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  3. MTMR4

MTMR4 (Myotubularin related protein 4)

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Summary of MTMR4

The gene codes for a protein, myotubularin related protein 4. It is on chromosome 17 [R].

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The Function of MTMR4

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).

Protein names

Recommended name:

Myotubularin-related protein 4

Short name:

FYVE-DSP2

Alternative name(s):

FYVE domain-containing dual specificity protein phosphatase 2
Zinc finger FYVE domain-containing protein 11

MTMR4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2302189 (MTMR4) ??
  2. RS2302190 (MTMR4) ??

Top Gene-Substance Interactions

Substances That Increase MTMR4

Substances Interaction Organism Category

Substances That Decrease MTMR4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • c-Fos
  • Fra-1
  • JunD
  • Gfi-1
  • LCR-F1

Tissue specificity:

Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.

Gene Pathways:

  • Metabolism
  • Disease
  • Signal Transduction

Developmental stage:

Expressed in fetal brain and fetal liver.

Molecular Function:

  • Metal Ion Binding
  • Phosphatidylinositol-3,5-Bisphosphate 3-Phosphatase Activity
  • Phosphatidylinositol-3-Phosphatase Activity
  • Protein Serine/Threonine Phosphatase Activity
  • Protein Tyrosine Phosphatase Activity

Biological Processes:

  • Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
  • Phosphatidylinositol Biosynthetic Process
  • Protein Dephosphorylation
  • Response To Denervation Involved In Regulation Of Muscle Adaptation
  • Transforming Growth Factor Beta Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00749| AS27_05263| AS28_07981| D623_10005404| ESTM44| FYVE domain-containing dual specificity protein phosphatase 2| fyve-dsp2| FYVE zinc finger phosphatase| M91_18581| M959_11298| MDA_GLEAN10012140| Myotubularin-related protein 4| N300_07236| N301_13875| N303_12912| N305_12230| N306_01881| N307_08307| N308_15254| N309_04452| N310_03882| N311_03046| N324_10298| N327_07277| N329_01732| N330_07160| N331_02680| N332_02698| N333_11684| N334_13627| N335_08230| N339_05626| N340_05120| PANDA_019620| UY3_19082| Y1Q_024466| Y956_15270| Z169_00529| ZFYVE11| zinc finger, FYVE domain containing 11| zinc finger FYVE domain-containing protein 11| mtmr4

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