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  3. NEK6

NEK6 (NIMA related kinase 6)

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The Function of NEK6

Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.

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Protein names

Recommended name:

Serine/threonine-protein kinase Nek6

Alternative name(s):

Never in mitosis A-related kinase 6
NimA-related protein kinase 6
Protein kinase SID6-1512

NEK6 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10760321 (NEK6) ??
  2. RS111873027 (NEK6) ??
  3. RS2807580 (NEK6) ??

Top Gene-Substance Interactions

Substances That Increase NEK6

Substances Interaction Organism Category

Substances That Decrease NEK6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AhR
  • MEF-2A
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Ubiquitous, with highest expression in heart and skeletal muscle. Up-regulated in a variety of malignant cancers, such as breast, colon, lung, and gastric cancers.

Induction:

Up-regulated during the M phase of cell cycle progression. Down-regulated in both replicative and premature senescence of cancer cells.

Enzyme Regulation:

Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108.

Molecular Function:

  • Atp Binding
  • Kinesin Binding
  • Magnesium Ion Binding
  • Protein Kinase Binding
  • Protein Serine/Threonine Kinase Activity
  • Signal Transducer Activity

Biological Processes:

  • Apoptotic Process
  • Chromosome Segregation
  • Cytokinesis
  • G2 Dna Damage Checkpoint
  • Mitotic Nuclear Division
  • Mitotic Nuclear Envelope Disassembly
  • Peptidyl-Serine Phosphorylation
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Protein Autophosphorylation
  • Protein Phosphorylation
  • Regulation Of Cellular Senescence
  • Regulation Of Mitotic Cell Cycle
  • Regulation Of Mitotic Metaphase/Anaphase Transition
  • Spindle Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13057| Anapl_08030| AS27_13690| AS28_05549| H920_19158| M91_20637| M959_09300| MDA_GLEAN10019362| N300_09355| N301_12519| N302_13027| N303_06242| N305_12578| N307_04893| N309_02742| N310_09375| N311_03295| N312_01765| N320_03467| N321_05820| N322_12337| N324_12624| N326_10264| N327_08826| N328_10287| N329_08927| N331_05472| N333_01626| N339_05659| N340_12183| N341_06096| nek7| never in mitosis A-related kinase 6| NIMA (never in mitosis gene a)-related expressed kinase 6| NIMA (never in mitosis gene a)-related kinase 6| NIMA (never in mitosis gene a)-related kinase 7| NIMA-related expressed kinase 6| NIMA-related kinase 6| nimA-related protein kinase 6| PAL_GLEAN10012411| PANDA_008724| protein kinase SID6-1512| putative serine-threonine protein kinase| Serine/threonine-protein kinase Nek6| SID6-1512| TREES_T100009399| Y1Q_015143| Y956_02184| Z169_04375| zC167P9.4| nek6

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