Summary of NCOA6
The gene codes for a protein, nuclear receptor coactivator 6. It interacts to activate hormones [R].
The Function of NCOA6
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Protein names
Recommended name:
Nuclear receptor coactivator 6Short name:
PRIPAlternative name(s):
Activating signal cointegrator 2ASC-2
Amplified in breast cancer protein 3
Cancer-amplified transcriptional coactivator ASC-2
Nuclear receptor coactivator RAP250
NRC RAP250
Nuclear receptor-activating protein, 250 kDa
Peroxisome proliferator-activated receptor-interacting protein
PPAR-interacting protein
Thyroid hormone receptor-binding protein
- RS4911442 (NCOA6) ??
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Top Gene-Substance Interactions
Substances That Increase NCOA6
| Substances | Interaction | Organism | Category |
Substances That Decrease NCOA6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.
Gene Pathways:
Molecular Function:
- Chromatin Binding
- Transcription Coactivator Activity
- Enzyme Binding
- Estrogen Receptor Binding
- Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
- Retinoid X Receptor Binding
- Thyroid Hormone Receptor Binding
Biological Processes:
- Ovarian Follicle Development
- Dna Replication
- Dna Repair
- Dna Recombination
- Dna-Templated Transcription, Initiation
- Transcription Initiation From Rna Polymerase Ii Promoter
- Cellular Response To Dna Damage Stimulus
- Brain Development
- Heart Development
- Response To Hormone
- Myeloid Cell Differentiation
- Intracellular Estrogen Receptor Signaling Pathway
- Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Glucocorticoid Receptor Signaling Pathway
- Cellular Lipid Metabolic Process
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter