Summary of MMP7
This gene encodes a protein that helps the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. It also breaks down the extracellular matrix during arthritis and metastasis (R).
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The Function of MMP7
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Protein names
Recommended name:
MatrilysinShort name:
MMP-7Alternative name(s):
MatrinMatrix metalloproteinase-7
Pump-1 protease
Uterine metalloproteinase
- RS10502001 (MMP7) ??
- RS11568818 (MMP7) ??
- RS11568819 (MMP7) ??
- RS12184413 (MMP7) ??
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Top Gene-Substance Interactions
MMP7 Interacts with These Diseases
| Disease | Score |
Substances That Increase MMP7
| Substances | Interaction | Organism | Category |
Substances That Decrease MMP7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 2 Zn(2+) ions per subunit.
Molecular Function:
Biological Processes:
- Proteolysis
- Aging
- Extracellular Matrix Disassembly
- Collagen Catabolic Process
- Response To Nutrient Levels
- Estrous Cycle
- Maternal Process Involved In Female Pregnancy
- Cellular Response To Mechanical Stimulus