The Function of NCL
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
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Protein names
Recommended name:
NucleolinAlternative name(s):
Protein C23- RS16828074 (NCL) ??
- RS7598759 (NCL) ??
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Top Gene-Substance Interactions
NCL Interacts with These Diseases
| Disease | Score |
Substances That Increase NCL
| Substances | Interaction | Organism | Category |
Substances That Decrease NCL
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Nucleotide Binding
- Single-Stranded Dna Binding
- Rna Binding
- Calcium Ion Binding
- Protein C-Terminus Binding
- Selenocysteine Insertion Sequence Binding
- Rrna Primary Transcript Binding
- Telomeric Dna Binding
- Identical Protein Binding
- Poly(A) Rna Binding
Biological Processes:
- Angiogenesis
- Endocytosis
- Spermatogenesis
- Positive Regulation Of Tumor Necrosis Factor Production
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cellular Response To Lipopolysaccharide
- Liver Regeneration
- Positive Regulation Of Transcription Of Nuclear Large Rrna Transcript From Rna Polymerase I Promoter
- Regulation Of Rrna Processing
- Positive Regulation Of Interleukin-6 Secretion