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  3. MPZL1

MPZL1 (Myelin protein zero like 1)

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The Function of MPZL1

Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

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Protein names

Recommended name:

Myelin protein zero-like protein 1

Alternative name(s):

Protein zero-related

MPZL1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4145462 (MPZL1) ??

Top Gene-Substance Interactions

MPZL1 Interacts with These Diseases

Disease Score

Substances That Increase MPZL1

Substances Interaction Organism Category

Substances That Decrease MPZL1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • GR
  • GR-alpha
  • Nkx2-2
  • Cdc5
  • Nkx3-1
  • LyF-1

Tissue specificity:

Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.

Gene Pathways:

  • Cell adhesion molecules (CAMs)

Molecular Function:

  • Structural Molecule Activity

Biological Processes:

  • Cell-Cell Signaling
  • Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07215| AS27_08062| AS28_01806| CB1_002523014| D623_10024374| H920_09485| I79_008839| immunoglobulin family transmembrane protein| M91_01086| M959_09022| MDA_GLEAN10013488| mpzl1b| myelin protein zero-like 1| Myelin protein zero-like protein 1| N300_10731| N301_07191| N302_03485| N303_03287| N305_13311| N306_01545| N307_02180| N308_00592| N310_07042| N312_01501| N320_03874| N322_11725| N324_07669| N325_11485| N326_11842| N327_04435| N329_12215| N330_02579| N332_01610| N333_03987| N334_00878| N335_01728| N336_07396| N341_09837| PAL_GLEAN10017852| PANDA_018065| protein zero related| protein zero-related| putative myelin protein zero-like 1 variant 1| PZR| pzr1b| pzra| pzrb| UY3_04946| Y1Q_007898| Y956_12377| Z169_12195| zero-related protein| mpzl1

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