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  3. NFIL3

NFIL3 (Nuclear factor, interleukin 3 regulated)

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The Function of NFIL3

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death.

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Protein names

Recommended name:

Nuclear factor interleukin-3-regulated protein

Alternative name(s):

E4 promoter-binding protein 4
Interleukin-3 promoter transcriptional activator
Interleukin-3-binding protein 1
Transcriptional activator NF-IL3A

Top Gene-Substance Interactions

Substances That Increase NFIL3

Substances Interaction Organism Category

Substances That Decrease NFIL3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • C/EBPalpha
  • HNF-4alpha1
  • HNF-4alpha2
  • GATA-1
  • STAT6
  • E4BP4

Tissue specificity:

Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.

Induction:

Up-regulated by PHA or TPA.

Molecular Function:

  • Dna Binding
  • Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Cellular Response To Interleukin-4
  • Circadian Rhythm
  • Immune Response
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Gene Expression
  • Transcription From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_16610| AS27_03603| AS28_08062| AV225605| bZIP protein E4BP4| CB1_000238002| cE4BP4 protein| D623_10016869| E4 binding protein 4-1| E4BP4| E4BP4-1| E4 promoter-binding protein 4| EGK_07896| EH28_18450| embryo implantation-related NFIL3/E4BP4-like transcription factor| GW7_21657| H920_16463| I79_016054| il3bp1| interleukin-3-binding protein 1| interleukin-3 promoter transcriptional activator| M959_04685| MDA_GLEAN10004454| N300_12352| N301_13960| N302_10329| N303_07054| N305_13550| N306_05043| N307_10508| N309_07939| N310_08261| N311_05834| N312_03019| N321_12350| N322_04790| N324_01469| N325_00772| N326_11302| N327_12341| N329_10510| N330_10249| N331_11054| N332_13712| N333_00334| N334_03479| N335_12303| N336_00058| N339_08319| N340_10908| N341_02816| nf-il3a| NFIL3A| nuclear factor, interleukin 3, regulated| nuclear factor interleukin-3-regulated protein| nuclear factor interleukin-3-regulated protein-like protein| PANDA_007739| putative uncharacterized protein DDB_G0286901| putative uncharacterized protein DDB_G0293878| transcriptional activator NF-IL3A| TREES_T100017327| UY3_04172| Y1Q_013633| Y956_01844| Z169_09186| ze4bp4-1| nfil3

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