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  3. NFKBIL1

NFKBIL1 (NFKB inhibitor like 1)

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Summary of NFKBIL1

The gene codes for a protein, NFKB inhibitor like 1. Function has not yet been determined [R].

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The Function of NFKBIL1

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.

Protein names

Recommended name:

NF-kappa-B inhibitor-like protein 1

Alternative name(s):

Inhibitor of kappa B-like protein
I-kappa-B-like protein
IkappaBL
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

NFKBIL1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2230365 (NFKBIL1) ??
  2. RS2255798 (NFKBIL1) ??
  3. RS3130062 (NFKBIL1) ??

Top Gene-Substance Interactions

NFKBIL1 Interacts with These Diseases

Disease Score

Substances That Increase NFKBIL1

Substances Interaction Organism Category

Substances That Decrease NFKBIL1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Rheumatoid arthritisFrom UniProt: Rheumatoid arthritis (RA): An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. [MIM:180300]

     From NCBI Gene: This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] From UniProt: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.

Biological Processes:

  • Cellular Response To Lipopolysaccharide
  • Cytoplasmic Sequestering Of Transcription Factor
  • I-Kappab Kinase/Nf-Kappab Signaling
  • Negative Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
  • Negative Regulation Of Nf-Kappab Transcription Factor Activity
  • Negative Regulation Of Toll-Like Receptor Signaling Pathway
  • Negative Regulation Of Tumor Necrosis Factor Production
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| nuclear factor of kappa light polypeptide gene enhancer in B-cel| CB1_000383014| D623_10007271| Def-7| EGK_14703| EH28_10362| enhancer in B-cells inhibitor-like 1| GW7_04770| I79_016473| ikappaBL| I-kappa-B-like protein| IKBL| inhibitor of kappa B-like protein| inhibitor of Rel family transcription factors| LST1| M91_10750| MDA_GLEAN10005612| NF-kappa-B inhibitor-like protein| NF-kappa-B inhibitor-like protein 1| NF-kappaB inhibitor-like protein 1| NF-kappa-B inhibitor-like protein 1-like protein| NFKBIL| nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1| nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1| nuclear factor of kappa light polypeptide protein enhancer in B-cells inhibitor-like 1| PAL_GLEAN10001100| PANDA_020421| putative I kappa B protein| putative inhibitor of Rel family transcription factors| TREES_T100017814| Y1Q_010490| nfkbil1

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