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  3. MSR1

MSR1 (Macrophage scavenger receptor 1)

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Summary of MSR1

The gene codes for a protein, macrophage scavenger receptor 1. It is implicated in atherosclerosis, Alzheimer's disease, and host defense [R].

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The Function of MSR1

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.

Protein names

Recommended name:

Macrophage scavenger receptor types I and II

Alternative name(s):

Macrophage acetylated LDL receptor I and II
Scavenger receptor class A member 1
CD antigen CD204

MSR1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13340561 (MSR1) ??
  2. RS240657 (MSR1) ??
  3. RS3747531 (MSR1) ??
  4. RS41341748 (MSR1) ??
  5. RS7002619 (MSR1) ??

Top Gene-Substance Interactions

MSR1 Interacts with These Diseases

Disease Score

Substances That Increase MSR1

Substances Interaction Organism Category

Substances That Decrease MSR1

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: prostate cancerFrom NCBI Gene: Malignant tumor of prostateBarrett's esophagusFrom UniProt: Barrett esophagus (BE): A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. [MIM:614266] Prostate cancer (PC): A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. [MIM:176807]

     From NCBI Gene: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] From UniProt: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • PPAR-alpha

Tissue specificity:

Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.

Gene Pathways:

  • Phagosome

Molecular Function:

  • Low-Density Lipoprotein Particle Binding
  • Scavenger Receptor Activity

Biological Processes:

  • Cellular Response To Organic Cyclic Compound
  • Cholesterol Transport
  • Lipoprotein Transport
  • Plasma Lipoprotein Particle Clearance
  • Positive Regulation Of Cholesterol Storage
  • Positive Regulation Of Macrophage Derived Foam Cell Differentiation
  • Receptor-Mediated Endocytosis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Macrophage receptor MARCO| anon-WO0170980.106| anon-WO0170980.107| CB1_001559002| CD204| CG8985 gene product from transcript CG8985-RA| CG8985-PA| CG8985-PB| Dm CG8985| Dmel_CG8985| DmsR| DMS-R1| DMSR-1| DMS-receptor1| dromyosuppressin receptor 1| GW7_17769| H920_04258| I79_003188| macrophage acetylated LDL receptor I and II| macrophage scavenger receptor 1 isoform type 2 isoform 3-like protein| macrophage scavenger receptor type I| macrophage scavenger receptor type III| macrophage scavenger receptor types I and II| MDA_GLEAN10019651| MRS-A| MSR| MsR1-PA| MsR1-PB| MSR-A| Myosuppressin receptor 1| N321_03246| PAL_GLEAN10021695| PANDA_018639| phSR1| phSR2| RGD1564316| Scara1| scavenger receptor class A member 1| scavenger receptor type A| Scvr| SRA| SR-A| SR-AI| SR-AII| TREES_T100012626| msr1

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