The Function of NEFL
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
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Protein names
Recommended name:
Neurofilament light polypeptideShort name:
NF-LAlternative name(s):
68 kDa neurofilament proteinNeurofilament triplet L protein
- RS6557786 (NEFL) ??
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Top Gene-Substance Interactions
NEFL Interacts with These Diseases
| Disease | Score |
Substances That Increase NEFL
| Substances | Interaction | Organism | Category |
Substances That Decrease NEFL
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Structural Constituent Of Cytoskeleton
- Protein C-Terminus Binding
- Protein Binding, Bridging
- Identical Protein Binding
Biological Processes:
- Mapk Cascade
- Microtubule Cytoskeleton Organization
- Anterograde Axonal Transport
- Retrograde Axonal Transport
- Response To Toxic Substance
- Peripheral Nervous System Axon Regeneration
- Axonal Transport Of Mitochondrion
- Spinal Cord Development
- Hippocampus Development
- Cerebral Cortex Development
- Regulation Of Axon Diameter
- Neurofilament Bundle Assembly
- Locomotion
- Response To Peptide Hormone
- Negative Regulation Of Neuron Apoptotic Process
- Intermediate Filament Polymerization Or Depolymerization
- Intermediate Filament Organization
- Neuron Projection Morphogenesis
- Positive Regulation Of Axonogenesis
- Neuromuscular Process Controlling Balance
- Protein Polymerization
- Response To Corticosterone
- Response To Sodium Arsenite
- Response To Acrylamide