Summary of MMP9
MMP9 codes for proteins of the matrix metalloproteinase (MMP) family. They are involved in the breakdown of extracellular matrix in processes like embryonic development, reproduction, and tissue remodeling, as well as in diseases like arthritis and metastasis (R).
Skeletal and muscle disorders are associated with this gene (R).
The Function of MMP9
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Protein names
Recommended name:
Matrix metalloproteinase-9Short name:
GELBAlternative name(s):
MMP-992 kDa gelatinase
92 kDa type IV collagenase
Gelatinase B
- RS3787268 (MMP9) ??
- RS3918241 (MMP9) ??
- RS3918242 (MMP9) ??
- RS41529445 (MMP9) ??
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Top Gene-Substance Interactions
MMP9 Interacts with These Diseases
| Disease | Score |
Substances That Increase MMP9
| Substances | Interaction | Organism | Category |
Substances That Decrease MMP9
| Substances | Interaction | Organism | Category |
Advanced Summary
MMP9 codes for proteins of the matrix metalloproteinase (MMP) family. They are involved in the breakdown of extracellular matrix in processes like embryonic development, reproduction, and tissue remodeling, as well as in diseases like arthritis and metastasis (R).
Skeletal and muscle disorders are associated with this gene (R).
The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and mouse studies suggest a role in tumor-associated tissue remodeling.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Produced by normal alveolar macrophages and granulocytes.
Gene Pathways:
Induction:
(Microbial infection) Expression induced by M.bovis MPB83 (at protein level) (PubMed:20800577).
Enzyme Regulation:
Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.
Cofactor:
Binds 3 Ca(2+) ions per subunit.
Molecular Function:
- Collagen Binding
- Endopeptidase Activity
- Metalloendopeptidase Activity
- Metallopeptidase Activity
- Serine-Type Endopeptidase Activity
- Zinc Ion Binding
- Identical Protein Binding
Biological Processes:
- Collagen Catabolic Process
- Embryo Implantation
- Endodermal Cell Differentiation
- Ephrin Receptor Signaling Pathway
- Extracellular Matrix Disassembly
- Leukocyte Migration
- Macrophage Differentiation
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Cation Channel Activity
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
- Ossification
- Positive Regulation Of Dna Binding
- Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Keratinocyte Migration
- Positive Regulation Of Protein Phosphorylation
- Positive Regulation Of Receptor Binding
- Positive Regulation Of Release Of Cytochrome C From Mitochondria
- Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
- Proteolysis
- Skeletal System Development
Drug Bank:
- Captopril
- Marimastat
- Minocycline
- Glucosamine