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  3. NCOA6

NCOA6 (Nuclear receptor coactivator 6)

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Summary of NCOA6

The gene codes for a protein, nuclear receptor coactivator 6. It interacts to activate hormones [R].

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The Function of NCOA6

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Protein names

Recommended name:

Nuclear receptor coactivator 6

Short name:

PRIP

Alternative name(s):

Activating signal cointegrator 2
ASC-2
Amplified in breast cancer protein 3
Cancer-amplified transcriptional coactivator ASC-2
Nuclear receptor coactivator RAP250
NRC RAP250
Nuclear receptor-activating protein, 250 kDa
Peroxisome proliferator-activated receptor-interacting protein
PPAR-interacting protein
Thyroid hormone receptor-binding protein

NCOA6 SNPs

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  1. RS4911442 (NCOA6) ??

Top Gene-Substance Interactions

Substances That Increase NCOA6

Substances Interaction Organism Category

Substances That Decrease NCOA6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • AP-1
  • c-Jun
  • NF-kappaB1
  • Sp1
  • c-Fos
  • STAT2
  • GATA-3

Tissue specificity:

Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.

Gene Pathways:

  • Metabolism

Molecular Function:

  • Chromatin Binding
  • Enzyme Binding
  • Estrogen Receptor Binding
  • Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
  • Retinoid X Receptor Binding
  • Thyroid Hormone Receptor Binding
  • Transcription Coactivator Activity

Biological Processes:

  • Brain Development
  • Cellular Lipid Metabolic Process
  • Cellular Response To Dna Damage Stimulus
  • Dna Recombination
  • Dna Repair
  • Dna Replication
  • Dna-Templated Transcription, Initiation
  • Glucocorticoid Receptor Signaling Pathway
  • Heart Development
  • Intracellular Estrogen Receptor Signaling Pathway
  • Myeloid Cell Differentiation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Hormone
  • Transcription Initiation From Rna Polymerase Ii Promoter
  • Ovarian Follicle Development
  • Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11959| activating signal cointegrator 2| activating signal cointegrator-2| aib3| amplified in breast cancer-3 protein| amplified in breast cancer protein 3| antp| ASC2| ASC-2| cancer-amplified transcriptional coactivator ASC-2| CB1_001108013| CG14023 gene product from transcript CG14023-RD| CG14023-PC| CG14023-PD| CG14023-PF| D623_10023707| Dmel_CG14023| dNCOA6| gb:dq017635| hox1.1| hoxa7| I79_007501| M91_20163| MDA_GLEAN10022763| Mediator of RNA polymerase II transcription subunit 15| N301_05407| N302_14124| N303_12473| N308_06379| N312_03074| N320_06575| N322_05085| N324_08666| N325_05462| N326_10738| N327_11546| N328_07899| N330_04846| N336_05366| N340_13206| Ncoa6-PC| Ncoa6-PD| Ncoa6-PF| Ncoa7| nrc| NRC RAP250| nuclear receptor-activating protein 250| nuclear receptor-activating protein, 250 kDa| nuclear receptor coactivator 6-like protein| nuclear receptor coactivator RAP250| PAL_GLEAN10024254| PANDA_004518| peroxisome proliferator-activated receptor interacting protein| peroxisome proliferator-activated receptor-interacting protein| peroxisome proliferator-activated receptor interacting protein,PRIP| PPAR-interacting protein| PPAR interacting protein PRIP| PRIP| RAP250| thyroid hormone receptor binding protein| Trbp| TREES_T100008603| UY3_04555| Y1Q_020981| Y956_05669| ncoa6

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