Summary of NOS1
NOS1, also known as nNOS or Neuronal NOS, encodes a protein that is involved in regulating gene expression and neuronal communication. Mutations of this gene are associated with problems with sperm (R).
NOS1 produces nitric oxide (NO) in the brain, which shares many properties of a neurotransmitter.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities.
Nitric oxide is synthesized from L-arginine by nitric oxide synthases.
Protein names
Recommended name:
Nitric oxide synthase, brainAlternative name(s):
Constitutive NOSNC-NOS
NOS type I
Neuronal NOS
N-NOS
nNOS
Peptidyl-cysteine S-nitrosylase NOS1
bNOS
- RS1483757 (NOS1) ??
- RS2293050 (NOS1) ??
- RS2293052 (NOS1) ??
- RS2682826 (NOS1) ??
- RS3782206 (NOS1) ??
- RS3782219 (NOS1) ??
- RS3782221 (NOS1) ??
- RS478597 (NOS1) ??
- RS561712 (NOS1) ??
- RS6490121 (NOS1) ??
- RS73208120 (NOS1) ??
- RS7977109 (NOS1) ??
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Top Gene-Substance Interactions
NOS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase NOS1
| Substances | Interaction | Organism | Category |
Substances That Decrease NOS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
Gene Pathways:
Enzyme Regulation:
Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP.
Cofactor:
Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
Molecular Function:
- Rna Binding
- Translation Repressor Activity
- Zinc Ion Binding
- Arginine Binding
- Cadmium Ion Binding
- Flavin Adenine Dinucleotide Binding
- Fmn Binding
- Heme Binding
- Ion Channel Binding
- Iron Ion Binding
- Nadp Binding
- Nitric-Oxide Synthase Activity
- Scaffold Protein Binding
- Sodium Channel Regulator Activity
- Tetrahydrobiopterin Binding
Biological Processes:
- Cerebellar Neuron Development
- Epithelial Cell Migration
- Negative Regulation Of Translation
- Positive Regulation Of Nuclear-Transcribed Mrna Catabolic Process, Deadenylation-Dependent Decay
- Posttranscriptional Regulation Of Gene Expression
- Regulation Of Cell Growth
- Tissue Homeostasis
- Arginine Catabolic Process
- Cell Redox Homeostasis
- Cellular Response To Growth Factor Stimulus
- Exogenous Drug Catabolic Process
- Multicellular Organismal Response To Stress
- Myoblast Fusion
- Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Calcium Ion Transport
- Negative Regulation Of Calcium Ion Transport Into Cytosol
- Negative Regulation Of Hydrolase Activity
- Negative Regulation Of Potassium Ion Transport
- Negative Regulation Of Serotonin Uptake
- Neurotransmitter Biosynthetic Process
- Nitric Oxide Biosynthetic Process
- Nitric Oxide Mediated Signal Transduction
- Peptidyl-Cysteine S-Nitrosylation
- Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process
- Positive Regulation Of Guanylate Cyclase Activity
- Positive Regulation Of Histone Acetylation
- Positive Regulation Of Sodium Ion Transmembrane Transport
- Positive Regulation Of The Force Of Heart Contraction
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Vasodilation
- Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-Gated Calcium Channel
- Regulation Of Cardiac Conduction
- Regulation Of Cardiac Muscle Contraction
- Regulation Of Neurogenesis
- Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
- Regulation Of Sodium Ion Transport
- Response To Heat
- Response To Hypoxia
- Striated Muscle Contraction
- Aging
- Behavioral Response To Cocaine
- Cellular Response To Mechanical Stimulus
- Female Pregnancy
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Cytosolic Calcium Ion Concentration
- Negative Regulation Of Heart Contraction
- Negative Regulation Of Insulin Secretion
- Negative Regulation Of Vasoconstriction
- Positive Regulation Of Long-Term Synaptic Potentiation
- Positive Regulation Of Neuron Death
- Regulation Of Sensory Perception Of Pain
- Response To Estrogen
- Response To Ethanol
- Response To Lead Ion
- Response To Lipopolysaccharide
- Response To Nicotine
- Response To Nitric Oxide
- Response To Peptide Hormone
- Response To Vitamin E
Drug Bank:
- Flavin Adenine Dinucleotide
- Doxorubicin
- L-Citrulline