The Function of NEK6
Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.
Protein names
Recommended name:
Serine/threonine-protein kinase Nek6Alternative name(s):
Never in mitosis A-related kinase 6NimA-related protein kinase 6
Protein kinase SID6-1512
- RS10760321 (NEK6) ??
- RS111873027 (NEK6) ??
- RS2807580 (NEK6) ??
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Top Gene-Substance Interactions
Substances That Increase NEK6
| Substances | Interaction | Organism | Category |
Substances That Decrease NEK6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous, with highest expression in heart and skeletal muscle. Up-regulated in a variety of malignant cancers, such as breast, colon, lung, and gastric cancers.
Induction:
Up-regulated during the M phase of cell cycle progression. Down-regulated in both replicative and premature senescence of cancer cells.
Enzyme Regulation:
Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108.
Molecular Function:
- Magnesium Ion Binding
- Protein Serine/Threonine Kinase Activity
- Signal Transducer Activity
- Atp Binding
- Kinesin Binding
- Protein Kinase Binding
Biological Processes:
- Cytokinesis
- Protein Phosphorylation
- Apoptotic Process
- Chromosome Segregation
- Mitotic Nuclear Division
- Mitotic Nuclear Envelope Disassembly
- Regulation Of Mitotic Cell Cycle
- Peptidyl-Serine Phosphorylation
- Regulation Of Mitotic Metaphase/Anaphase Transition
- G2 Dna Damage Checkpoint
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Protein Autophosphorylation
- Spindle Assembly
- Regulation Of Cellular Senescence