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  3. MYL2

MYL2 (Myosin light chain 2)

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The Function of MYL2

Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly.

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Protein names

Recommended name:

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Short name:

MLC-2

Alternative name(s):

MLC-2v
Cardiac myosin light chain 2
Myosin light chain 2, slow skeletal/ventricular muscle isoform
MLC-2s/v
Ventricular myosin light chain 2

MYL2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3782889 (MYL2) ??

Top Gene-Substance Interactions

MYL2 Interacts with These Diseases

Disease Score

Substances That Increase MYL2

Substances Interaction Organism Category

Substances That Decrease MYL2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun

Gene Pathways:

  • Regulation of actin cytoskeleton
  • Leukocyte transendothelial migration
  • Tight junction
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy (HCM)
  • Cardiac muscle contraction
  • Muscle contraction

Molecular Function:

  • Actin Monomer Binding
  • Calcium Ion Binding
  • Myosin Heavy Chain Binding
  • Structural Constituent Of Muscle

Biological Processes:

  • Cardiac Muscle Contraction
  • Cardiac Myofibril Assembly
  • Heart Contraction
  • Heart Development
  • Muscle Cell Fate Specification
  • Muscle Fiber Development
  • Muscle Filament Sliding
  • Negative Regulation Of Cell Growth
  • Positive Regulation Of The Force Of Heart Contraction
  • Post-Embryonic Development
  • Regulation Of Striated Muscle Contraction
  • Regulation Of The Force Of Heart Contraction
  • Ventricular Cardiac Muscle Tissue Morphogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| G2| cardiac muscle isoform| MLC-2A| AS27_00806| AS28_14943| cardiac myosin light chain 2| cardiac myosin light chain-2| cardiac ventricular myosin light chain 2| CB1_000340038| CMH10| D623_10011528| EGK_04188| GW7_10130| H920_15139| I79_004267| light polypeptide 2| M91_16441| M959_11973| MDA_GLEAN10020230| Mlc-2| MLC2| MLC-2s/v| MLC-2v| MLC2V| Mylpc| myosin, light chain 2, regulatory, cardiac, slow| myosin light chain 2, slow skeletal/ventricular muscle isoform| myosin light chain 2v| myosin light chain, phosphorylatable, cardiac ventricles| myosin, light polypeptide 2, regulatory, cardiac, slow| Myosin regulatory light chain 2A, cardiac muscle isoform| myosin regulatory light chain 2, ventricular/cardiac muscle isoform| N300_10291| N301_08451| N302_01356| N303_14413| N305_13750| N306_14646| N307_00919| N308_04138| N309_13991| N310_09659| N312_05843| N321_03909| N327_09668| N330_03890| N333_04563| N341_04643| PAL_GLEAN10008865| PANDA_000880| regulatory light chain of myosin| RLC of myosin| slow cardiac myosin regulatory light chain 2| TREES_T100008957| ventricular myosin light chain 2| ventricular myosin regulatory light chain| XMLC2| Y1Q_006231| Y956_05874| Z169_08406| myl2

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