• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. MTDH

MTDH (Metadherin)

Loading...

Summary of MTDH

MTDH (Metadherin) encodes proteins that are involved in the formation of new blood vessels (R). 

The protein helps in progression and development of cancer by promoting angiogenesis (R). 

0 users want this gene increased, 0 users want it decreased

The Function of MTDH

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Protein names

Recommended name:

Protein LYRIC

Short name:

AEG-1

Alternative name(s):

3D3/LYRIC
Astrocyte elevated gene-1 protein
Lysine-rich CEACAM1 co-isolated protein
Metadherin
Metastasis adhesion protein

MTDH SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1835740 (MTDH) ??

Top Gene-Substance Interactions

MTDH Interacts with These Diseases

Disease Score

Substances That Increase MTDH

Substances Interaction Organism Category

Substances That Decrease MTDH

Substances Interaction Organism Category

Advanced Summary

MTDH (Metadherin) encodes proteins that are involved in the formation of new blood vessels (R). 

It helps in progression and development of cancer (R). 

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1
  • c-Myc

Tissue specificity:

Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

Induction:

By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes.

Caution:

Was originally thought to be a type II membrane protein but this is inconsistent with the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen or extracellularly rather than in the cytoplasm.

Molecular Function:

  • Double-Stranded Rna Binding
  • Nf-Kappab Binding
  • Poly(A) Rna Binding
  • Rna Polymerase Ii Transcription Factor Binding
  • Transcription Coactivator Activity

Biological Processes:

  • Bicellular Tight Junction Assembly
  • Lipopolysaccharide-Mediated Signaling Pathway
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Autophagy
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Nf-Kappab Transcription Factor Activity
  • Positive Regulation Of Protein Kinase B Signaling
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 3d3| 3D3/LYRIC| A306_00115| aeg1| aeg-1| AS27_05215| AS28_02675| astrocyte elevated gene 1| astrocyte elevated gene-1 protein| AV353288| D623_10032127| D8Bwg1112e| EH28_21150| H920_03384| I79_011053| Lyric| LYRIC/3D3| LYRIC-like protein| lysine-rich CEACAM1 co-isolated protein| M91_09163| M959_13853| MDA_GLEAN10013286| metastasis adhesion protein| N301_02615| N302_08285| N305_12630| N308_05092| N310_01015| N311_06545| N312_05493| N320_13142| N322_13737| N325_10811| N326_00680| N327_05119| N328_09051| N329_00735| N330_05592| N331_08310| N333_01647| N334_02920| N335_11201| N336_00808| N339_10951| N341_12926| PAL_GLEAN10021488| PANDA_001888| Protein LYRIC| protein LYRIC-like protein| UY3_03415| Y1Q_002733| Y956_13046| Z169_02573| mtdh

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved