Summary of MX1

The gene codes for a protein, MX dynamin like GTPase 1. It plays a role in cellular antiviral response [R].

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The Function of MX1

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

Protein names

Recommended name:

Interferon-induced GTP-binding protein Mx1

Short name:

IFI-78K

Alternative name(s):

Interferon-induced protein p78
Interferon-regulated resistance GTP-binding protein MxA
Myxoma resistance protein 1
Myxovirus resistance protein 1

Top Gene-Substance Interactions

MX1 Interacts with These Diseases

Substances That Increase MX1

Substances That Decrease MX1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical