Summary of NAB2
The gene codes for a protein, NGFI-A binding protein 2. It functions to repress transcription induced by some members of the early growth response family [R].
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The Function of NAB2
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
Protein names
Recommended name:
NGFI-A-binding protein 2Alternative name(s):
EGR-1-binding protein 2Melanoma-associated delayed early response protein
Protein MADER
- RS1059513 (NAB2) ??
- RS324017 (NAB2) ??
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Top Gene-Substance Interactions
Substances That Increase NAB2
| Substances | Interaction | Organism | Category |
Substances That Decrease NAB2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed at low levels. Highly expressed in melanoma cell lines.
Induction:
By serum and phorbol myristate acetate (PMA) stimulation.
Molecular Function:
Biological Processes:
- Cell Proliferation
- Endochondral Ossification
- Myelination
- Negative Regulation Of Transcription From Rna Polymerase Iii Promoter
- Nervous System Development
- Regulation Of Epidermis Development
- Schwann Cell Differentiation
- Transcription, Dna-Templated