Summary of NAT8
The gene codes for a protein, N-acetyltransferase 8 (putative). It is exclusively found in the kidney and liver [R].
The Function of NAT8
Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).
Protein names
Recommended name:
N-acetyltransferase 8Short name:
CCNATAlternative name(s):
Acetyltransferase 2ATase2
Camello-like protein 1
Cysteinyl-conjugate N-acetyltransferase
- RS10178409 (NAT8) ??
- RS13538 (NAT8) ??
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Top Gene-Substance Interactions
Substances That Increase NAT8
| Substances | Interaction | Organism | Category |
Substances That Decrease NAT8
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Preferentially expressed in liver and kidney. Also detected in brain (at protein level).
Induction:
Up-regulated by ceramides.
Molecular Function:
- Lysine N-Acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
- Cysteine-S-Conjugate N-Acetyltransferase Activity
Biological Processes:
- Glutathione Metabolic Process
- Positive Regulation Of Gene Expression
- Peptidyl-Lysine N6-Acetylation
- Negative Regulation Of Apoptotic Process
- Cellular Protein Metabolic Process
- Beta-Amyloid Metabolic Process