The Function of MYL2
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly.
Protein names
Recommended name:
Myosin regulatory light chain 2, ventricular/cardiac muscle isoformShort name:
MLC-2Alternative name(s):
MLC-2vCardiac myosin light chain 2
Myosin light chain 2, slow skeletal/ventricular muscle isoform
MLC-2s/v
Ventricular myosin light chain 2
- RS3782889 (MYL2) ??
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Top Gene-Substance Interactions
MYL2 Interacts with These Diseases
| Disease | Score |
Substances That Increase MYL2
| Substances | Interaction | Organism | Category |
Substances That Decrease MYL2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Actin Monomer Binding
- Calcium Ion Binding
- Structural Constituent Of Muscle
- Myosin Heavy Chain Binding
Biological Processes:
- Regulation Of The Force Of Heart Contraction
- Regulation Of Striated Muscle Contraction
- Heart Development
- Post-Embryonic Development
- Muscle Filament Sliding
- Negative Regulation Of Cell Growth
- Muscle Cell Fate Specification
- Muscle Fiber Development
- Cardiac Myofibril Assembly
- Ventricular Cardiac Muscle Tissue Morphogenesis
- Heart Contraction
- Cardiac Muscle Contraction
- Positive Regulation Of The Force Of Heart Contraction