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NAT8 (N-acetyltransferase 8 (putative))

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Summary of NAT8

The gene codes for a protein, N-acetyltransferase 8 (putative). It is exclusively found in the kidney and liver [R].

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The Function of NAT8

Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).

Protein names

Recommended name:

N-acetyltransferase 8

Short name:

CCNAT

Alternative name(s):

Acetyltransferase 2
ATase2
Camello-like protein 1
Cysteinyl-conjugate N-acetyltransferase

NAT8 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10178409 (NAT8) ??
  2. RS13538 (NAT8) ??

Top Gene-Substance Interactions

Substances That Increase NAT8

Substances Interaction Organism Category

Substances That Decrease NAT8

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Nkx2-5
  • p53

Tissue specificity:

Preferentially expressed in liver and kidney. Also detected in brain (at protein level).

Induction:

Up-regulated by ceramides.

Molecular Function:

  • Lysine N-Acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
  • Cysteine-S-Conjugate N-Acetyltransferase Activity

Biological Processes:

  • Glutathione Metabolic Process
  • Positive Regulation Of Gene Expression
  • Peptidyl-Lysine N6-Acetylation
  • Negative Regulation Of Apoptotic Process
  • Cellular Protein Metabolic Process
  • Beta-Amyloid Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| gla| acetyltransferase 2| ATase2| camello 1| camello-like 4| camello-like protein 1| camello-like protein 4| CCNAT| cml1| Cml4| cysteinyl-conjugate N-acetyltransferase| Hcml1| kidney- and liver-specific gene product| N-acetyltransferase 8| N-acetyltransferase 8B| N-acetyltransferase 8B (putative, gene/pseudogene)| N-acetyltransferase 8 (camello like)| N-acetyltransferase 8 (GCN5-related)| N-acetyltransferase 8 (GCN5-related, putative)| NAT8B| probable N-acetyltransferase 8| probable N-acetyltransferase 8-like| probable N-acetyltransferase camello| probable N-acetyltransferase CML4| putative N-acetyltransferase Camello 4| TSC501| TSC510| nat8

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