The Function of NCOA3
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Protein names
Recommended name:
Nuclear receptor coactivator 3Short name:
ACTRAlternative name(s):
NCoA-3Amplified in breast cancer 1 protein
AIB-1
CBP-interacting protein
pCIP
Class E basic helix-loop-helix protein 42
bHLHe42
Receptor-associated coactivator 3
RAC-3
Steroid receptor coactivator protein 3
SRC-3
Thyroid hormone receptor activator molecule 1
TRAM-1
- RS2230782 (NCOA3) ??
- RS6094710 (NCOA3) ??
- RS6094752 (NCOA3) ??
- RS6125048 (NCOA3) ??
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Top Gene-Substance Interactions
NCOA3 Interacts with These Diseases
| Disease | Score |
Substances That Increase NCOA3
| Substances | Interaction | Organism | Category |
Substances That Decrease NCOA3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
Enzyme Regulation:
Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.
Molecular Function:
- Androgen Receptor Binding
- Histone Acetyltransferase Activity
- Ligand-Dependent Nuclear Receptor Binding
- Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
- Nuclear Hormone Receptor Binding
- Protein N-Terminus Binding
- Thyroid Hormone Receptor Binding
- Transcription Coactivator Activity
Biological Processes:
- Androgen Receptor Signaling Pathway
- Cellular Response To Estradiol Stimulus
- Intracellular Receptor Signaling Pathway
- Positive Regulation Of Gene Expression
- Positive Regulation Of Keratinocyte Differentiation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Receptor Transactivation
- Regulation Of Rna Biosynthetic Process
- Transcription, Dna-Templated