Neurogenic locus notch 4| neurogenic locus notch homolog protein 4| neurogenic locus notch homolog protein 4 preproprotein| Neurogenic locus notch like protein 4| Notch gene homolog 4| Notch homolog 4| PAL_GLEAN10001044| PANDA_019931| putative Notch4 protein| notch4

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