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  3. NFKBIZ

NFKBIZ (NFKB inhibitor zeta)

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The Function of NFKBIZ

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.

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Protein names

Recommended name:

NF-kappa-B inhibitor zeta

Short name:

INAP

Alternative name(s):

I-kappa-B-zeta
IkB-zeta
IkappaBzeta
IL-1 inducible nuclear ankyrin-repeat protein
Molecule possessing ankyrin repeats induced by lipopolysaccharide
MAIL

NFKBIZ SNPs

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  1. RS616597 (NFKBIZ) ??

Top Gene-Substance Interactions

Substances That Increase NFKBIZ

Substances Interaction Organism Category

Substances That Decrease NFKBIZ

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CREB
  • deltaCREB
  • NF-kappaB1
  • C/EBPbeta

Tissue specificity:

Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.

Induction:

By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS).

Molecular Function:

  • Transcription Cofactor Activity

Biological Processes:

  • Inflammatory Response
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_13083| AS28_00531| CB1_001107088| H920_01988| I79_013809| ikappaBzeta| I-kappa-B-zeta| IkappaB-zeta| Ikappa B-zeta variant 3| IKBZ| ikB-zeta| IL-1 inducible nuclear ankyrin-repeat protein| INAP| M91_03021| M959_00340| MAIL| MDA_GLEAN10009266| molecule associated with ankyrin repeats induced by lipopolysaccharide| molecule possessing ankyrin repeats induced by lipopolysaccharide| molecule possessing ankyrin-repeats induced by lipopolysaccharide| molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), homolog of mouse| N300_14429| N301_08369| N302_07968| N303_14140| N305_06399| N306_09851| N307_01693| N308_09711| N309_10654| N310_05316| N311_02622| N312_11761| N320_10773| N321_06646| N322_01492| N324_06041| N325_05957| N327_08829| N328_13014| N329_03695| N330_11507| N331_00695| N332_06171| N333_05166| N334_14302| N335_12005| N336_12162| N339_00237| N341_03553| NF-kappa-B inhibitor zeta| nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta| nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta| nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta isoform a-like protein| nuclear factor of kappa light polypeptide protein enhancer in B-cells inhibitor, zeta| PAL_GLEAN10024826| PANDA_005298| RGD1310834| TREES_T100020335| UY3_08734| Y1Q_019953| Y956_09463| Z169_08890| nfkbiz

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