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  3. MMP7

MMP7 (Matrix metallopeptidase 7)

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Summary of MMP7

This gene encodes a protein that helps the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. It also breaks down the extracellular matrix during arthritis and metastasis (R). 

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The Function of MMP7

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Protein names

Recommended name:

Matrilysin

Short name:

MMP-7

Alternative name(s):

Matrin
Matrix metalloproteinase-7
Pump-1 protease
Uterine metalloproteinase

MMP7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10502001 (MMP7) ??
  2. RS11568818 (MMP7) ??
  3. RS11568819 (MMP7) ??
  4. RS12184413 (MMP7) ??

Top Gene-Substance Interactions

MMP7 Interacts with These Diseases

Disease Score

Substances That Increase MMP7

Substances Interaction Organism Category

Substances That Decrease MMP7

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • STAT3
  • HNF-4alpha1
  • HNF-4alpha2
  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Wnt signaling pathway
  • Extracellular matrix organization

Cofactor:

Binds 2 Zn(2+) ions per subunit.

Molecular Function:

  • Heparin Binding
  • Metalloendopeptidase Activity
  • Serine-Type Endopeptidase Activity
  • Zinc Ion Binding

Biological Processes:

  • Aging
  • Cellular Response To Mechanical Stimulus
  • Collagen Catabolic Process
  • Estrous Cycle
  • Extracellular Matrix Disassembly
  • Maternal Process Involved In Female Pregnancy
  • Proteolysis
  • Response To Nutrient Levels

Drug Bank:

  • Marimastat
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| MAT| Stromelysin-2| matrix metalloproteinase 7| mmp7| Anapl_05634| AS27_09559| AS28_09250| CB1_000877035| Collagenase 3| D623_10023418| EGK_05766| H920_12970| M959_14459| matrilysin| Matrilysin precursor-like protein| matrilysin-related protein| matrilysin, uterine| matrin| matrix metallopeptidase 7 (matrilysin, uterine)| Matrix metalloproteinase-18| matrix metalloproteinase-7| Matrix metalloproteinase 7 (matrilysin)| matrix metalloproteinase 7 (matrilysin, uterine)| MMP-7| MPMM| MPSL1| N300_01678| N301_15927| N302_15446| N303_08979| N305_11810| N306_00393| N307_00380| N308_05236| N309_07530| N310_11656| N311_11874| N312_11582| N320_12290| N321_11817| N322_11620| N324_05062| N325_00850| N326_08403| N327_12536| N328_12729| N329_02169| N330_01373| N331_01724| N333_04202| N334_13614| N335_13168| N336_01432| N341_12971| PAL_GLEAN10013818| PANDA_010999| pump-1| pump-1 protease| Stromelysin-1| TREES_T100006579| uterine matrilysin| uterine metalloproteinase| Y1Q_008886| Y956_13572| Z169_12515

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