Summary of NCAN
The gene codes for a protein, neurocan. It is involved in cell adhesion and migration [R].
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The Function of NCAN
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Protein names
Recommended name:
Neurocan core proteinAlternative name(s):
Chondroitin sulfate proteoglycan 3- RS1064395 (NCAN) ??
- RS2228603 (NCAN) ??
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Top Gene-Substance Interactions
NCAN Interacts with These Diseases
| Disease | Score |
Substances That Increase NCAN
| Substances | Interaction | Organism | Category |
Substances That Decrease NCAN
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Brain.
Gene Pathways:
Molecular Function:
- Extracellular Matrix Structural Constituent
- Calcium Ion Binding
- Hyaluronic Acid Binding
- Carbohydrate Binding
Biological Processes:
- Skeletal System Development
- Cell Adhesion
- Central Nervous System Development
- Extracellular Matrix Organization
- Glycosaminoglycan Metabolic Process
- Chondroitin Sulfate Biosynthetic Process
- Chondroitin Sulfate Catabolic Process
- Dermatan Sulfate Biosynthetic Process