The Function of NFATC3
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.
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Protein names
Recommended name:
Nuclear factor of activated T-cells, cytoplasmic 3Alternative name(s):
NF-ATc3NFATc3
NFATx
T-cell transcription factor NFAT4
NF-AT4
- RS8044995 (NFATC3) ??
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Top Gene-Substance Interactions
Substances That Increase NFATC3
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Substances That Decrease NFATC3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
Biological Processes:
- Fc-Epsilon Receptor Signaling Pathway
- Inflammatory Response
- Negative Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription From Rna Polymerase Ii Promoter