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  3. NCOA1

NCOA1 (Nuclear receptor coactivator 1)

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The Function of NCOA1

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

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Protein names

Recommended name:

Nuclear receptor coactivator 1

Short name:

SRC-1

Alternative name(s):

NCoA-1
Class E basic helix-loop-helix protein 74
bHLHe74
Protein Hin-2
RIP160
Renal carcinoma antigen NY-REN-52
Steroid receptor coactivator 1

NCOA1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2165738 (NCOA1) ??
  2. RS79480871 (NCOA1) ??

Top Gene-Substance Interactions

NCOA1 Interacts with These Diseases

Disease Score

Substances That Increase NCOA1

Substances Interaction Organism Category

Substances That Decrease NCOA1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • STAT5A
  • STAT5B
  • p300

Tissue specificity:

Widely expressed.

Gene Pathways:

  • Metabolism
  • Mus musculus biological processes

Molecular Function:

  • Androgen Receptor Binding
  • Chromatin Binding
  • Enzyme Binding
  • Histone Acetyltransferase Activity
  • Ligand-Dependent Nuclear Receptor Binding
  • Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
  • Nuclear Hormone Receptor Binding
  • Protein N-Terminus Binding
  • Rna Polymerase Ii Regulatory Region Dna Binding
  • Rna Polymerase Ii Transcription Coactivator Activity
  • Transcription Coactivator Activity

Biological Processes:

  • Androgen Receptor Signaling Pathway
  • Bile Acid And Bile Salt Transport
  • Cellular Lipid Metabolic Process
  • Cellular Response To Hormone Stimulus
  • Cellular Response To Thyroglobulin Triiodothyronine
  • Cerebellum Development
  • Cerebral Cortex Development
  • Estrous Cycle
  • Hippocampus Development
  • Histone H4 Acetylation
  • Hypothalamus Development
  • Intracellular Receptor Signaling Pathway
  • Labyrinthine Layer Morphogenesis
  • Lactation
  • Male Gonad Development
  • Male Mating Behavior
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Female Receptivity
  • Positive Regulation Of Neuron Differentiation
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter By Galactose
  • Regulation Of Thyroid Hormone Mediated Signaling Pathway
  • Response To Estradiol
  • Response To Progesterone
  • Response To Retinoic Acid
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_10324| AS27_11768| bHLHe42| bhlhe74| CB1_001328001| class E basic helix-loop-helix protein 74| DKEY-34F16.7| F-SRC-1| GW7_13989| H920_15284| Hin-2 protein| kat13a| M959_00781| MDA_GLEAN10025584| mNRC-1| N301_10063| N303_10168| N320_11824| N327_13919| N333_09803| NCoA-1| NCOA3| NRC-1| nuclear receptor coactivator 1 isoform 2 isoform 3-like protein| nuclear receptor coactivator 1-like protein| nuclear receptor coactivator 3| nuclear receptor coactivator protein 1| PAL_GLEAN10020210| PANDA_001701| PAX3/NCOA1 fusion protein| renal carcinoma antigen NY-REN-52| RIP160| src-1| SRC1| SRC-a| steroid receptor coactivator 1| steroid receptor coactivator-1| TREES_T100020428| UY3_13810| Xsrc1| Y1Q_000613| Y956_03794| ncoa1

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