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NCAN (Neurocan)

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Summary of NCAN

The gene codes for a protein, neurocan.  It is involved in cell adhesion and migration [R].

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The Function of NCAN

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Protein names

Recommended name:

Neurocan core protein

Alternative name(s):

Chondroitin sulfate proteoglycan 3

NCAN SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1064395 (NCAN) ??
  2. RS2228603 (NCAN) ??

Top Gene-Substance Interactions

NCAN Interacts with These Diseases

Disease Score

Substances That Increase NCAN

Substances Interaction Organism Category

Substances That Decrease NCAN

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • MEF-2A
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • RREB-1
  • ATF6

Tissue specificity:

Brain.

Gene Pathways:

  • Metabolism
  • Disease
  • Extracellular matrix organization

Molecular Function:

  • Calcium Ion Binding
  • Carbohydrate Binding
  • Extracellular Matrix Structural Constituent
  • Hyaluronic Acid Binding

Biological Processes:

  • Cell Adhesion
  • Central Nervous System Development
  • Chondroitin Sulfate Biosynthetic Process
  • Chondroitin Sulfate Catabolic Process
  • Dermatan Sulfate Biosynthetic Process
  • Extracellular Matrix Organization
  • Glycosaminoglycan Metabolic Process
  • Skeletal System Development

Drug Bank:

  • Hyaluronic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ncan| 245 kDa early postnatal core glycoprotein| Anapl_14550| C230035B04| CB1_000878004| chondroitin sulfate proteoglycan 3| chondroitin sulfate proteoglycan 3 (neurocan)| chondroitin sulfate proteoglycan 3, related sequence| Cspg3| Cspg3-rs| D623_10018567| I79_005071| M91_10158| M959_10444| Neurocan core protein| neurocan core protein-like| neurocan proteoglycan| PAL_GLEAN10006722| TGFbeta-induced transcript, brain| Tgfbit| TREES_T100014689| UY3_18741| Y1Q_018016

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