The Function of MOCS2
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
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Protein names
Recommended name:
Molybdopterin synthase catalytic subunitShort name:
MOCS2BAlternative name(s):
MOCO1-BMolybdenum cofactor synthesis protein 2 large subunit
Molybdenum cofactor synthesis protein 2B
Molybdopterin-synthase large subunit
MPT synthase large subunit
Top Gene-Substance Interactions
Substances That Increase MOCS2
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Substances That Decrease MOCS2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes.