The Function of MST1R
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Protein names
Recommended name:
Macrophage-stimulating protein receptorAlternative name(s):
MSP receptorCDw136
Protein-tyrosine kinase 8
p185-Ron
CD antigen CD136
Top Gene-Substance Interactions
MST1R Interacts with These Diseases
| Disease | Score |
Substances That Increase MST1R
| Substances | Interaction | Organism | Category |
Substances That Decrease MST1R
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in colon, skin, lung and bone marrow.
Enzyme Regulation:
In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
Molecular Function:
Biological Processes:
- Defense Response
- Hepatocyte Growth Factor Receptor Signaling Pathway
- Innate Immune Response
- Movement Of Cell Or Subcellular Component
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Map Kinase Activity
- Positive Regulation Of Protein Kinase B Signaling
- Response To Virus
- Signal Transduction
- Single Fertilization