The Function of NDUFS3
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Protein names
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialAlternative name(s):
Complex I-30kDCI-30kD
NADH-ubiquinone oxidoreductase 30 kDa subunit
Top Gene-Substance Interactions
NDUFS3 Interacts with These Diseases
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Substances That Increase NDUFS3
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Substances That Decrease NDUFS3
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Advanced Summary
Covered on Genetics Home Reference: Leigh syndromeFrom NCBI Gene: Leigh syndromeMitochondrial complex I deficiency
From NCBI Gene: This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009] From UniProt: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Mitochondrial Electron Transport, Nadh To Ubiquinone
- Substantia Nigra Development
- Negative Regulation Of Cell Growth
- Mitochondrial Respiratory Chain Complex I Assembly
- Reactive Oxygen Species Metabolic Process
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway