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  3. MMP9

MMP9 (Matrix metallopeptidase 9)

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Summary of MMP9

MMP9 codes for proteins of the matrix metalloproteinase (MMP) family. They are involved in the breakdown of extracellular matrix in processes like embryonic development, reproduction, and tissue remodeling, as well as in diseases like arthritis and metastasis (R). 

Skeletal and muscle disorders are associated with this gene (R). 

It's better to have this gene decreased most of the time.
0 users want this gene increased, 0 users want it decreased

The Function of MMP9

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Protein names

Recommended name:

Matrix metalloproteinase-9

Short name:

GELB

Alternative name(s):

MMP-9
92 kDa gelatinase
92 kDa type IV collagenase
Gelatinase B

MMP9 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3787268 (MMP9) ??
  2. RS3918241 (MMP9) ??
  3. RS3918242 (MMP9) ??
  4. RS41529445 (MMP9) ??

Top Gene-Substance Interactions

MMP9 Interacts with These Diseases

Disease Score

Substances That Increase MMP9

Substances Interaction Organism Category

Substances That Decrease MMP9

Substances Interaction Organism Category

Advanced Summary

MMP9 codes for proteins of the matrix metalloproteinase (MMP) family. They are involved in the breakdown of extracellular matrix in processes like embryonic development, reproduction, and tissue remodeling, as well as in diseases like arthritis and metastasis (R). 

Skeletal and muscle disorders are associated with this gene (R). 

The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and mouse studies suggest a role in tumor-associated tissue remodeling.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • GR
  • AP-1
  • c-Jun
  • NF-kappaB1
  • Fra-1
  • NF-AT2

Tissue specificity:

Produced by normal alveolar macrophages and granulocytes.

Gene Pathways:

  • Pathways in cancer
  • Leukocyte transendothelial migration
  • Bladder cancer
  • Signal Transduction
  • Extracellular matrix organization
  • GnRH signaling pathway

Induction:

(Microbial infection) Expression induced by M.bovis MPB83 (at protein level) (PubMed:20800577).

Enzyme Regulation:

Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.

Cofactor:

Binds 3 Ca(2+) ions per subunit.

Molecular Function:

  • Collagen Binding
  • Endopeptidase Activity
  • Metalloendopeptidase Activity
  • Metallopeptidase Activity
  • Serine-Type Endopeptidase Activity
  • Zinc Ion Binding
  • Identical Protein Binding

Biological Processes:

  • Collagen Catabolic Process
  • Embryo Implantation
  • Endodermal Cell Differentiation
  • Ephrin Receptor Signaling Pathway
  • Extracellular Matrix Disassembly
  • Leukocyte Migration
  • Macrophage Differentiation
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cation Channel Activity
  • Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
  • Ossification
  • Positive Regulation Of Dna Binding
  • Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
  • Positive Regulation Of Keratinocyte Migration
  • Positive Regulation Of Protein Phosphorylation
  • Positive Regulation Of Receptor Binding
  • Positive Regulation Of Release Of Cytochrome C From Mitochondria
  • Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
  • Proteolysis
  • Skeletal System Development

Drug Bank:

  • Captopril
  • Marimastat
  • Minocycline
  • Glucosamine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)| matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)| 75 kDa gelatinase| 92 kDa gelatinase| 92 kDa type IV collagenase| 92-kDa type IV collagenase| 92kD gelatinase| 92kD type IV collagenase| AS27_11035| B/MMP9| CB1_001010015| Clg4b| collagenase type IVB| EGK_02336| EH28_18140| fgMMP-9| fj05a08| gelatinase B| gelb| gel-b| Gel B| GW7_06547| H920_06188| M959_11051| macrophage gelatinase| mandp2| matrix metalloproteinase 9| matrix metalloproteinase-9| matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)| matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)| matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)| matrix metalloproteinase-9 preproprotein| MMP2| MMP-9| N300_15602| N301_06128| N303_11913| N305_03132| N307_02892| N335_05470| PAL_GLEAN10024417| PANDA_018019| Preproform of 92-kDa type IV collagenase (MMP-9): N-terminal| pro-MMP-9| TREES_T100021004| type IV collagenase MMP-9| type V collagenase| UY3_14616| Z169_08671| ZFMMP-9| mmp9

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