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  3. NOS3

NOS3 (Nitric oxide synthase 3)

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Summary of NOS3

NOS3, also known as eNOS, produces nitric oxide in our blood vessels, which helps vasodilation and mediates formation of blood vessels, and promotes blood clotting by activating platelets (R).

NOS3 is associated with these diseases:

  • Coronary spasm
  • Ischemic stroke
  • Alzheimer's disease
  • Preeclampsia/eclampsia
  • Essential hypertension

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities.

Nitric oxide is synthesized from L-arginine by nitric oxide synthases.

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Protein names

Recommended name:

Nanos homolog 3

Short name:

NOS-3

NOS3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. R3918226 (NOS3) ??
  2. RS1799983 (NOS3) ??
  3. RS1800779 (NOS3) ??
  4. RS1800783 (NOS3) ??
  5. RS2070744 (NOS3) ??
  6. RS3918188 (NOS3) ??
  7. RS3918226 (NOS3) ??
  8. RS3918227 (NOS3) ??
  9. RS743506 (NOS3) ??
  10. RS743507 (NOS3) ??
  11. RS891512 (NOS3) ??

Top Gene-Substance Interactions

NOS3 Interacts with These Diseases

Disease Score

Substances That Increase NOS3

Substances Interaction Organism Category

Substances That Decrease NOS3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • STAT3
  • NF-kappaB1
  • Sp1
  • FOXO1a
  • FOXO1

Tissue specificity:

Platelets, placenta, liver and kidney.

Gene Pathways:

  • Metabolic pathways
  • Hemostasis
  • Disease
  • Arginine and proline metabolism
  • Calcium signaling pathway
  • VEGF signaling pathway
  • Signal Transduction
  • Metabolism

Enzyme Regulation:

Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.

Cofactor:

Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.

Molecular Function:

  • Actin Monomer Binding
  • Arginine Binding
  • Cadmium Ion Binding
  • Flavin Adenine Dinucleotide Binding
  • Fmn Binding
  • Heme Binding
  • Iron Ion Binding
  • Nadp Binding
  • Nitric-Oxide Synthase Activity
  • Tetrahydrobiopterin Binding
  • Rna Binding
  • Zinc Ion Binding

Biological Processes:

  • Angiogenesis
  • Arginine Catabolic Process
  • Blood Vessel Remodeling
  • Cell Redox Homeostasis
  • Endothelial Cell Migration
  • In Utero Embryonic Development
  • Lipopolysaccharide-Mediated Signaling Pathway
  • Lung Development
  • Mitochondrion Organization
  • Negative Regulation Of Blood Pressure
  • Negative Regulation Of Calcium Ion Transport
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Negative Regulation Of Hydrolase Activity
  • Negative Regulation Of Muscle Hyperplasia
  • Negative Regulation Of Platelet Activation
  • Negative Regulation Of Potassium Ion Transport
  • Nitric Oxide Biosynthetic Process
  • Nitric Oxide Mediated Signal Transduction
  • Ovulation From Ovarian Follicle
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Guanylate Cyclase Activity
  • Positive Regulation Of Vasodilation
  • Regulation Of Blood Pressure
  • Regulation Of Blood Vessel Size
  • Regulation Of Nitric-Oxide Synthase Activity
  • Regulation Of Sodium Ion Transport
  • Regulation Of Systemic Arterial Blood Pressure By Endothelin
  • Regulation Of The Force Of Heart Contraction By Chemical Signal
  • Removal Of Superoxide Radicals
  • Response To Fluid Shear Stress
  • Response To Heat
  • Smooth Muscle Hyperplasia
  • Germ Cell Development
  • Multicellular Organism Development
  • Negative Regulation Of Apoptotic Signaling Pathway
  • Negative Regulation Of Translation
  • Oogenesis
  • Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
  • Regulation Of Cell Cycle
  • Regulation Of Translation
  • Spermatogenesis

Drug Bank:

  • L-Arginine
  • Apremilast
  • L-Citrulline
  • Miconazole
  • Tetrahydrobiopterin
  • Doxorubicin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| constitutive NOS| NOS| nitric oxide synthase 2, inducible| CB1_001387006| cNOS| ecNOS| EC-NOS| endothelial nitric oxide synthase| endothelial nitric oxide synthase 3| endothelial nitric oxide synthase NOS3| endothelial NOS| endothelia NO synthase| eNOS| GW7_02044| H920_10982| I79_007693| MDA_GLEAN10012202| N307_09075| nitric oxide synthase 3 (endothelial cell)| nitric oxide synthase 3, endothelial cell| nitric oxide synthase 3 transcript variant eNOS-delta20| nitric oxide synthase 3 transcript variant eNOS-delta20-21| nitric oxide synthase 3 transcript variant eNOS-delta21| nitric oxide synthase, endothelial| NOS2| Nos-3| NOSIII| NOS type III| PAL_GLEAN10007554| PANDA_003554| TREES_T100003011| Y1Q_010821| nos3

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