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  3. NEFL

NEFL (Neurofilament light)

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The Function of NEFL

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

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Protein names

Recommended name:

Neurofilament light polypeptide

Short name:

NF-L

Alternative name(s):

68 kDa neurofilament protein
Neurofilament triplet L protein

NEFL SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6557786 (NEFL) ??

Top Gene-Substance Interactions

NEFL Interacts with These Diseases

Disease Score

Substances That Increase NEFL

Substances Interaction Organism Category

Substances That Decrease NEFL

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta

Gene Pathways:

  • Amyotrophic lateral sclerosis (ALS)
  • Neuronal System

Molecular Function:

  • Identical Protein Binding
  • Protein Binding, Bridging
  • Protein C-Terminus Binding
  • Ras Guanyl-Nucleotide Exchange Factor Activity
  • Structural Constituent Of Cytoskeleton

Biological Processes:

  • Anterograde Axonal Transport
  • Axonal Transport Of Mitochondrion
  • Cerebral Cortex Development
  • Hippocampus Development
  • Intermediate Filament Organization
  • Intermediate Filament Polymerization Or Depolymerization
  • Locomotion
  • Mapk Cascade
  • Microtubule Cytoskeleton Organization
  • Negative Regulation Of Neuron Apoptotic Process
  • Neurofilament Bundle Assembly
  • Neuromuscular Process Controlling Balance
  • Neuron Projection Morphogenesis
  • Peripheral Nervous System Axon Regeneration
  • Positive Regulation Of Axonogenesis
  • Protein Polymerization
  • Regulation Of Axon Diameter
  • Response To Acrylamide
  • Response To Corticosterone
  • Response To Peptide Hormone
  • Response To Sodium Arsenite
  • Response To Toxic Substance
  • Retrograde Axonal Transport
  • Spinal Cord Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 68kDa neurofilament| 68 kDa neurofilament protein| A306_14008| AS27_03195| CB1_002524005| CMT1F| cmt2e| D623_10013544| EGK_21229| GW7_07636| H920_00502| I79_001527| light molecular weight neurofilament protein| Low molecular weight neuronal intermediate filament| M959_08944| MDA_GLEAN10008716| micro glutamic acid-rich protein| N308_01101| N309_05095| N320_05775| N321_10414| neurofilament-L| Neurofilament light polypeptide| neurofilament, light polypeptide 68kDa| neurofilament protein L| neurofilament protein, light chain| neurofilament subunit NF-L| Neurofilament triplet L protein| nf68| nf-l| NFL| PAL_GLEAN10012314| PANDA_002373| PPP1R110| protein phosphatase 1, regulatory subunit 110| TREES_T100010829| UY3_12370| XNF-L| XNIF| Y1Q_005100| nefl

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