Summary of NAT8

The gene codes for a protein, N-acetyltransferase 8 (putative). It is exclusively found in the kidney and liver [R].

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The Function of NAT8

Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).

Protein names

Recommended name:

N-acetyltransferase 8

Short name:

CCNAT

Alternative name(s):

Acetyltransferase 2
ATase2
Camello-like protein 1
Cysteinyl-conjugate N-acetyltransferase

Top Gene-Substance Interactions

Substances That Increase NAT8

Substances That Decrease NAT8

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical