Summary of NFKBIZ
The NFKBIZ gene encodes a protein called NFKB inhibitor zeta [R].
NFKBIZ influences how the immune system reacts to bacteria by modifying the inflammatory response to LPS. As its name suggests, it blocks NF-kB in some instances. It may also activate the production of the inflammatory cytokine IL-6 [R, R].
Variants in NFKBIZ have been linked to [R, R, R, R, R, R]:
- Lymphoma
- Multiple sclerosis
- Type 2 diabetes
- Pneumococcal disease
- Psoriatic arthritis
- Inflammatory bowel disease (IBD)
Protein names
Recommended name:
NF-kappa-B inhibitor zetaShort name:
INAPAlternative name(s):
I-kappa-B-zetaIkB-zeta
IkappaBzeta
IL-1 inducible nuclear ankyrin-repeat protein
Molecule possessing ankyrin repeats induced by lipopolysaccharide
- RS616597 (NFKBIZ) ??
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Top Gene-Substance Interactions
Substances That Increase NFKBIZ
| Substances | Interaction | Organism | Category |
Substances That Decrease NFKBIZ
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
Induction:
By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS).
Molecular Function:
Biological Processes:
- Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Inflammatory Response