The Function of NFKBIZ
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.
Protein names
Recommended name:
NF-kappa-B inhibitor zetaShort name:
INAPAlternative name(s):
I-kappa-B-zetaIkB-zeta
IkappaBzeta
IL-1 inducible nuclear ankyrin-repeat protein
Molecule possessing ankyrin repeats induced by lipopolysaccharide
- RS616597 (NFKBIZ) ??
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Top Gene-Substance Interactions
Substances That Increase NFKBIZ
| Substances | Interaction | Organism | Category |
Substances That Decrease NFKBIZ
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
Induction:
By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS).
Molecular Function:
Biological Processes:
- Inflammatory Response
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription, Dna-Templated