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  3. NME2

NME2 (NME/NM23 nucleoside diphosphate kinase 2)

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The Function of NME2

Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

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Protein names

Recommended name:

Nucleoside diphosphate kinase B

Short name:

NDK B

Alternative name(s):

NDP kinase B
C-myc purine-binding transcription factor PUF
Histidine protein kinase NDKB
nm23-H2

NME2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4605213 (NME2) ??

Top Gene-Substance Interactions

Substances That Increase NME2

Substances Interaction Organism Category

Substances That Decrease NME2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Myc
  • Sp1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • ITF-2

Tissue specificity:

Isoform 1 and isoform 3 are ubiquitously expressed.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Purine metabolism
  • Pyrimidine metabolism

Molecular Function:

  • Atp Binding
  • Dna Binding
  • Drug Binding
  • Fatty Acid Binding
  • Metal Ion Binding
  • Nucleoside Diphosphate Kinase Activity
  • Protein Serine/Threonine Kinase Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Cell Adhesion
  • Cellular Response To Fatty Acid
  • Cellular Response To Glucose Stimulus
  • Cellular Response To Oxidative Stress
  • Ctp Biosynthetic Process
  • Gtp Biosynthetic Process
  • Integrin-Mediated Signaling Pathway
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Myeloid Leukocyte Differentiation
  • Nucleobase-Containing Small Molecule Interconversion
  • Nucleoside Triphosphate Biosynthetic Process
  • Positive Regulation Of Camp Biosynthetic Process
  • Positive Regulation Of Epithelial Cell Proliferation
  • Positive Regulation Of Keratinocyte Differentiation
  • Positive Regulation Of Neuron Projection Development
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Protein Autophosphorylation
  • Protein Oligomerization
  • Purine Nucleotide Metabolic Process
  • Pyrimidine Nucleotide Metabolic Process
  • Regulation Of Epidermis Development
  • Regulation Of Transcription, Dna-Templated
  • Response To Growth Hormone
  • Transcription, Dna-Templated
  • Utp Biosynthetic Process
  • Mitophagy In Response To Mitochondrial Depolarization

Drug Bank:

  • Lamivudine
  • Tenofovir
  • Adefovir Dipivoxil
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| nucleoside diphosphate kinase B| c-myc purine-binding transcription factor PUF| c-myc transcription factor| CNDPK| epididymis secretory sperm binding protein Li 155an| expressed in non-metastatic cells 2| expressed in non-metastatic cells 2 protein| HEL-S-155an| histidine protein kinase NDKB| N305_05693| N324_00759| N326_03644| N329_11170| N336_02195| NDK| ndk a1| ndk a2| NDKB| NDK B| ndpk-b| NDPKB| NDP kinase| NDP kinase alpha| NDP kinase B| nm23-2| nm23b| NM23-C2| nm23-h2| nm23-M2| nm23ndk| NM23-X1| nme2-a| nme2-b| non-metastatic cells 2, protein (NM23B) expressed in| non-metastatic cells 2, protein (NM23B) expressed in pseudogene| non-metastatic cells 2, protein (NM23) expressed in| nucleoside diphosphate kinase| nucleoside-diphosphate kinase 2| nucleotide diphosphate kinase B| P18| p18-12d| puf| putative nucleoside diphosphate kinase variant 1| putative nucleoside diphosphate kinase variant 2| nme2

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