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  3. MX1

MX1 (MX dynamin like GTPase 1)

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Summary of MX1

The gene codes for a protein, MX dynamin like GTPase 1. It plays a role in cellular antiviral response [R].

0 users want this gene increased, 0 users want it decreased

The Function of MX1

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

Protein names

Recommended name:

Interferon-induced GTP-binding protein Mx1

Short name:

IFI-78K

Alternative name(s):

Interferon-induced protein p78
Interferon-regulated resistance GTP-binding protein MxA
Myxoma resistance protein 1
Myxovirus resistance protein 1

MX1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17000900 (MX1) ??
  2. RS2071430 (MX1) ??
  3. RS459482 (MX1) ??
  4. RS469390 (MX1) ??
  5. RS7280422 (MX1) ??

Top Gene-Substance Interactions

MX1 Interacts with These Diseases

Disease Score

Substances That Increase MX1

Substances Interaction Organism Category

Substances That Decrease MX1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • STAT5A
  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Immune System
  • Measles

Induction:

By type I and type III interferons. Isoform 2 is induced by HSV-1.

Molecular Function:

  • Gtpase Activity
  • Gtp Binding
  • Microtubule Binding

Biological Processes:

  • Apoptotic Process
  • Defense Response
  • Defense Response To Virus
  • Innate Immune Response
  • Negative Regulation Of Viral Genome Replication
  • Organelle Fission
  • Response To Type I Interferon
  • Response To Virus
  • Signal Transduction
  • Type I Interferon Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GTP-binding protein| CB1_000081001| D623_10016518| dynamin family GTP-binding| GTP-binding protein Mx1| IFI78| IFI-78K| Interferon-induced GTP-binding protein Mx| interferon-induced GTP-binding protein Mx1| interferon-induced GTP-binding protein mx1-like protein| interferon-induced GTP-binding protein Mx2| interferon-induced protein p78| Interferon-inducible Mx1 protein| interferon-inducible Mx protein| interferon-inducible myxovirus resistance-1 protein| interferon-inducible protein p78| interferon-regulated resistance GTP-binding protein MxA| MDA_GLEAN10011723| mx| Mx-1| Mx1-b| Mx1B| Mx1 protein| Mx2| MxA| MX dynamin-like GTPase 1| Mx protein homolog| myxocirus-resistance protein| myxoma resistance protein 1| myxovirus (influenza) resistance 1, (murine homolog)| myxovirus (influenza) resistance 1 polypeptide| Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)| myxovirus (influenza virus) resistance 1| myxovirus influenza virus resistance 1| myxovirus (influenza virus) resistance 1, interferon-inducible protein p78| myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)| myxovirus (influenza virus) resistance 2| myxovirus protein| myxovirus resistance 1| myxovirus-resistance protein| myxovirus resistance protein 1| myxovirus resistence| N320_03951| N321_02741| N322_00463| N324_02528| N325_00952| N330_00799| N340_13878| OGTPBP| oligodendrocyte GTP-binding protein| oligodendrocyte nucleotide-binding protein| ONBP| PAL_GLEAN10008392| PANDA_015501| XELAEV_18011415mg| mx1

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