Summary of NAB2
The gene codes for a protein, NGFI-A binding protein 2. It functions to repress transcription induced by some members of the early growth response family [R].
0 users want this gene increased,
0 users want it decreased
The Function of NAB2
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
Protein names
Recommended name:
NGFI-A-binding protein 2Alternative name(s):
EGR-1-binding protein 2Melanoma-associated delayed early response protein
Protein MADER
- RS1059513 (NAB2) ??
- RS324017 (NAB2) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase NAB2
| Substances | Interaction | Organism | Category |
Substances That Decrease NAB2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed at low levels. Highly expressed in melanoma cell lines.
Induction:
By serum and phorbol myristate acetate (PMA) stimulation.
Molecular Function:
Biological Processes:
- Endochondral Ossification
- Transcription, Dna-Templated
- Nervous System Development
- Cell Proliferation
- Schwann Cell Differentiation
- Negative Regulation Of Transcription From Rna Polymerase Iii Promoter
- Myelination
- Regulation Of Epidermis Development