The Function of NLRP6
As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism.
Protein names
Recommended name:
NACHT, LRR and PYD domains-containing protein 6Alternative name(s):
Angiotensin II/vasopressin receptorPYRIN-containing APAF1-like protein 5
- RS17655730 (NLRP6) ??
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Top Gene-Substance Interactions
Substances That Increase NLRP6
| Substances | Interaction | Organism | Category |
Substances That Decrease NLRP6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Expressed in colonic myofibroblasts (at protein level) (PubMed:21593405).
Induction:
Up-regulated by rosiglitazone, a PPARG agonist, in Caco2 and HCT116 colorectal carcinoma cells (PubMed:21088234, PubMed:23470617). Down-regulated by CRH (at protein level) (PubMed:23470617).
Molecular Function:
Biological Processes:
- Inflammatory Response
- Innate Immune Response
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Inflammatory Response To Antigenic Stimulus
- Negative Regulation Of Toll-Like Receptor Signaling Pathway
- Regulation Of Autophagy
- Regulation Of Inflammatory Response
- Regulation Of Mucus Secretion
- Response To Bacterium
- Wound Healing