The Function of NF1
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
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Protein names
Recommended name:
NeurofibrominAlternative name(s):
Neurofibromatosis-related protein NF-1- RS17826255 (NF1) ??
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Top Gene-Substance Interactions
NF1 Interacts with These Diseases
| Disease | Score |
Substances That Increase NF1
| Substances | Interaction | Organism | Category |
Substances That Decrease NF1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in brain, peripheral nerve, lung, colon and muscle.
Gene Pathways:
Caution:
Was originally thought to be associated with LEOPARD (LS), an autosomal dominant syndrome.
Molecular Function:
Biological Processes:
- Mapk Cascade
- Osteoblast Differentiation
- Metanephros Development
- Response To Hypoxia
- Liver Development
- Negative Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Endothelial Cell Proliferation
- Regulation Of Cell-Matrix Adhesion
- Negative Regulation Of Cell-Matrix Adhesion
- Negative Regulation Of Protein Kinase Activity
- Cell Communication
- Ras Protein Signal Transduction
- Negative Regulation Of Neuroblast Proliferation
- Brain Development
- Peripheral Nervous System Development
- Heart Development
- Skeletal Muscle Tissue Development
- Visual Learning
- Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Regulation Of Gene Expression
- Schwann Cell Development
- Phosphatidylinositol 3-Kinase Signaling
- Negative Regulation Of Angiogenesis
- Spinal Cord Development
- Amygdala Development
- Forebrain Astrocyte Development
- Neural Tube Development
- Cerebral Cortex Development
- Myelination In Peripheral Nervous System
- Actin Cytoskeleton Organization
- Extracellular Matrix Organization
- Collagen Fibril Organization
- Adrenal Gland Development
- Negative Regulation Of Cell Migration
- Regulation Of Synaptic Transmission, Gabaergic
- Cellular Response To Heat
- Negative Regulation Of Rac Protein Signal Transduction
- Wound Healing
- Negative Regulation Of Transcription Factor Import Into Nucleus
- Positive Regulation Of Apoptotic Process
- Regulation Of Gtpase Activity
- Negative Regulation Of Map Kinase Activity
- Negative Regulation Of Mapk Cascade
- Pigmentation
- Positive Regulation Of Neuron Apoptotic Process
- Regulation Of Blood Vessel Endothelial Cell Migration
- Positive Regulation Of Gtpase Activity
- Regulation Of Bone Resorption
- Negative Regulation Of Osteoclast Differentiation
- Regulation Of Glial Cell Differentiation
- Positive Regulation Of Adenylate Cyclase Activity
- Regulation Of Angiogenesis
- Negative Regulation Of Ras Protein Signal Transduction
- Negative Regulation Of Neurotransmitter Secretion
- Negative Regulation Of Fibroblast Proliferation
- Regulation Of Long-Term Neuronal Synaptic Plasticity
- Sympathetic Nervous System Development
- Camera-Type Eye Morphogenesis
- Negative Regulation Of Astrocyte Differentiation
- Negative Regulation Of Oligodendrocyte Differentiation
- Smooth Muscle Tissue Development
- Artery Morphogenesis
- Forebrain Morphogenesis
- Cognition
- Gamma-Aminobutyric Acid Secretion, Neurotransmission
- Glutamate Secretion, Neurotransmission
- Observational Learning
- Regulation Of Long-Term Synaptic Potentiation
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand