The Function of NDEL1
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.
Protein names
Recommended name:
Nuclear distribution protein nudE-like 1Alternative name(s):
Protein NudelMitosin-associated protein 1
- RS1391768 (NDEL1) ??
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Top Gene-Substance Interactions
Substances That Increase NDEL1
| Substances | Interaction | Organism | Category |
Substances That Decrease NDEL1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Developmental stage:
Expression peaks in mitosis.
Caution:
Was originally thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function.
Molecular Function:
Biological Processes:
- Activation Of Gtpase Activity
- Central Nervous System Neuron Axonogenesis
- Centrosome Localization
- Cerebral Cortex Radially Oriented Cell Migration
- Chromosome Segregation
- Establishment Of Chromosome Localization
- Establishment Of Mitotic Spindle Orientation
- Inner Cell Mass Cell Proliferation
- Microtubule Nucleation
- Mitotic Centrosome Separation
- Neurofilament Cytoskeleton Organization
- Neuron Migration
- Neuron Projection Extension
- Nuclear Envelope Disassembly
- Positive Regulation Of Axon Extension
- Positive Regulation Of Axon Regeneration
- Positive Regulation Of Gtpase Activity
- Regulation Of Intracellular Protein Transport
- Regulation Of Microtubule Motor Activity
- Regulation Of Neuron Projection Development
- Retrograde Axonal Transport
- Sister Chromatid Cohesion
- Vesicle Transport Along Microtubule