• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. NCL

NCL (Nucleolin)

Loading...

The Function of NCL

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Nucleolin

Alternative name(s):

Protein C23

NCL SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS16828074 (NCL) ??
  2. RS7598759 (NCL) ??

Top Gene-Substance Interactions

NCL Interacts with These Diseases

Disease Score

Substances That Increase NCL

Substances Interaction Organism Category

Substances That Decrease NCL

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1
  • Sp1
  • TBP
  • AML1a
  • TFIID

Gene Pathways:

  • Pathogenic Escherichia coli infection

Molecular Function:

  • Identical Protein Binding
  • Nucleotide Binding
  • Poly(A) Rna Binding
  • Protein C-Terminus Binding
  • Rna Binding
  • Telomeric Dna Binding
  • Calcium Ion Binding
  • Rrna Primary Transcript Binding
  • Selenocysteine Insertion Sequence Binding
  • Single-Stranded Dna Binding

Biological Processes:

  • Angiogenesis
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription Of Nuclear Large Rrna Transcript From Rna Polymerase I Promoter
  • Cellular Response To Lipopolysaccharide
  • Endocytosis
  • Liver Regeneration
  • Negative Regulation Of Apoptotic Process
  • Positive Regulation Of Interleukin-6 Secretion
  • Positive Regulation Of Tumor Necrosis Factor Production
  • Regulation Of Rrna Processing
  • Spermatogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13293| AS27_10208| AS28_05973| C23| CB1_000661031| D0Nds28| D1Nds28| fa12d03| H920_08497| I79_022400| M91_11009| M959_04622| MDA_GLEAN10026059| N300_13360| N301_05143| N302_03781| N305_01881| N308_13880| N309_09394| N310_05912| N311_09595| N312_10043| N320_09309| N321_06500| N322_10797| N325_12690| N326_00443| N327_00472| N328_09072| N330_08972| N331_00362| N332_00878| N333_05057| N334_10462| N335_11563| N336_07722| N339_08082| N340_11576| N341_02318| Nucl| nucleolin-like protein| PAL_GLEAN10014303| PANDA_005719| protein C23| QtsA-10605| TREES_T100019082| UY3_05141| Y1Q_001661| Y956_07157| Z169_03234| ncl

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved