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  3. NF1

NF1 (Neurofibromin 1)

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The Function of NF1

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

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Protein names

Recommended name:

Neurofibromin

Alternative name(s):

Neurofibromatosis-related protein NF-1

NF1 SNPs

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  1. RS17826255 (NF1) ??

Top Gene-Substance Interactions

NF1 Interacts with These Diseases

Disease Score

Substances That Increase NF1

Substances Interaction Organism Category

Substances That Decrease NF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-1A
  • GR
  • GR-alpha
  • p53
  • HNF-1
  • C/EBPalpha
  • IRF-2
  • AML1a
  • NF-1

Tissue specificity:

Detected in brain, peripheral nerve, lung, colon and muscle.

Gene Pathways:

  • MAPK signaling pathway

Caution:

Was originally thought to be associated with LEOPARD (LS), an autosomal dominant syndrome.

Molecular Function:

  • Gtpase Activator Activity
  • Phosphatidylcholine Binding
  • Phosphatidylethanolamine Binding

Biological Processes:

  • Actin Cytoskeleton Organization
  • Adrenal Gland Development
  • Amygdala Development
  • Artery Morphogenesis
  • Brain Development
  • Camera-Type Eye Morphogenesis
  • Cell Communication
  • Cellular Response To Heat
  • Cerebral Cortex Development
  • Cognition
  • Collagen Fibril Organization
  • Extracellular Matrix Organization
  • Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Forebrain Astrocyte Development
  • Forebrain Morphogenesis
  • Gamma-Aminobutyric Acid Secretion, Neurotransmission
  • Glutamate Secretion, Neurotransmission
  • Heart Development
  • Liver Development
  • Mapk Cascade
  • Metanephros Development
  • Myelination In Peripheral Nervous System
  • Negative Regulation Of Angiogenesis
  • Negative Regulation Of Astrocyte Differentiation
  • Negative Regulation Of Cell-Matrix Adhesion
  • Negative Regulation Of Cell Migration
  • Negative Regulation Of Endothelial Cell Proliferation
  • Negative Regulation Of Fibroblast Proliferation
  • Negative Regulation Of Mapk Cascade
  • Negative Regulation Of Map Kinase Activity
  • Negative Regulation Of Neuroblast Proliferation
  • Negative Regulation Of Neurotransmitter Secretion
  • Negative Regulation Of Oligodendrocyte Differentiation
  • Negative Regulation Of Osteoclast Differentiation
  • Negative Regulation Of Protein Kinase Activity
  • Negative Regulation Of Rac Protein Signal Transduction
  • Negative Regulation Of Ras Protein Signal Transduction
  • Negative Regulation Of Transcription Factor Import Into Nucleus
  • Neural Tube Development
  • Observational Learning
  • Osteoblast Differentiation
  • Peripheral Nervous System Development
  • Phosphatidylinositol 3-Kinase Signaling
  • Pigmentation
  • Positive Regulation Of Adenylate Cyclase Activity
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
  • Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Positive Regulation Of Gtpase Activity
  • Positive Regulation Of Neuron Apoptotic Process
  • Ras Protein Signal Transduction
  • Regulation Of Angiogenesis
  • Regulation Of Blood Vessel Endothelial Cell Migration
  • Regulation Of Bone Resorption
  • Regulation Of Cell-Matrix Adhesion
  • Regulation Of Gene Expression
  • Regulation Of Glial Cell Differentiation
  • Regulation Of Gtpase Activity
  • Regulation Of Long-Term Neuronal Synaptic Plasticity
  • Regulation Of Long-Term Synaptic Potentiation
  • Regulation Of Synaptic Transmission, Gabaergic
  • Response To Hypoxia
  • Schwann Cell Development
  • Skeletal Muscle Tissue Development
  • Smooth Muscle Tissue Development
  • Spinal Cord Development
  • Sympathetic Nervous System Development
  • Visual Learning
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_13548| AS28_09414| CB1_000765057| CG8318 gene product from transcript CG8318-RD| CG8318-PB| CG8318-PC| CG8318-PD| CG8318-PE| CG8318-PF| D623_10019604| Dmel_CG8318| dNF1| Dsk9| H920_13101| M91_10443| M959_13445| MDA_GLEAN10014419| Mhdadsk9| N300_14077| N301_08121| N303_14604| N305_07206| N306_15606| N307_14197| N308_14349| N310_08625| N311_06404| N312_04643| N320_02460| N321_13563| N322_07486| N324_03774| N325_12199| N326_08937| N327_04427| N328_09769| N329_08666| N330_04745| N331_02981| N333_09319| N334_01251| N335_12394| N336_01650| N340_02598| neurofibramatosis-1| neurofibromatosis 1| Neurofibromatosis-1| neurofibromatosis factor 1| neurofibromatosis protein type 1| neurofibromatosis-related protein NF-1| Neurofibromatosis type 1| neurofibromin| neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)| Neurofibromin-like protein| neurofibromin type 1| Nf-1| Nf1-PB| Nf1-PC| Nf1-PD| Nf1-PE| Nf1-PF| NFNS| PAL_GLEAN10019907| PANDA_000138| UY3_04972| VRNF| WSS| Y1Q_016136| Y956_06499| nf1

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