Summary of NOS3
The NOS3 gene encodes nitric oxide synthase 3 or eNOS [R].
eNOS produces nitric oxide in our blood vessels, which helps to expand them (vasodilation). Nitric oxide also promotes blood clotting and helps with the formation of new blood vessels [R].
NOS3 mutations have been linked to several diseases, including [R]:
- Coronary spasm
- Stroke
- Alzheimer's disease
- High blood pressure
- High blood pressure & seizures during pregnancy (pre-eclampsia & eclampsia)
Nitric oxide is also involved in:
- Communication between nerve cells (neurotransmission)
- Killing microbes (antimicrobial activity)
- Preventing tumors from forming (antitumoral activity)
It's better to have this gene increased
most of the time.
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Protein names
Recommended name:
Nanos homolog 3Short name:
NOS-3- R3918226 (NOS3) ??
- RS1799983 (NOS3) ??
- RS1800779 (NOS3) ??
- RS1800783 (NOS3) ??
- RS2070744 (NOS3) ??
- RS3918188 (NOS3) ??
- RS3918226 (NOS3) ??
- RS3918227 (NOS3) ??
- RS743506 (NOS3) ??
- RS743507 (NOS3) ??
- RS891512 (NOS3) ??
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Top Gene-Substance Interactions
NOS3 Interacts with These Diseases
| Disease | Score |
Substances That Increase NOS3
| Substances | Interaction | Organism | Category |
Substances That Decrease NOS3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Platelets, placenta, liver and kidney.
Gene Pathways:
Enzyme Regulation:
Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.
Cofactor:
Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
Molecular Function:
- Actin Monomer Binding
- Arginine Binding
- Cadmium Ion Binding
- Flavin Adenine Dinucleotide Binding
- Fmn Binding
- Heme Binding
- Iron Ion Binding
- Nadp Binding
- Nitric-Oxide Synthase Activity
- Tetrahydrobiopterin Binding
- Rna Binding
- Zinc Ion Binding
Biological Processes:
- Angiogenesis
- Arginine Catabolic Process
- Blood Vessel Remodeling
- Cell Redox Homeostasis
- Endothelial Cell Migration
- In Utero Embryonic Development
- Lipopolysaccharide-Mediated Signaling Pathway
- Lung Development
- Mitochondrion Organization
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Calcium Ion Transport
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Hydrolase Activity
- Negative Regulation Of Muscle Hyperplasia
- Negative Regulation Of Platelet Activation
- Negative Regulation Of Potassium Ion Transport
- Nitric Oxide Biosynthetic Process
- Nitric Oxide Mediated Signal Transduction
- Ovulation From Ovarian Follicle
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Guanylate Cyclase Activity
- Positive Regulation Of Vasodilation
- Regulation Of Blood Pressure
- Regulation Of Blood Vessel Size
- Regulation Of Nitric-Oxide Synthase Activity
- Regulation Of Sodium Ion Transport
- Regulation Of Systemic Arterial Blood Pressure By Endothelin
- Regulation Of The Force Of Heart Contraction By Chemical Signal
- Removal Of Superoxide Radicals
- Response To Fluid Shear Stress
- Response To Heat
- Smooth Muscle Hyperplasia
- Germ Cell Development
- Multicellular Organism Development
- Negative Regulation Of Apoptotic Signaling Pathway
- Negative Regulation Of Translation
- Oogenesis
- Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
- Regulation Of Cell Cycle
- Regulation Of Translation
- Spermatogenesis