Summary of MTDH
The Function of MTDH
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Protein names
Recommended name:
Protein LYRICShort name:
AEG-1Alternative name(s):
3D3/LYRICAstrocyte elevated gene-1 protein
Lysine-rich CEACAM1 co-isolated protein
Metadherin
Metastasis adhesion protein
- RS1835740 (MTDH) ??
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Top Gene-Substance Interactions
MTDH Interacts with These Diseases
| Disease | Score |
Substances That Increase MTDH
| Substances | Interaction | Organism | Category |
Substances That Decrease MTDH
| Substances | Interaction | Organism | Category |
Advanced Summary
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
Induction:
By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes.
Caution:
Was originally thought to be a type II membrane protein but this is inconsistent with the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen or extracellularly rather than in the cytoplasm.
Molecular Function:
- Double-Stranded Rna Binding
- Nf-Kappab Binding
- Poly(A) Rna Binding
- Rna Polymerase Ii Transcription Factor Binding
- Transcription Coactivator Activity
Biological Processes:
- Bicellular Tight Junction Assembly
- Lipopolysaccharide-Mediated Signaling Pathway
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Autophagy
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Positive Regulation Of Protein Kinase B Signaling