Summary of NOS2
NOS2 encodes Inducible NOS (iNOS) in the immune system and cardiovascular system. It helps in immune defense against pathogens by producing nitric oxide. a free radical.
NOS2 helps neurotransmission and has antimicrobial and antitumor activities (R).
NOS2 contributes to inflammation, by enhancing the synthesis of inflammatory cytokines such as IL6 and IL8. It's also induced by inflammation.
Nitric oxide lowers blood pressure.
This gene is associated with hypertension and susceptibility to malaria.
Protein names
Recommended name:
Nanos homolog 2Short name:
NOS-2- RS1137933 (NOS2) ??
- RS11653716 (NOS2) ??
- RS2248814 (NOS2) ??
- RS2297518 (NOS2) ??
- RS3729508 (NOS2) ??
- RS4795067 (NOS2) ??
- RS8072199 (NOS2) ??
- RS8078340 (NOS2) ??
- RS944722 (NOS2) ??
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Top Gene-Substance Interactions
NOS2 Interacts with These Diseases
| Disease | Score |
Substances That Increase NOS2
| Substances | Interaction | Organism | Category |
Substances That Decrease NOS2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.
Gene Pathways:
Induction:
By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta (PubMed:7528267). Down-regulated by zinc due to inhibition of NF-kappa-B transactivation activity (PubMed:25180171). By oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112).
Enzyme Regulation:
Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity.
Cofactor:
Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
Molecular Function:
- Mrna Binding
- Zinc Ion Binding
- Arginine Binding
- Flavin Adenine Dinucleotide Binding
- Fmn Binding
- Heme Binding
- Metal Ion Binding
- Nadp Binding
- Nitric-Oxide Synthase Activity
- Protein Homodimerization Activity
- Receptor Binding
- Tetrahydrobiopterin Binding
Biological Processes:
- Cell Differentiation
- Germ-Line Stem Cell Population Maintenance
- Mrna Catabolic Process
- Multicellular Organism Development
- Negative Regulation Of Meiotic Nuclear Division
- Negative Regulation Of Translation
- Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
- Spermatogenesis
- Arginine Catabolic Process
- Cell Redox Homeostasis
- Cellular Response To Interferon-Gamma
- Cellular Response To Lipopolysaccharide
- Circadian Rhythm
- Defense Response To Bacterium
- Defense Response To Gram-Negative Bacterium
- Innate Immune Response In Mucosa
- Interleukin-6 Secretion
- Interleukin-8 Secretion
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Gene Expression
- Negative Regulation Of Protein Catabolic Process
- Nitric Oxide Biosynthetic Process
- Nitric Oxide Mediated Signal Transduction
- Peptidyl-Cysteine S-Nitrosylation
- Positive Regulation Of Guanylate Cyclase Activity
- Positive Regulation Of Killing Of Cells Of Other Organism
- Positive Regulation Of Leukocyte Mediated Cytotoxicity
- Positive Regulation Of Vasodilation
- Prostaglandin Secretion
- Regulation Of Cell Proliferation
- Regulation Of Cellular Respiration
- Regulation Of Cytokine Production Involved In Inflammatory Response
- Regulation Of Insulin Secretion
- Response To Bacterium
- Response To Hypoxia
- Superoxide Metabolic Process
Drug Bank:
- L-Arginine
- Dexamethasone
- Doxorubicin
- L-Citrulline
- Miconazole
- Triflusal