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  3. NCOA3

NCOA3 (Nuclear receptor coactivator 3)

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The Function of NCOA3

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

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Protein names

Recommended name:

Nuclear receptor coactivator 3

Short name:

ACTR

Alternative name(s):

NCoA-3
Amplified in breast cancer 1 protein
AIB-1
CBP-interacting protein
pCIP
Class E basic helix-loop-helix protein 42
bHLHe42
Receptor-associated coactivator 3
RAC-3
Steroid receptor coactivator protein 3
SRC-3
Thyroid hormone receptor activator molecule 1
TRAM-1

NCOA3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2230782 (NCOA3) ??
  2. RS6094710 (NCOA3) ??
  3. RS6094752 (NCOA3) ??
  4. RS6125048 (NCOA3) ??

Top Gene-Substance Interactions

NCOA3 Interacts with These Diseases

Disease Score

Substances That Increase NCOA3

Substances Interaction Organism Category

Substances That Decrease NCOA3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • PPAR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • Sp1
  • IRF-1

Tissue specificity:

Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

Enzyme Regulation:

Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.

Molecular Function:

  • Androgen Receptor Binding
  • Histone Acetyltransferase Activity
  • Ligand-Dependent Nuclear Receptor Binding
  • Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
  • Nuclear Hormone Receptor Binding
  • Protein N-Terminus Binding
  • Thyroid Hormone Receptor Binding
  • Transcription Coactivator Activity

Biological Processes:

  • Androgen Receptor Signaling Pathway
  • Cellular Response To Estradiol Stimulus
  • Intracellular Receptor Signaling Pathway
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Keratinocyte Differentiation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Receptor Transactivation
  • Regulation Of Rna Biosynthetic Process
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| bHLHe42| src-1| A306_00240| actr| aib1| AIB-1| amplified in breast cancer 1 protein| amplified in breast cancer-1 protein homolog| CAGH16| CB1_001010029| CBP-interacting protein| class E basic helix-loop-helix protein 42| CTG26| D623_10013730| GW7_07339| H920_06200| I79_006792| kat13b| N301_06916| N306_01658| N309_05511| N320_04587| N321_07443| N333_11276| NCOA2| NCoA-3| nuclear receptor coactivator 2| PAL_GLEAN10024440| PANDA_016743| p/Cip| pCIP| RAC3| RAC-3| receptor-associated coactivator 3| src-3| Src3| steroid receptor coactivator 3| steroid receptor coactivator protein 3| thyroid hormone receptor activator molecule 1| tnrc14| tnrc16| Tram1| Tram-1| TREES_T100021010| UY3_06977| xSRC-3| Y1Q_029262| ncoa3

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