Summary of NOS2
NOS2 encodes Inducible NOS (iNOS) in the immune system and cardiovascular system. It helps in immune defense against pathogens by producing nitric oxide. a free radical.
NOS2 helps neurotransmission and has antimicrobial and antitumor activities (R).
NOS2 contributes to inflammation, by enhancing the synthesis of inflammatory cytokines such as IL6 and IL8. It's also induced by inflammation.
Nitric oxide lowers blood pressure.
This gene is associated with hypertension and susceptibility to malaria.
Protein names
Recommended name:
Nanos homolog 2Short name:
NOS-2- RS1137933 (NOS2) ??
- RS11653716 (NOS2) ??
- RS2248814 (NOS2) ??
- RS2297518 (NOS2) ??
- RS3729508 (NOS2) ??
- RS4795067 (NOS2) ??
- RS8072199 (NOS2) ??
- RS8078340 (NOS2) ??
- RS944722 (NOS2) ??
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Top Gene-Substance Interactions
NOS2 Interacts with These Diseases
| Disease | Score |
Substances That Increase NOS2
| Substances | Interaction | Organism | Category |
Substances That Decrease NOS2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.
Gene Pathways:
Induction:
By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta (PubMed:7528267). Down-regulated by zinc due to inhibition of NF-kappa-B transactivation activity (PubMed:25180171). By oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112).
Enzyme Regulation:
Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity.
Cofactor:
Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
Molecular Function:
- Mrna Binding
- Nitric-Oxide Synthase Activity
- Receptor Binding
- Zinc Ion Binding
- Fmn Binding
- Heme Binding
- Tetrahydrobiopterin Binding
- Arginine Binding
- Protein Homodimerization Activity
- Metal Ion Binding
- Flavin Adenine Dinucleotide Binding
- Nadp Binding
Biological Processes:
- Response To Hypoxia
- Positive Regulation Of Leukocyte Mediated Cytotoxicity
- Innate Immune Response In Mucosa
- Mrna Catabolic Process
- Arginine Catabolic Process
- Superoxide Metabolic Process
- Nitric Oxide Biosynthetic Process
- Nitric Oxide Mediated Signal Transduction
- Multicellular Organism Development
- Spermatogenesis
- Circadian Rhythm
- Response To Bacterium
- Negative Regulation Of Gene Expression
- Negative Regulation Of Translation
- Peptidyl-Cysteine S-Nitrosylation
- Cell Differentiation
- Germ-Line Stem Cell Population Maintenance
- Positive Regulation Of Guanylate Cyclase Activity
- Prostaglandin Secretion
- Regulation Of Cell Proliferation
- Negative Regulation Of Protein Catabolic Process
- Defense Response To Bacterium
- Regulation Of Cellular Respiration
- Cell Redox Homeostasis
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Meiotic Nuclear Division
- Positive Regulation Of Vasodilation
- Regulation Of Insulin Secretion
- Defense Response To Gram-Negative Bacterium
- Positive Regulation Of Killing Of Cells Of Other Organism
- Cellular Response To Lipopolysaccharide
- Cellular Response To Interferon-Gamma
- Interleukin-6 Secretion
- Interleukin-8 Secretion
- Regulation Of Cytokine Production Involved In Inflammatory Response
- Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
Drug Bank:
- L-Arginine
- Dexamethasone
- Doxorubicin
- L-Citrulline
- Miconazole
- Triflusal