Summary of NOS3
NOS3, also known as eNOS, produces nitric oxide in our blood vessels, which helps vasodilation and mediates formation of blood vessels, and promotes blood clotting by activating platelets (R).
NOS3 is associated with these diseases:
- Coronary spasm
- Ischemic stroke
- Alzheimer's disease
- Preeclampsia/eclampsia
- Essential hypertension
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities.
Nitric oxide is synthesized from L-arginine by nitric oxide synthases.
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Protein names
Recommended name:
Nanos homolog 3Short name:
NOS-3- R3918226 (NOS3) ??
- RS1799983 (NOS3) ??
- RS1800779 (NOS3) ??
- RS1800783 (NOS3) ??
- RS2070744 (NOS3) ??
- RS3918188 (NOS3) ??
- RS3918226 (NOS3) ??
- RS3918227 (NOS3) ??
- RS743506 (NOS3) ??
- RS743507 (NOS3) ??
- RS891512 (NOS3) ??
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Top Gene-Substance Interactions
NOS3 Interacts with These Diseases
| Disease | Score |
Substances That Increase NOS3
| Substances | Interaction | Organism | Category |
Substances That Decrease NOS3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Platelets, placenta, liver and kidney.
Gene Pathways:
Enzyme Regulation:
Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.
Cofactor:
Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
Molecular Function:
- Actin Monomer Binding
- Arginine Binding
- Cadmium Ion Binding
- Flavin Adenine Dinucleotide Binding
- Fmn Binding
- Heme Binding
- Iron Ion Binding
- Nadp Binding
- Nitric-Oxide Synthase Activity
- Tetrahydrobiopterin Binding
- Rna Binding
- Zinc Ion Binding
Biological Processes:
- Angiogenesis
- Arginine Catabolic Process
- Blood Vessel Remodeling
- Cell Redox Homeostasis
- Endothelial Cell Migration
- In Utero Embryonic Development
- Lipopolysaccharide-Mediated Signaling Pathway
- Lung Development
- Mitochondrion Organization
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Calcium Ion Transport
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Hydrolase Activity
- Negative Regulation Of Muscle Hyperplasia
- Negative Regulation Of Platelet Activation
- Negative Regulation Of Potassium Ion Transport
- Nitric Oxide Biosynthetic Process
- Nitric Oxide Mediated Signal Transduction
- Ovulation From Ovarian Follicle
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Guanylate Cyclase Activity
- Positive Regulation Of Vasodilation
- Regulation Of Blood Pressure
- Regulation Of Blood Vessel Size
- Regulation Of Nitric-Oxide Synthase Activity
- Regulation Of Sodium Ion Transport
- Regulation Of Systemic Arterial Blood Pressure By Endothelin
- Regulation Of The Force Of Heart Contraction By Chemical Signal
- Removal Of Superoxide Radicals
- Response To Fluid Shear Stress
- Response To Heat
- Smooth Muscle Hyperplasia
- Germ Cell Development
- Multicellular Organism Development
- Negative Regulation Of Apoptotic Signaling Pathway
- Negative Regulation Of Translation
- Oogenesis
- Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
- Regulation Of Cell Cycle
- Regulation Of Translation
- Spermatogenesis