The Function of NCOA1
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Protein names
Recommended name:
Nuclear receptor coactivator 1Short name:
SRC-1Alternative name(s):
NCoA-1Class E basic helix-loop-helix protein 74
bHLHe74
Protein Hin-2
RIP160
Renal carcinoma antigen NY-REN-52
Steroid receptor coactivator 1
- RS2165738 (NCOA1) ??
- RS79480871 (NCOA1) ??
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Top Gene-Substance Interactions
NCOA1 Interacts with These Diseases
| Disease | Score |
Substances That Increase NCOA1
| Substances | Interaction | Organism | Category |
Substances That Decrease NCOA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed.
Gene Pathways:
Molecular Function:
- Rna Polymerase Ii Regulatory Region Dna Binding
- Rna Polymerase Ii Transcription Coactivator Activity
- Chromatin Binding
- Transcription Coactivator Activity
- Histone Acetyltransferase Activity
- Ligand-Dependent Nuclear Receptor Binding
- Enzyme Binding
- Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
- Nuclear Hormone Receptor Binding
- Protein N-Terminus Binding
- Androgen Receptor Binding
Biological Processes:
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter By Galactose
- Regulation Of Thyroid Hormone Mediated Signaling Pathway
- Transcription, Dna-Templated
- Lactation
- Male Gonad Development
- Bile Acid And Bile Salt Transport
- Cerebellum Development
- Hippocampus Development
- Hypothalamus Development
- Cerebral Cortex Development
- Androgen Receptor Signaling Pathway
- Intracellular Receptor Signaling Pathway
- Response To Estradiol
- Response To Retinoic Acid
- Response To Progesterone
- Cellular Response To Hormone Stimulus
- Positive Regulation Of Apoptotic Process
- Histone H4 Acetylation
- Cellular Lipid Metabolic Process
- Estrous Cycle
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Female Receptivity
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Male Mating Behavior
- Labyrinthine Layer Morphogenesis
- Cellular Response To Thyroglobulin Triiodothyronine