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  3. NAB2

NAB2 (NGFI-A binding protein 2)

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Summary of NAB2

The gene codes for a protein, NGFI-A binding protein 2. It functions to repress transcription induced by some members of the early growth response family [R].

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The Function of NAB2

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.

Protein names

Recommended name:

NGFI-A-binding protein 2

Alternative name(s):

EGR-1-binding protein 2
Melanoma-associated delayed early response protein
Protein MADER

NAB2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1059513 (NAB2) ??
  2. RS324017 (NAB2) ??

Top Gene-Substance Interactions

Substances That Increase NAB2

Substances Interaction Organism Category

Substances That Decrease NAB2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • Egr-1
  • Egr-2

Tissue specificity:

Widely expressed at low levels. Highly expressed in melanoma cell lines.

Induction:

By serum and phorbol myristate acetate (PMA) stimulation.

Molecular Function:

  • Transcription Corepressor Activity

Biological Processes:

  • Cell Proliferation
  • Endochondral Ossification
  • Myelination
  • Negative Regulation Of Transcription From Rna Polymerase Iii Promoter
  • Nervous System Development
  • Regulation Of Epidermis Development
  • Schwann Cell Differentiation
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_15446| anon-EST:Liang-1.43| BcDNA:LD27873| BEST:GH27517| CG5720 gene product from transcript CG5720-RA| CG5720-PA| clone 1.43| D623_10018365| Dmel_CG5720| dNab2| EGR-1-binding protein 2| EGR1 binding protein 2| H920_14033| M91_11223| MADER| MDA_GLEAN10006668| melanoma-associated delayed early response protein| Nab2-PA| NGFI-A-binding protein 2| NGFI-A binding protein 2 (EGR-1 binding protein 2)| NGFI-A binding protein 2 (EGR1 binding protein 2)| PAL_GLEAN10004848| PANDA_004110| RE28534| TREES_T100018336| Y956_13684| nab2

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