The Function of NME2
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
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Protein names
Recommended name:
Nucleoside diphosphate kinase BShort name:
NDK BAlternative name(s):
NDP kinase BC-myc purine-binding transcription factor PUF
Histidine protein kinase NDKB
nm23-H2
- RS4605213 (NME2) ??
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Top Gene-Substance Interactions
Substances That Increase NME2
| Substances | Interaction | Organism | Category |
Substances That Decrease NME2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 and isoform 3 are ubiquitously expressed.
Gene Pathways:
Molecular Function:
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Nucleoside Diphosphate Kinase Activity
- Protein Serine/Threonine Kinase Activity
- Fatty Acid Binding
- Atp Binding
- Drug Binding
- Metal Ion Binding
Biological Processes:
- Negative Regulation Of Myeloid Leukocyte Differentiation
- Purine Nucleotide Metabolic Process
- Gtp Biosynthetic Process
- Pyrimidine Nucleotide Metabolic Process
- Utp Biosynthetic Process
- Ctp Biosynthetic Process
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Cell Adhesion
- Integrin-Mediated Signaling Pathway
- Nucleoside Triphosphate Biosynthetic Process
- Positive Regulation Of Neuron Projection Development
- Nucleobase-Containing Small Molecule Interconversion
- Positive Regulation Of Camp Biosynthetic Process
- Cellular Response To Oxidative Stress
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Keratinocyte Differentiation
- Regulation Of Epidermis Development
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Protein Autophosphorylation
- Positive Regulation Of Epithelial Cell Proliferation
- Protein Oligomerization
- Response To Growth Hormone
- Cellular Response To Glucose Stimulus
- Cellular Response To Fatty Acid
- Mitophagy In Response To Mitochondrial Depolarization