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  3. NDUFS3

NDUFS3 (NADH:ubiquinone oxidoreductase core subunit S3)

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The Function of NDUFS3

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

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Protein names

Recommended name:

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Alternative name(s):

Complex I-30kD
CI-30kD
NADH-ubiquinone oxidoreductase 30 kDa subunit

Top Gene-Substance Interactions

NDUFS3 Interacts with These Diseases

Disease Score

Substances That Increase NDUFS3

Substances Interaction Organism Category

Substances That Decrease NDUFS3

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: Leigh syndromeFrom NCBI Gene: Leigh syndromeMitochondrial complex I deficiency

     From NCBI Gene: This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009] From UniProt: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • AP-1
  • c-Jun
  • C/EBPbeta
  • C/EBPalpha
  • MEF-2A
  • c-Fos
  • LCR-F1

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Alzheimer's disease
  • Huntington's disease
  • Oxidative phosphorylation
  • Parkinson's disease

Molecular Function:

  • Electron Carrier Activity
  • Nadh Dehydrogenase (Ubiquinone) Activity
  • Nadh Dehydrogenase Activity

Biological Processes:

  • Mitochondrial Electron Transport, Nadh To Ubiquinone
  • Mitochondrial Respiratory Chain Complex I Assembly
  • Negative Regulation Of Cell Growth
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
  • Reactive Oxygen Species Metabolic Process
  • Substantia Nigra Development

Drug Bank:

  • Doxorubicin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07888| AS27_02258| AS28_01287| CB1_001330019| CI-30| CI-30kD| complex I-30kD| complex I 30kDa subunit| EGK_06287| GW7_11265| H920_18691| KBTBD4| kelch repeat and BTB domain-containing protein 4| M91_11672| M959_11646| MDA_GLEAN10019079| mitochondrial complex I subunit NDUFS3| mitochondrial NADH dehydrogenase (ubiquinone) iron-sulfur protein 3| N300_12565| N301_00962| N302_01545| N303_08181| N305_10673| N306_08016| N307_13474| N308_14703| N309_11804| N310_03052| N312_08445| N320_10433| N321_03288| N322_13339| N324_08528| N325_12405| N326_00343| N327_07446| N328_02947| N329_06888| N330_00203| N332_04027| N333_12642| N334_05730| N335_11469| N336_06356| N339_01634| N340_14637| N341_05134| NADH dehydrogenase iron-sulfur protein 3, mitochondrial| NADH dehydrogenase-ubiquinone 30 kDa subunit| NADH dehydrogenase (ubiquinone) Fe-S protein 3| NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coen| NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)| NADH dehydrogenase (ubiquinone) Fe-S protein 3 (NADH-coenzyme Q reductase)| NADH dehydrogenase (ubiquinone) Fe-S protein 3, (NADH-coenzyme Q reductase)| NADH dehydrogenase [ubiquinone] iron-sulfur protein 3| NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial| NADH dehydrogenase (ubiquinone) iron-sulfur protein 3, mitochondrial-like protein| NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like protein| NADH-ubiquinone oxidoreductase 30 kDa subunit| NDUS3| OXPHOS complex I 30 kDa subunit| PAL_GLEAN10018146| PANDA_010603| TREES_T100014336| UY3_01793| Y1Q_019792| Y956_16687| Z169_07946| ndufs3

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