• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. NFE2L2

NFE2L2 (Nuclear factor, erythroid 2 like 2)

Loading...

Summary of NFE2L2

Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a protein (transcription factor). Nrf2 increases the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.

Substances that stimulate the Nrf2 pathway are being studied for the treatment of diseases that are caused by oxidative stress.

It responds to injury and inflammation [R].

It's better to have this gene increased most of the time.
0 users want this gene increased, 0 users want it decreased

The Function of NFE2L2

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Protein names

Recommended name:

Nuclear factor erythroid 2-related factor 2

Short name:

HEBP1

Alternative name(s):

NF-E2-related factor 2
NFE2-related factor 2
Nuclear factor, erythroid derived 2, like 2

NFE2L2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10183914 (NFE2L2) ??
  2. RS16865105 (NFE2L2) ??
  3. RS1806649 (NFE2L2) ??
  4. RS1962142 (NFE2L2) ??
  5. RS2001350 (NFE2L2) ??
  6. RS2886161 (NFE2L2) ??
  7. RS35652124 (NFE2L2) ??
  8. RS6706649 (NFE2L2) ??
  9. RS6721961 (NFE2L2) ??
  10. RS6726395 (NFE2L2) ??
  11. RS7557529 (NFE2L2) ??

Top Gene-Substance Interactions

NFE2L2 Interacts with These Diseases

Disease Score

Fixes

Top Ways to Increase Nrf2:

  • Exercise (R)
  • Calorie Restriction (R)
  • Ketosis (R)
  • LLLT (R)
  • Fish oil/DHA (R)
  • Vitamin D (R)
  • Sulforaphane/Broccoli sprouts (R) -and other Isothiocyanates from cruciferous vegetables (R)
  • Lipoic Acid
  • Butyrate (R)
  • Garlic (R)
  • Curcumin (R)

Fixes Advanced

Other Ways to Activate Nrf2:

  • PGC-1a (R)
  • Molecular Hydrogen (R),
  • Thyroid hormones (R)
  • Luteolin (R) “ luteolin is ideal because it inhibits Nrf2 in many cancer cells (R),
  • Berberine (R),
  • PQQ (R),
  • Cinnamaldehyde (R),
  • Anthocyanins (R, R2)
  • Carnitine (R),
  •  Andrographolide/Andrographis (R),
  • Black Cumin Oil (R),
  • EGCG (R),
  • Astaxanthin (R),
  • Lycopene (R),
  • Tocopherols and tocotrienols (R),
  • Quercetin (R),
  • Naringenin (R),
  • Resveratrol
  • Chlorella (R),
  • Cocoa (R),
  • Schisandra (R),
  • Licorice (R),
  • Chinese Skullcap -  Baicalin (R), Baicalein (R, R2) and Wogonin (R)
  • Citrus Flavanoids/Citrus Bioflavonoids (R),
  • Withanolide A/Ashwagandha (R),
  • Pau Darco (R),
  • Ginkgolide B (prevents suppression)/Ginkgo (R),
  • Oleanolic acid (R)
  • Apigenin (R)
  • Melatonin (R)
  • Ginger/6-Shigoal (R)
  • Pterostilbene (R),
  • Hops (R)
  • High-dose Vitamin C (R)
  • Celastrol found in Thunder God Vine Extract (R)
  • Artemisia (R)
  • Kaempferol (R),
  • Genistein (R), Soy Isoflavones (R),
  • Bilirubin (R),
  • Betanin/Beets (R),
  • Chlorogenic acid (R),
  • Carnosic acid/Rosemary (R)
  • Grapes (R)
  • Propolis (Brazilian green) (R)
  • Kiwi peel (R), Geranium (R),

Inhibitors of Nrf2: SIRT1 decreases Nrf2-related gene production since acetylation allows Nrf2 to bind to DNA better and produce antioxidant genes (R).  This is a downside of SIRT1.

Substances That Increase NFE2L2

Substances Interaction Organism Category

Substances That Decrease NFE2L2

Substances Interaction Organism Category

Advanced Summary

Read: About  NRF2  and Natural Ways to Increase It. 

Nrf2 increases the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. 

--------------------------------------------------------------------------------------

 Nrf2 is found in the highest concentrations (in descending order) in the kidney, muscle, lung, heart, liver, and brain (R). Nrf2 stimulates  NQO1 , which donates electrons and detoxifies a variety of chemicals and drugs.

 NQO1 is important for phase 2 detox.  I suspect that people sensitive to everything have less NQO1 or less of an electron supply. Nrf2 produces two of the most important rate-limiting steps in  glutathione  (GSH) production.

Glutamate-cysteine ligase, catalytic (Gclc) and glutamate-cysteine ligase, modifier (GCLM) bind together to form  glutathione .  These are produced by Nrf2.

The  glutathione S-transferase  (GST) allow  glutathione  to bind with drugs and toxins, which then allow the body to eliminate potentially harmful and toxic compounds. GSTs are produced by Nrf2 activation and represent an important route of detoxification.

Sulfiredoxin 1 (SRXN1) and Thioredoxin reductase 1 (TXNRD1) give over electrons to peroxiredoxins, proteins important in the detoxification of hydrogen peroxide and peroxynitrite.

Nrf2 stimulates Heme oxygenase-1. Heme oxygenase-1 (HMOX1, HO-1) is an enzyme that catalyzes the breakdown of heme into the antioxidant biliverdin, the anti-inflammatory agent carbon monoxide, and iron.  HO-1  defends against sepsis, hypertension, atherosclerosis, acute lung injury, kidney injury, and pain.

The UDP-glucuronosyltransferase (UGT) family catalyze the conjugation of a glucuronic acid to drugs, chemicals, and toxins, making them more water-soluble and readily excreted.  Nrf2 has been shown to induce  UGT1A1  and  UGT1A6 . Bilirubin and Tylenol are examples of substances that are glucuronidated.

My clients are more likely to have higher bilirubin and this can come from less of an ability to glucuronidation enzymes. Multidrug resistance-associated proteins (Mrps) are important membrane transporters that eject various compounds from various organs into bile or plasma, with subsequent excretion in the feces or urine, respectively. Mrps have been shown to be increased by Nrf2 and alteration in their expression can dramatically alter the pharmacokinetics and toxicity of compounds.

People with CIRS or biotoxin related issues usually have a problem excreting toxins in an efficient way and almost certainly the Nrf2 pathway will help excrete these toxins more easily. Reference.

The Negatives of Nrf2 Activation: Activation of  NRF2  may promote the development of cancerous tumors.  It can also contribute to the development of heart disease by raising cholesterol levels and cholesterol content in the liver. Having low cholesterol might be an indicator of less Nrf2 function (although there are many other pathways that lower cholesterol). Reference.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Gene Pathways:

  • Protein processing in endoplasmic reticulum

Induction:

Down-regulated by ENC1 via a proteasomal ubiquitin-independent protein catabolic process.

Molecular Function:

  • Dna Binding
  • Protein Domain Specific Binding
  • Rna Polymerase Ii Activating Transcription Factor Binding
  • Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Regulatory Region Dna Binding
  • Transcription Regulatory Region Sequence-Specific Dna Binding

Biological Processes:

  • Aging
  • Cell Redox Homeostasis
  • Cellular Response To Fluid Shear Stress
  • Cellular Response To Glucose Starvation
  • Cellular Response To Hydrogen Peroxide
  • Cellular Response To Hypoxia
  • Cellular Response To Laminar Fluid Shear Stress
  • Cellular Response To Oxidative Stress
  • Cellular Response To Tumor Necrosis Factor
  • Endoplasmic Reticulum Unfolded Protein Response
  • Inflammatory Response
  • Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
  • Negative Regulation Of Endothelial Cell Apoptotic Process
  • Negative Regulation Of Hematopoietic Stem Cell Differentiation
  • Negative Regulation Of Hydrogen Peroxide-Induced Cell Death
  • Negative Regulation Of Oxidative Stress-Induced Intrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
  • Perk-Mediated Unfolded Protein Response
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Blood Coagulation
  • Positive Regulation Of Blood Vessel Endothelial Cell Migration
  • Positive Regulation Of Er-Associated Ubiquitin-Dependent Protein Catabolic Process
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Glucose Import
  • Positive Regulation Of Glutathione Biosynthetic Process
  • Positive Regulation Of Neuron Projection Development
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Oxidative Stress
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Stress
  • Proteasomal Ubiquitin-Independent Protein Catabolic Process
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Protein Ubiquitination
  • Regulation Of Embryonic Development
  • Regulation Of Removal Of Superoxide Radicals
  • Transcription From Rna Polymerase Ii Promoter
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_15496| Anapl_04751| CB1_001176003| D623_10035008| ECH| H920_16230| HEBP1| M91_12245| MDA_GLEAN10026224| N302_06732| N320_08919| N326_06857| N327_10924| N330_00187| N331_06508| N333_12308| N334_10698| N336_10075| N339_07939| NF-E2| NF-E2R2| NF-E2-related factor 2| NFE2-related factor 2| NRF2| Nrf2/ECH| nuclear factor, erythroid 2-like 2| Nuclear factor erythroid 2-related factor 2| nuclear factor erythroid 2 related factor 2-like protein| nuclear factor erythroid 2-related factor 2-like protein| nuclear factor (erythroid-derived 2)-like 2| nuclear factor erythroid-derived 2-like 2| nuclear factor, erythroid derived 2, like 2| PAL_GLEAN10026004| PANDA_016477| UY3_07731| Y1Q_004836| nfe2l2

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved