• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. NOS2

NOS2 (Nitric oxide synthase 2)

Loading...

Summary of NOS2

NOS2 encodes Inducible NOS (iNOS) in the immune system and cardiovascular system. It helps in immune defense against pathogens by producing nitric oxide. a free radical.

NOS2 helps neurotransmission and has antimicrobial and antitumor activities (R).

NOS2 contributes to inflammation, by enhancing the synthesis of inflammatory cytokines such as IL6 and IL8. It's also induced by inflammation.

Nitric oxide lowers blood pressure.

This gene is associated with hypertension and susceptibility to malaria.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Nanos homolog 2

Short name:

NOS-2

NOS2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1137933 (NOS2) ??
  2. RS11653716 (NOS2) ??
  3. RS2248814 (NOS2) ??
  4. RS2297518 (NOS2) ??
  5. RS3729508 (NOS2) ??
  6. RS4795067 (NOS2) ??
  7. RS8072199 (NOS2) ??
  8. RS8078340 (NOS2) ??
  9. RS944722 (NOS2) ??

Top Gene-Substance Interactions

NOS2 Interacts with These Diseases

Disease Score

Substances That Increase NOS2

Substances Interaction Organism Category

Substances That Decrease NOS2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AhR
  • NF-kappaB1
  • C/EBPbeta
  • HNF-4alpha1
  • HNF-4alpha2
  • IRF-1
  • RelA
  • p300

Tissue specificity:

Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Gene Pathways:

  • Metabolic pathways
  • Hemostasis
  • Small cell lung cancer
  • Chagas disease (American trypanosomiasis)
  • Tuberculosis
  • Toxoplasmosis
  • Pathways in cancer
  • Leishmaniasis
  • Disease
  • Arginine and proline metabolism
  • Calcium signaling pathway
  • Amoebiasis
  • Peroxisome

Induction:

By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta (PubMed:7528267). Down-regulated by zinc due to inhibition of NF-kappa-B transactivation activity (PubMed:25180171). By oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112).

Enzyme Regulation:

Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity.

Cofactor:

Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.

Molecular Function:

  • Mrna Binding
  • Zinc Ion Binding
  • Arginine Binding
  • Flavin Adenine Dinucleotide Binding
  • Fmn Binding
  • Heme Binding
  • Metal Ion Binding
  • Nadp Binding
  • Nitric-Oxide Synthase Activity
  • Protein Homodimerization Activity
  • Receptor Binding
  • Tetrahydrobiopterin Binding

Biological Processes:

  • Cell Differentiation
  • Germ-Line Stem Cell Population Maintenance
  • Mrna Catabolic Process
  • Multicellular Organism Development
  • Negative Regulation Of Meiotic Nuclear Division
  • Negative Regulation Of Translation
  • Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
  • Spermatogenesis
  • Arginine Catabolic Process
  • Cell Redox Homeostasis
  • Cellular Response To Interferon-Gamma
  • Cellular Response To Lipopolysaccharide
  • Circadian Rhythm
  • Defense Response To Bacterium
  • Defense Response To Gram-Negative Bacterium
  • Innate Immune Response In Mucosa
  • Interleukin-6 Secretion
  • Interleukin-8 Secretion
  • Negative Regulation Of Blood Pressure
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Protein Catabolic Process
  • Nitric Oxide Biosynthetic Process
  • Nitric Oxide Mediated Signal Transduction
  • Peptidyl-Cysteine S-Nitrosylation
  • Positive Regulation Of Guanylate Cyclase Activity
  • Positive Regulation Of Killing Of Cells Of Other Organism
  • Positive Regulation Of Leukocyte Mediated Cytotoxicity
  • Positive Regulation Of Vasodilation
  • Prostaglandin Secretion
  • Regulation Of Cell Proliferation
  • Regulation Of Cellular Respiration
  • Regulation Of Cytokine Production Involved In Inflammatory Response
  • Regulation Of Insulin Secretion
  • Response To Bacterium
  • Response To Hypoxia
  • Superoxide Metabolic Process

Drug Bank:

  • L-Arginine
  • Dexamethasone
  • Doxorubicin
  • L-Citrulline
  • Miconazole
  • Triflusal
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| NOS| AS27_13553| AS28_09419| BmNOS2| CB1_000765065| H920_13098| hepatocyte NOS| HEP-NOS| inducible nitric oxide synthase| inducible nitric oxide synthase NOS2| inducible NOS| inducible NO synthase| iNOS| i-NOS| M91_10448| MAC-NOS| macrophage NOS| MDA_GLEAN10000973| N300_04257| N301_08119| N302_07659| N305_07211| N306_15610| N307_14195| N308_14353| N309_01799| N312_00647| N320_08208| N321_13845| N324_05498| N327_12140| N328_11658| N330_13282| N331_02447| N334_03596| N336_06570| N341_12711| nitric-oxide synthase| nitric oxide synthase 2A| nitric oxide synthase 2A (inducible, hepatocytes)| Nitric oxide synthase 2b1| nitric oxide synthase 2, inducible| nitric oxide synthase 2, inducible, macrophage| nitric oxide synthase, inducible| Nitric oxide synthase, inducible (Fragment)| nitric oxide synthase-like protein| nitric-oxide synthase like protein| nitric oxide synthase, macrophage| Nos-2| nos2a| NOS2b1| NOSII| NOS-II| NOS type II| NOS, type II| Nsl| PANDA_000133| peptidyl-cysteine S-nitrosylase NOS2| TREES_T100020137| UY3_04969| Y1Q_030417| Y956_06496| Z169_01238| nos2

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved