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  3. NEFM

NEFM (Neurofilament medium)

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Summary of NEFM

The gene codes for a protein, neurofilament, medium polypeptide. It is used as a biomarker of damage in neurons [R].

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The Function of NEFM

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

Protein names

Recommended name:

Neurofilament medium polypeptide

Short name:

NF-M

Alternative name(s):

160 kDa neurofilament protein
Neurofilament 3
Neurofilament triplet M protein

NEFM SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1457266 (NEFM) ??

Top Gene-Substance Interactions

NEFM Interacts with These Diseases

Disease Score

Substances That Increase NEFM

Substances Interaction Organism Category

Substances That Decrease NEFM

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pbx1a
  • MEF-2A
  • MRF-2
  • GCNF

Gene Pathways:

  • Amyotrophic lateral sclerosis (ALS)

Molecular Function:

  • Microtubule Binding
  • Structural Constituent Of Cytoskeleton

Biological Processes:

  • Axon Development
  • Neurofilament Bundle Assembly
  • Mitophagy In Response To Mitochondrial Depolarization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 160 kDa neurofilament protein| AS27_03196| CB1_002524004| H920_00503| M959_08943| major neuronal intermediate filament subunit| medium neurofilament subunit| N300_09485| N301_09500| N303_05470| N305_08825| N306_07564| N307_15289| N308_01100| N309_05096| N312_04243| N320_08744| N322_07855| N325_02346| N326_08376| N327_00890| N328_09965| N329_12835| N334_12277| N335_11512| N336_04758| N341_10582| NEF3| nef-m| nefm-a| nefm-b| Neurofilament 3| neurofilament 3 (150kDa medium)| neurofilament-3 (150 kD medium)| neurofilament 3, medium| neurofilament-M| Neurofilament medium polypeptide| neurofilament, medium polypeptide 150kDa| neurofilament medium protein| neurofilament medium tail domain| neurofilament medium tail domain protein| neurofilament M subunit| neurofilament protein M| Neurofilament protein, middle polypeptide| neurofilament triplet M protein| NF160| NF165| nf-m| NFM| NF-M c-terminus| NF-M protein| PAL_GLEAN10012313| PANDA_002374| TREES_T100010792| UY3_12369| Y1Q_005099| Z169_05141| nefm

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