Summary of NFKBIL1
The gene codes for a protein, NFKB inhibitor like 1. Function has not yet been determined [R].
The Function of NFKBIL1
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.
Protein names
Recommended name:
NF-kappa-B inhibitor-like protein 1Alternative name(s):
Inhibitor of kappa B-like proteinI-kappa-B-like protein
IkappaBL
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
- RS2230365 (NFKBIL1) ??
- RS2255798 (NFKBIL1) ??
- RS3130062 (NFKBIL1) ??
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Top Gene-Substance Interactions
NFKBIL1 Interacts with These Diseases
| Disease | Score |
Substances That Increase NFKBIL1
| Substances | Interaction | Organism | Category |
Substances That Decrease NFKBIL1
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Rheumatoid arthritisFrom UniProt: Rheumatoid arthritis (RA): An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. [MIM:180300]
From NCBI Gene: This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] From UniProt: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.
Biological Processes:
- Cellular Response To Lipopolysaccharide
- Cytoplasmic Sequestering Of Transcription Factor
- I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Negative Regulation Of Toll-Like Receptor Signaling Pathway
- Negative Regulation Of Tumor Necrosis Factor Production