Summary of MTMR4
The gene codes for a protein, myotubularin related protein 4. It is on chromosome 17 [R].
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The Function of MTMR4
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
Protein names
Recommended name:
Myotubularin-related protein 4Short name:
FYVE-DSP2Alternative name(s):
FYVE domain-containing dual specificity protein phosphatase 2Zinc finger FYVE domain-containing protein 11
- RS2302189 (MTMR4) ??
- RS2302190 (MTMR4) ??
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Top Gene-Substance Interactions
Substances That Increase MTMR4
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Substances That Decrease MTMR4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.
Gene Pathways:
Developmental stage:
Expressed in fetal brain and fetal liver.
Molecular Function:
- Metal Ion Binding
- Phosphatidylinositol-3,5-Bisphosphate 3-Phosphatase Activity
- Phosphatidylinositol-3-Phosphatase Activity
- Protein Serine/Threonine Phosphatase Activity
- Protein Tyrosine Phosphatase Activity
Biological Processes:
- Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
- Phosphatidylinositol Biosynthetic Process
- Protein Dephosphorylation
- Response To Denervation Involved In Regulation Of Muscle Adaptation
- Transforming Growth Factor Beta Receptor Signaling Pathway