Summary of MX1
The gene codes for a protein, MX dynamin like GTPase 1. It plays a role in cellular antiviral response [R].
The Function of MX1
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
Protein names
Recommended name:
Interferon-induced GTP-binding protein Mx1Short name:
IFI-78KAlternative name(s):
Interferon-induced protein p78Interferon-regulated resistance GTP-binding protein MxA
Myxoma resistance protein 1
Myxovirus resistance protein 1
- RS17000900 (MX1) ??
- RS2071430 (MX1) ??
- RS459482 (MX1) ??
- RS469390 (MX1) ??
- RS7280422 (MX1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
MX1 Interacts with These Diseases
Disease | Score |
Substances That Increase MX1
Substances | Interaction | Organism | Category |
Substances That Decrease MX1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By type I and type III interferons. Isoform 2 is induced by HSV-1.
Molecular Function:
Biological Processes:
- Apoptotic Process
- Defense Response
- Defense Response To Virus
- Innate Immune Response
- Negative Regulation Of Viral Genome Replication
- Organelle Fission
- Response To Type I Interferon
- Response To Virus
- Signal Transduction
- Type I Interferon Signaling Pathway